Vabilo na Preglov kolokvij 5.1.2012

[Brigita Pirc]

VABILO NA PREGLOV KOLOKVIJ /  INVITATION TO THE PREGL COLLOQUIUM

 

 

Prof. Dr. Jure Piškur

 

Lund University, Cell and Organism Biology, Sölvegatan 35,  SE-22362 Lund, Sweden

 

Parallel evolution of the make–accumulate–consume strategy in Saccharomyces and Dekkera yeasts

/

Vzporedna evolucija pri kvasovkah 

 

 

Četrtek / Thursday, 5. 1. 2012, ob / at 13:00


Velika predavalnica Kemijskega inštituta / Lecture Hall at the National Institute of Chemistry; Hajdrihova 19, Ljubljana 


 

Elżbieta Rozpędowska,1 Linda Hellborg,1 Olena P. Ishchuk,1 Furkan Orhan,1 Silvia Galafassi,2 Annamaria Merico,2 Megan Woolfit,3,4 Concetta Compagno,2 and Jure Piškura1

 

1Department of Biology, Lund University, Sölvegatan 35, 223 62 Lund, Sweden.

2Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano, via Celoria 26, 20133 Milan, Italy.

3Department of Genetics, Smurfit Institute, Trinity College Dublin, Dublin 2, Ireland.

4School of Biological Sciences, University of Queensland, Brisbane, Queensland 4072, Australia.

 

Abstract:

Saccharomyces yeasts degrade sugars to two-carbon components, in particular ethanol, even in the presence of excess oxygen. This characteristic is called the Crabtree effect and is the background for the 'make–accumulate–consume' life strategy, which in natural habitats helps Saccharomyces yeasts to out-compete other microorganisms. A global promoter rewiring in the Saccharomyces cerevisiae lineage, which occurred around 100 mya, was one of the main molecular events providing the background for evolution of this strategy. Here we show that the Dekkera bruxellensis lineage, which separated from the Saccharomyces yeasts more than 200 mya, also efficiently makes, accumulates and consumes ethanol and acetic acid. Analysis of promoter sequences indicates that both lineages independently underwent a massive loss of a specific cis-regulatory element from dozens of genes associated with respiration, and we show that also in D. bruxellensis this promoter rewiring contributes to the observed Crabtree effect.


Predavanje bo v slovenščini / The Lecture will be given in Slovenian language.

 

Vljudno vabljeni! / Kindly invited!

 

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