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</o:shapelayout></xml><![endif]--></head><body lang=SL link=blue vlink=purple><div class=WordSection1><p class=MsoNormal>Vabimo vas na 14. predavanje iz sklopa "Kolokviji na IJS" v letu 2015/16, ki bo<span style='color:red'> <b>v četrtek, 24. marca 2016, ob 13. uri </b>v Veliki predavalnici Instituta »Jožef Stefan«<b> </b></span>na Jamovi cesti 39 v Ljubljani. Napovednik predavanja najdete tudi na naslovu <a href="http://www.ijs.si/ijsw/Koledar_prireditev">http://www.ijs.si/ijsw/Koledar_prireditev</a>, posnetke preteklih predavanj<span style='color:blue'> </span>pa na <a href="http://videolectures.net/kolokviji_ijs">http://videolectures.net/kolokviji_ijs</a>. <o:p></o:p></p><p class=MsoNormal style='margin-bottom:12.0pt'>~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~<o:p></o:p></p><p class=MsoNormal><b><span lang=EN-US>prof. dr. Jacques Prost<o:p></o:p></span></b></p><p class=MsoNormal><i><span lang=EN-US>Institut Curie, Pariz, Francija<o:p></o:p></span></i></p><p class=MsoNormal><i><span lang=EN-US>Mechanobiology Institute, National University of Singapore, Singapur<o:p></o:p></span></i></p><p class=MsoNormal><b><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='text-align:center;text-autospace:none'><b><span lang=EN-US style='font-size:14.0pt'>Vloga teorije aktivnih gelov v biologiji<o:p></o:p></span></b></p><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt;text-align:justify'><span lang=EN-GB>Znaten del mehanike, morfologije in gibanja celic dolo</span>č<span lang=EN-GB>ajo dinami</span>č<span lang=EN-GB>ne lastnosti aktinske mreže, ki so posledica delovanja molekularnih motorjev, ter nenehna polimerizacija in depolimerizacija, zaradi katere je vlakna spominjajo na tekalno stezo. Aktinska mreža tvori fizikalni gel z za</span>č<span lang=EN-GB>asnimi in gibljivimi vozli</span>šč<span lang=EN-GB>i. Ta je zaradi makroskopske polarnosti aktinskih vlaken in zaradi dinami</span>č<span lang=EN-GB>nega prerazporejanja vozli</span>šč<span lang=EN-GB>, ki ga povzro</span>č<span lang=EN-GB>ajo molekularni motorji, bolj kompleksen od obi</span>č<span lang=EN-GB>ajnih gelov. Pojasnili bomo, kako je mogo</span>č<span lang=EN-GB>e teoreti</span>č<span lang=EN-GB>no opisati ta sistem, in predstavili nekaj eksperimentalnih primerov – npr. zara</span>šč<span lang=EN-GB>anje brazgotine in citokinezo –, s katerimi bomo ilustrirali, kak</span>š<span lang=EN-GB>en vpogled lahko dobimo z tako analizo. Ker pridemo do ena</span>č<span lang=EN-GB>b z ohranitvenimi zakoni in simetrijo, bi morale veljati tudi za tkiva, </span>č<span lang=EN-GB>e seveda uporabimo primerne ohranitvene zakone. Nadalje bomo pokazali, da se napovedi izpred desetih let skladajo z obna</span>š<span lang=EN-GB>anjem nematskih epitelijev na strukturiranih povrsinah. <o:p></o:p></span></p><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt;text-align:justify'>Predavanje bo v angleščini.<o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt'><b><span style='font-family:"Calibri","sans-serif";color:red'>Lepo vabljeni!</span></b><o:p></o:p></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:black'><o:p> </o:p></span></p><p class=MsoNormal><span style='color:black'>We invite you </span>to the 14th Institute <span style='color:black'>colloquium in the academic year 2015/16. The colloquium will be held </span><b><span style='color:red'>on Thursday March 24, 2016 at 13 PM</span></b><span style='color:red'> in <b>the main Institute lecture hall</b></span><span style='color:black'>, Jamova 39, Ljubljana. To read the abstract click </span><a href="http://www.ijs.si/ijsw/Koledar_prireditev">http://www.ijs.si/ijsw/Koledar_prireditev</a><span style='color:#1F497D'>. </span><span style='color:black'>Past colloquia are posted on</span><span style='color:#1F497D'> </span><a href="http://videolectures.net/kolokviji_ijs">http://videolectures.net/kolokviji_ijs</a><span style='color:#1F497D'>.<o:p></o:p></span></p><p class=MsoNormal><span style='color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal style='margin-bottom:12.0pt'>********************************************<b><o:p></o:p></b></p><p class=MsoNormal><b><span lang=EN-US>prof. dr. Jacques Prost<o:p></o:p></span></b></p><p class=MsoNormal><i><span lang=EN-US>Institut Curie, Paris, France<o:p></o:p></span></i></p><p class=MsoNormal><i><span lang=EN-US>Mechanobiology Institute, National University of Singapore, Singapore<o:p></o:p></span></i></p><p class=MsoNormal><b><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><b><span lang=EN-US style='font-size:16.0pt'>Biological relevance of active gel theory<o:p></o:p></span></b></p><p class=MsoNormal><b><span style='font-size:16.0pt;color:#1F497D'><o:p> </o:p></span></b></p><p class=MsoNormal><span lang=EN-GB>Much of the cell mechanics, morphology and motility is determined by the dynamical properties of an actin network moving under the action of molecular motors and by a continuous process of polymerization/depolymerization called treadmilling. The actin network constitutes a physical gel the cross-links of which are both temporary and mobile. It is more complex than a physical gel in that it has a macroscopic polarity due to the microscopic polarity of actin filaments and in that the cross-links are dynamically redistributed by molecular motors. We will explain how one can propose equations describing this situation and describe a few experimental situations such as cell wound healing and cytokinesis showing what kind of understanding can be obtained from this type of analysis. The equations being obtained on the ground of conservation laws and symmetry, they should also be valid for tissues provided appropriate conservation laws are used. We will further show how predictions made ten years ago are borne out by the behaviour of nematic epithelia on patterned surfaces.<o:p></o:p></span></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><b><span lang=EN-US style='font-size:14.0pt'>Cordially invited!</span></b><o:p></o:p></p><p class=MsoNormal><span lang=EN-US><o:p> </o:p></span></p><p class=MsoNormal><span lang=EN-US><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p></div></body></html>