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</o:shapelayout></xml><![endif]--></head><body lang=SL link=blue vlink=purple><div class=WordSection1><p class=MsoNormal>Vabimo vas na 8. predavanje iz sklopa "Kolokviji na IJS" v letu 2014/15, ki bo <strong><span style='color:red'>v sredo, 03. decembra 2014, ob 13. uri </span></strong><span style='color:red'>v Veliki predavalnici Instituta »Jožef Stefan«</span> na Jamovi cesti 39 v Ljubljani. Napovednik predavanja najdete tudi na naslovu <a href="http://www.ijs.si/ijsw/Koledar_prireditev">http://www.ijs.si/ijsw/Koledar_prireditev</a>, posnetke preteklih predavanj<span style='color:blue'> </span>pa na <a href="http://videolectures.net/kolokviji_ijs">http://videolectures.net/kolokviji_ijs</a>. <o:p></o:p></p><p class=MsoNormal style='margin-bottom:12.0pt'>~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~<o:p></o:p></p><p class=MsoNormal><b><span lang=EN-US style='mso-fareast-language:ZH-CN'>prof. dr. Tomislav Domazet-Lo</span></b><b><span lang=HR style='mso-fareast-language:ZH-CN'>š</span></b><b><span lang=EN-US style='mso-fareast-language:ZH-CN'>o<o:p></o:p></span></b></p><p class=MsoNormal><i><span lang=EN-US style='mso-fareast-language:ZH-CN'>Laboratory za evolucijsko genetiko, Institut Ruđer Bošković, Zagreb, Hrvaška & Hrvaška katoliška univerza, Zagreb, Hrvaška<o:p></o:p></span></i></p><p class=MsoNormal><b><span style='font-size:14.0pt'><o:p> </o:p></span></b></p><p class=MsoNormal><b><span style='font-size:14.0pt'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><b><span style='font-size:14.0pt'>Makroevolucija: Korenine dobrega in zla segajo daleč v preteklost<o:p></o:p></span></b></p><p class=MsoNormal style='text-align:justify'><span style='font-size:11.0pt;font-family:"Arial","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt;text-align:justify'><span lang=EN-US>Č</span><span lang=EN-GB>eprav je molekularna narava tumorjev pri vreten</span><span lang=EN-US>č</span><span lang=EN-GB>arjih dobro raziskana, ostaja njeno evolucijsko poreklo neznano. Posebej zanimivo je, da ni dokazov za naravno pojavljajo</span><span lang=EN-US>č</span><span lang=EN-GB>e se tumorje v predbilateralnih </span><span lang=EN-US>ž</span><span lang=EN-GB>ivalih, kot so spu</span><span lang=EN-US>ž</span><span lang=EN-GB>ve in </span><span lang=EN-US>ožigalkarji</span><span lang=EN-GB>. Predstavili bomo prvi dokaz za naravne tumorje v dveh vrstah hidre, katerih transkriptom opona</span><span lang=EN-US>š</span><span lang=EN-GB>a premike v ekspresiji pri rakavih obolenjih vreten</span><span lang=EN-US>č</span><span lang=EN-GB>arjev, kar pomeni, da imajo spontani tumorji globoke evolucijske korenine in da se iz </span><span lang=EN-US>zgodnjih evolucijskih linij večceličnih živali </span><span lang=EN-GB>lahko nau</span><span lang=EN-US>č</span><span lang=EN-GB>imo marsi</span><span lang=EN-US>č</span><span lang=EN-GB>esa o temeljnih mehanizmih nastanka tumorjev. Obenem bomo predstavili tudi evolucijske korenine kompleksnih mo</span><span lang=EN-US>ž</span><span lang=EN-GB>ganov vreten</span><span lang=EN-US>č</span><span lang=EN-GB>arjev. Filostratigrafska analiza vzorcev genske ekspresije v razvijajo</span><span lang=EN-US>č</span><span lang=EN-GB>i se ribi zebrici (<i>Danio rerio</i>) je razkrila tri va</span><span lang=EN-US>ž</span><span lang=EN-GB>na obdobja v evolucijski zgodovini vreten</span><span lang=EN-US>č</span><span lang=EN-GB>arskih mo</span><span lang=EN-US>ž</span><span lang=EN-GB>ganov. Najbolj presenetljivo odkritje je, da </span><span lang=EN-US>je že skupni prednik vseh strunarjev imel podobno organizirane možgane kot sedanji vretenčarji</span><span lang=EN-GB>. To povezuje izvor vreten</span><span lang=EN-US>č</span><span lang=EN-GB>arskih mo</span><span lang=EN-US>ž</span><span lang=EN-GB>ganov z evolucijsko oboro</span><span lang=EN-US>ž</span><span lang=EN-GB>evalno tekmo, ki se je zgodila v kambriju. </span><span lang=ES><o:p></o:p></span></p><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt;text-align:justify'>Predavanje bo v angleščini.<o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt'><strong><span style='font-family:"Calibri","sans-serif";color:red'>Lepo vabljeni!</span></strong><strong><span style='font-weight:normal'><o:p></o:p></span></strong></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p><span style='font-size:12.0pt;font-family:"Times New Roman","serif";mso-fareast-language:SL'><br clear=all style='page-break-before:always'></span><p class=MsoNormal><span style='color:black'>We invite you to the 8th Institute colloquium in the academic year 2014/15. The colloquium will be held <b>on Wednesday December 03, 2014 at 1 PM</b> in <b>the main Institute</b></span><b><span style='color:#1F497D'> </span><span style='color:black'>lecture hall</span></b><span style='color:black'>, Jamova 39, Ljubljana. To read the abstract click </span><span style='color:#1F497D'><a href="http://www.ijs.si/ijsw/Koledar_prireditev">http://www.ijs.si/ijsw/Koledar_prireditev</a>. </span><span style='color:black'>Past colloquia are posted on</span><span style='color:#1F497D'> <a href="http://videolectures.net/kolokviji_ijs">http://videolectures.net/kolokviji_ijs</a>.<o:p></o:p></span></p><p class=MsoNormal><span style='color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal style='margin-bottom:12.0pt'>********************************************<b><o:p></o:p></b></p><p class=MsoNormal><b><span lang=EN-US>prof. dr. Tomislav Domazet-Lo</span></b><b><span lang=HR>š</span></b><b><span lang=EN-US>o<o:p></o:p></span></b></p><p class=MsoNormal><i><span lang=EN-US>Laboratory of Evolutionary Genetics, Ruđer Bošković Institute, Zagreb, Croatia & Catholic University of Croatia, Zagreb, Croatia<o:p></o:p></span></i></p><p class=MsoNormal><b><span style='font-size:16.0pt;mso-fareast-language:ZH-CN'><o:p> </o:p></span></b></p><p class=MsoNormal><b><span style='font-size:16.0pt;mso-fareast-language:ZH-CN'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><b><span style='font-size:14.0pt'>Macroevolution: The roots of good and evil go deep in time<o:p></o:p></span></b></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><span lang=EN-GB>Although the molecular nature of tumours is well studied in vertebrates, their evolutionary origin remains unknown. In particular, there is no evidence for naturally occurring tumours in pre-bilaterian animals, such as sponges and cnidarians. We provide the first evidence for naturally occurring tumours in two species of Hydra, which show a transcriptome that mimics expression shifts in vertebrate cancers suggesting that spontaneous tumours have deep evolutionary roots and that early branching animals may be informative in revealing the fundamental mechanisms of tumorigenesis. I will also discuss the evolutionary roots</span><span lang=EN-US> of the complex vertebrate brain. A phylostratigraphic analysis of gene expression patterns in the developing zebrafish (<i>Danio rerio</i>) revealed three important periods in the evolutionary history of the vertebrate brain. The most striking is the finding that the extant vertebrate brain organization was already present in the chordate ancestor. This links the origin of the vertebrate brain with the evolutionary arms race between animal phyla that took place in the Cambrian. <o:p></o:p></span></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal>Cordially invited!<o:p></o:p></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p></div></body></html>