[Solomonov Seminar] 142. Solomonov seminar

[Marko Grobelnik]

Vabim vas na 142. Solomonov seminar, ki bo v torek,
9. marca 2004 ob 13:00 uri v Veliki predavalnici IJS.

Na seminarju bosta Dragan Gamberger in Nada Lavrac
predstavila  strojno ucenja z izkanjem podskupin v podakih
na domeni fukcionalne genomike.

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Dragan Gamberger, Nada Lavrac
Institut Rudjer Boskovic, Institut Jozef Stefan

Subgroup discovery experiments in functional genomics

Functional genomics is a typical scientific discovery domain
characterized by a very large number of attributes (genes)
relative to the number of examples (observations). The danger 
of data overfitting is crucial in such domains. To avoid this 
pitfall and achieve predictor robustness, state-of-art approaches 
construct complex classifiers that combine relatively weak 
contributions of up to thousands of genes (attributes) to 
classify a disease.  The complexity of such classifiers limits 
their transparency and consequently the biological insight they 
can provide. The goal of this study is to apply to this domain 
the methodology of constructing simple yet robust logic-based 
classifiers amenable to direct expert interpretation. The approach 
is based on the subgroup discovery rule learning methodology, 
enhanced by methods of restricting the hypothesis search space 
by exploiting the relevancy of features that enter the rule construction 
process as well as their combinations that form the rules. A multi-class 
functional genomics problem of classifying fourteen cancer types 
based on more than 16000 gene expression values is used to illustrate 
the methodology. Some of the discovered rules allow for novel 
biological interpretations.