OPOMNIK: IJS KOLOKVIJ,sreda, 03. 12. 2014; ob 13. uri; prof. dr. Tomislav Domazet-Lošo

[Tanja Debevec]

Vabimo vas na 8. predavanje iz sklopa "Kolokviji na IJS" v letu 2014/15, ki bo v sredo, 03. decembra 2014, ob 13. uri v Veliki predavalnici Instituta »Jožef Stefan«  na Jamovi cesti 39 v Ljubljani. Napovednik predavanja najdete tudi na naslovu http://www.ijs.si/ijsw/Koledar_prireditev, posnetke preteklih predavanj pa na http://videolectures.net/kolokviji_ijs. 

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prof. dr. Tomislav Domazet-Lošo

Laboratory za evolucijsko genetiko, Institut Ruđer Bošković, Zagreb, Hrvaška & Hrvaška katoliška univerza, Zagreb, Hrvaška

 

 

Makroevolucija: Korenine dobrega in zla segajo daleč v preteklost

 

Čeprav je molekularna narava tumorjev pri vretenčarjih dobro raziskana, ostaja njeno evolucijsko poreklo neznano. Posebej zanimivo je, da ni dokazov za naravno pojavljajoče se tumorje v predbilateralnih živalih, kot so spužve in ožigalkarji. Predstavili bomo prvi dokaz za naravne tumorje v dveh vrstah hidre, katerih transkriptom oponaša premike v ekspresiji pri rakavih obolenjih vretenčarjev, kar pomeni, da imajo spontani tumorji globoke evolucijske korenine in da se iz zgodnjih evolucijskih linij večceličnih živali lahko naučimo marsičesa o temeljnih mehanizmih nastanka tumorjev. Obenem bomo predstavili tudi evolucijske korenine kompleksnih možganov vretenčarjev. Filostratigrafska analiza vzorcev genske ekspresije v razvijajoči se ribi zebrici (Danio rerio) je razkrila tri važna obdobja v evolucijski zgodovini vretenčarskih možganov. Najbolj presenetljivo odkritje je, da je že skupni prednik vseh strunarjev imel podobno organizirane možgane kot sedanji vretenčarji. To povezuje izvor vretenčarskih možganov z evolucijsko oboroževalno tekmo, ki se je zgodila v kambriju. 

Predavanje bo v angleščini.

Lepo vabljeni!

 

 

 




We invite you to the 8th Institute colloquium in the academic year 2014/15. The colloquium will be held on Wednesday December 03, 2014 at 1 PM in the main Institute lecture hall, Jamova 39, Ljubljana. To read the abstract click  http://www.ijs.si/ijsw/Koledar_prireditev. Past colloquia are posted on  http://videolectures.net/kolokviji_ijs.

 

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prof. dr. Tomislav Domazet-Lošo

Laboratory of Evolutionary Genetics, Ruđer Bošković Institute, Zagreb, Croatia & Catholic University of Croatia, Zagreb, Croatia

 

 

Macroevolution: The roots of good and evil go deep in time

 

 

Although the molecular nature of tumours is well studied in vertebrates, their evolutionary origin remains unknown. In particular, there is no evidence for naturally occurring tumours in pre-bilaterian animals, such as sponges and cnidarians. We provide the first evidence for naturally occurring tumours in two species of Hydra, which show a transcriptome that mimics expression shifts in vertebrate cancers suggesting that spontaneous tumours have deep evolutionary roots and that early branching animals may be informative in revealing the fundamental mechanisms of tumorigenesis. I will also discuss the evolutionary roots of the complex vertebrate brain. A phylostratigraphic analysis of gene expression patterns in the developing zebrafish (Danio rerio) revealed three important periods in the evolutionary history of the vertebrate brain. The most striking is the finding that the extant vertebrate brain organization was already present in the chordate ancestor. This links the origin of the vertebrate brain with the evolutionary arms race between animal phyla that took place in the Cambrian. 

 

 

Cordially invited!

 

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