IJS KOLOKVIJ, četrtek, 24. 03. 2016; ob 13. uri; prof. dr. Jacques Prost

[Tanja Debevec]

Vabimo vas na 14. predavanje iz sklopa "Kolokviji na IJS" v letu 2015/16, ki bo v četrtek, 24. marca 2016, ob 13. uri v Veliki predavalnici Instituta »Jožef Stefan«  na Jamovi cesti 39 v Ljubljani. Napovednik predavanja najdete tudi na naslovu http://www.ijs.si/ijsw/Koledar_prireditev, posnetke preteklih predavanj pa na http://videolectures.net/kolokviji_ijs. 

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prof. dr. Jacques Prost

Institut Curie, Pariz, Francija

Mechanobiology Institute, National University of Singapore, Singapur

 

Vloga teorije aktivnih gelov v biologiji

Znaten del mehanike, morfologije in gibanja celic določajo dinamične lastnosti aktinske mreže, ki so posledica delovanja molekularnih motorjev, ter nenehna polimerizacija in depolimerizacija, zaradi katere je vlakna spominjajo na tekalno stezo. Aktinska mreža tvori fizikalni gel z začasnimi in gibljivimi vozlišči. Ta je zaradi makroskopske polarnosti aktinskih vlaken in zaradi dinamičnega prerazporejanja vozlišč, ki ga povzročajo molekularni motorji, bolj kompleksen od običajnih gelov. Pojasnili bomo, kako je mogoče teoretično opisati ta sistem, in predstavili nekaj eksperimentalnih primerov – npr. zaraščanje brazgotine in citokinezo –, s katerimi bomo ilustrirali, kakšen vpogled lahko dobimo z tako analizo. Ker pridemo do enačb z ohranitvenimi zakoni in simetrijo, bi morale veljati tudi za tkiva, če seveda uporabimo primerne ohranitvene zakone. Nadalje bomo pokazali, da se napovedi izpred desetih let skladajo z obnašanjem nematskih epitelijev na strukturiranih povrsinah. 

Predavanje bo v angleščini.

Lepo vabljeni!

 

We invite you to the 14th Institute colloquium in the academic year 2015/16. The colloquium will be held on Thursday March 24, 2016 at 13 PM in the main Institute lecture hall, Jamova 39, Ljubljana. To read the abstract click  http://www.ijs.si/ijsw/Koledar_prireditev. Past colloquia are posted on  http://videolectures.net/kolokviji_ijs.

 

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prof. dr. Jacques Prost

Institut Curie, Paris, France

Mechanobiology Institute, National University of Singapore, Singapore

 

Biological relevance of active gel theory

 

Much of the cell mechanics, morphology and motility is determined by the dynamical properties of an actin network moving under the action of molecular motors and by a continuous process of polymerization/depolymerization called treadmilling. The actin network constitutes a physical gel the cross-links of which are both temporary and mobile. It is more complex than a physical gel in that it has a macroscopic polarity due to the microscopic polarity of actin filaments and in that the cross-links are dynamically redistributed by molecular motors. We will explain how one can propose equations describing this situation and describe a few experimental situations such as cell wound healing and cytokinesis showing what kind of understanding can be obtained from this type of analysis. The equations being obtained on the ground of conservation laws and symmetry, they should also be valid for tissues provided appropriate conservation laws are used. We will further show how predictions made ten years ago are borne out by the behaviour of nematic epithelia on patterned surfaces.

 

Cordially invited!

 

 

 

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