IJS KOLOKVIJ, Sreda, 24. 08. 2016; ob 13. uri; prof. dr. Christian Eggeling

[Tanja Debevec]

Vabimo vas na 22. predavanje iz sklopa "Kolokviji na IJS" v letu 2015/16, ki bo v sredo, 24. avgusta 2016, ob 13. uri v Veliki predavalnici Instituta »Jožef Stefan«  na Jamovi cesti 39 v Ljubljani. Napovednik predavanja najdete tudi na naslovu http://www.ijs.si/ijsw/Koledar_prireditev, posnetke preteklih predavanj pa na http://videolectures.net/kolokviji_ijs. 

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prof. dr. Christian Eggeling

Univerza v Oxfordu, Oxford, Velika Britanija

 

Optična mikroskopija izjemne ločljivosti: nova dognanja in preostale naloge

 

Učinkovito delovanje človeškega telesa vključuje sintezo več ravni od kolektivnega delovanja možganov do imunskega sistema. Razumevanje kompleksnih interakcij med molekularnimi procesi teh mehanizmov je eden od glavnih ciljev biomedicinskih raziskav, s katerimi želimo doseči optimalno preprečevanje, diagnozo in zdravljenje bolezni. Z znanstvenega vidika je pomembno, da raziskovalne metode ne posegajo v biološki sistem med opazovanjem. Najprimernejše orodje za to je optična fluorescenčna mikroskopija daljnjega polja. A v biomedicinski uporabi moramo često pokriti širok razpon prostorskih skal (od nanometrov do mikrometrov in več) in časovnih skal (od mikrosekund do minut ali celo ur) in/ali dolgotrajno slikanje, ki ga dovoljuje le nizka fototoksičnost. Tem zahtevam zaenkrat ni mogoče zadostiti z enim samim mikroskopom, kar predstavlja vrsto izzivov za tehnično infrastrukturo. Te bomo ilustrirali na primeru odziva imunskih celic in organizacije plazemske membrane ter obenem ponudili nov vpogled v možne rešitve

Predavanje bo v angleščini.

Lepo vabljeni!

 

 

 




We invite you to the 22nd Institute colloquium in the academic year 2015/16. The colloquium will be held on Wednesday Avgust 24, 2016 at 1 PM in the main Institute lecture hall, Jamova 39, Ljubljana. To read the abstract click  http://www.ijs.si/ijsw/Koledar_prireditev. Past colloquia are posted on  http://videolectures.net/kolokviji_ijs.

 

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prof. dr. Christian Eggeling

University of Oxford, Oxford, United Kingdom

 

Super-resolution optical microscopy: New insights and remaining tasks

 

Efficient functioning of the human body involves a multi-level synthesis emerging from collective brain activity to the immune system. Understanding the complex interactions of the molecular processes underlying these mechanisms is one of the main objectives of biomedical research in order to achieve optimal prevention, diagnosis, and treatment. Scientifically, it is important that the methods do not influence the biological system during observation. The most suitable tool that can cover all of this is optical far-field fluorescence microscopy. Yet, biomedical applications often demand coverage of a large range of spatial (nanometers to larger than micrometers) and temporal (microseconds to minutes/hours) scales, and/or long acquisition times (low phototoxicity), which can so far not all be covered by a single microscope and puts some challenges on microscope infrastructure. Taking immune cell responses and plasma membrane organization as examples, we outline these challenges but also give new insights into possible solutions.

 

Cordially invited!

 

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