Danes: IJS KOLOKVIJ, sreda, 9. 4. 2025, ob 13. uri, prof. dr. Jernej Ule

[Natasa Goševac]

Vabimo vas na 8. predavanje iz sklopa »Kolokviji na IJS« v akademskem letu 2024/25, ki bo danes, 9. aprila 2025, ob 13:00 v Veliki predavalnici Instituta »Jožef Stefan« na Jamovi cesti 39 v Ljubljani. Predavanje bo v angleščini. Na voljo bodo kava, pijača in prigrizki.

 

 

Kako povratne zanke med proteini in mRNA ohranjajo celično ravnovesje

 

prof. dr. Jernej Ule

Inštitut Francisa Cricka in King's College London, London, Velika Britanija, ter

Kemijski inštitut, Ljubljana, Slovenija

 

 

Mnogi proteini se lahko povežejo z RNA in na ta način tvorijo granule v celicah, katerih spremembe so značilni pojav v številnih nevrodegenerativnih boleznih. Opisal bom naše nedavne raziskave, ki kažejo, da nekateri proteini lahko v granule privlačijo svoje lastne mRNA, kadar se le-te nakopičijo v preveliki količini. Ta pojav ustvari povratno zanko, ki uravnava raven teh proteinov v celici. Zanimivo je, da je to uravnavanje skupinsko, in zato proučujemo, kako vpliva na ravnovesje celic. Ugotovili smo tudi, da so določeni deli mRNA oblikovani tako, da olajšajo tvorbo teh granul, kar je razvidno predvsem v genomskih sekvencah kopenskih vretenčarjev. Trenutno raziskujemo, kako ta pojav morda varuje pred staranjem in razvojem nevrodegenerativnih bolezni.

 

O predavatelju: Jernej Ule je vodja Britanskega raziskovalnega centra za raziskavo demence na King's College London, kjer je tudi profesor, hkrati pa je častni profesor na University College London. Redno gosti poletne študente v okviru programa ASEF in sodeluje tudi z raziskovalci na Kemijskem inštitutu v Ljubljani.

 

 

Napovednik predavanja in posnetke preteklih predavanj najdete na novi spletni strani »Kolokvijev na IJS«  <https://kolokviji.ijs.si/> https://kolokviji.ijs.si/, posnetke pa tudi posebej na  <https://video.arnes.si/?q=Kolokviji_IJS> https://video.arnes.si/?q=Kolokviji_IJS (zadnje tri sezone) in  <http://videolectures.net/kolokviji_ijs> http://videolectures.net/kolokviji_ijs (starejši).

 

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We invite you to the 8th lecture in the framework of »JSI Colloquia« in the academic year 2024/25, which will take place today, April 9, 2025, at 1:00 PM in the main lecture hall of Jožef Stefan Institute, Jamova cesta 39 in Ljubljana. The lecture will be held in English. Coffee, drinks and snacks will be available.

 

 

How feedback loops between proteins and mRNA maintain cellular homeostasis

 

Prof. Dr. Jernej Ule

The Francis Crick Institute and King’s College London, London, United Kingdom, and

National Institute of Chemistry, Ljubljana, Slovenia

 

 

Many proteins can bind to RNA and in this way form granules in cells, whose changes are a characteristic phenomenon in many neurodegenerative diseases. I will describe our recent research showing that some proteins can attract their own mRNAs into granules when they accumulate in excessive amounts. This phenomenon creates a feedback loop that regulates the level of these proteins in the cell. Interestingly, this regulation is collective, so we are looking at how it affects cellular homeostasis. We also found that certain parts of the mRNA are designed to facilitate the formation of these granules, which is most apparent in the genomic sequences of terrestrial vertebrates. We are currently investigating how this phenomenon may protect against ageing and the development of neurodegenerative diseases.

 

About the lecturer: Jernej Ule is director of the UK Dementia Research Centre at King's College London, where he is also a professor, and honorary professor at University College London. He regularly hosts summer students under the ASEF programme and also collaborates with researchers at the National Institute of Chemistry in Ljubljana.

 

 

The lecture trailer and recordings of past lectures can be found on the new website of »JSI colloquia«  <https://kolokviji.ijs.si/> https://kolokviji.ijs.si/, and recordings specifically at  <https://video.arnes.si/en/?q=Kolokviji_IJS> https://video.arnes.si/en/?q=Kolokviji_IJS (last three seasons) and  <http://videolectures.net/kolokviji_ijs> http://videolectures.net/kolokviji_ijs (older).

 

 

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