[Solomonov Seminar] 233. Solomonov seminar

[Marko Grobelnik]

V torek, 30.6. bo ob 13:00 v v Oranzni predavalnici IJS
(drugo nadstropje glavne stavbe IJS) 233. Solomonov seminar.
Posnetki preteklih seminarjev so na http://videolectures.net/solomon/

Tokrat bo predaval Barry Hardy iz podjetja Douglas Connect iz Svice
o semantichnih tehnologijah za toksikologijo.

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Barry Hardy, OpenTox Project Coordinator, Douglas Connect, Switzerland

Title: OpenTox - the creation of a Semantic Web for Toxicology

Abstract:
A new paradigm of 21st century human-oriented safety testing approaches 
is now emerging based on a combination of in silico and in vitro 
approaches. The new predictive test systems developed from this growing 
“grand challenge” effort will need to combine evidences from a great 
variety of data, protocols, and concepts. The combination of these 
sources of knowledge within an ontology-based mechanistic 
knowledge-oriented framework to produce reliable test systems demands 
the development of a semantic web for toxicology. The OpenTox Framework 
(1,2) has been developed to support the communication between toxicology 
resources, based on standard representations of data and metadata, the 
ability for distributed resources to exchange data and metadata, build 
and validate models, and generate reporting information relevant for 
research analysis or risk assessment. I will describe the design and 
semantic architecture of OpenTox and example applications it can 
currently enable including a) creation and validation of models 
addressing the regulatory requirements of the REACH legislation for 
chemical safety evaluation (3), b) application in drug discovery 
infrastructure development and weight-of-evidence library profiling of 
drug candidate molecules (4), c) infrastructure development for the 
interdisciplinary research activities of a large cluster of over 70 
partners collaborating on the replacement of animal testing in the area 
of systemic toxicology (5,6), and d) relevance for ecosystem protection 
and biodiversity preservation, including sustainable development 
contexts in both Europe and Africa (7).

(1) OpenTox - An Open Source Predictive Toxicology Framework, is funded 
under the EU Seventh Framework Program: HEALTH-2007-1.3-3 Promotion, 
development, validation, acceptance and implementation of QSARs 
(Quantitative Structure-Activity Relationships) for toxicology, Project 
Reference Number Health-F5-2008-200787 (2008-2011). More information at 
www.opentox.org
(2) Collaborative Development of Predictive Toxicology Applications
Barry Hardy, Nicki Douglas, Christoph Helma, Micha Rautenberg, Nina 
Jeliazkova, Vedrin Jeliazkov, Ivelina Nikolova, Romualdo Benigni, Olga 
Tcheremenskaia, Stefan Kramer, Tobias Girschick, Fabian Buchwald, Joerg 
Wicker, Andreas Karwath, Martin Gutlein, Andreas Maunz, Haralambos 
Sarimveis, Georgia Melagraki, Antreas Afantitis, Pantelis Sopasakis, 
David Gallagher, Vladimir Poroikov, Dmitry Filimonov, Alexey Zakharov, 
Alexey Lagunin, Tatyana Gloriozova, Sergey Novikov, Natalia Skvortsova, 
Dmitry Druzhilovsky, Sunil Chawla, Indira Ghosh, Surajit Ray, Hitesh 
Patel and Sylvia Escher
Journal of Cheminformatics 2010, 2:7 (31 August 2010)
Full text and supplementary information available in Open Access at:
www.jcheminf.com/content/2/1/7
(3) REACH, http://ec.europa.eu/environment/chemicals/reach/reach_intro.htm
(4) Scientists Against Malaria, http://scientistsagainstmalaria.net/
(5) SEURAT-1, http://www.seurat-1.eu/
(6) ToxBank, http://www.toxbank.net/
(7) SETAC Africa Conference, 2011, http://cameroon.setac.eu/