<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=windows-1250">
<meta name="Generator" content="Microsoft Word 15 (filtered medium)">
<!--[if !mso]><style>v\:* {behavior:url(#default#VML);}
o\:* {behavior:url(#default#VML);}
w\:* {behavior:url(#default#VML);}
.shape {behavior:url(#default#VML);}
</style><![endif]--><style><!--
/* Font Definitions */
@font-face
        {font-family:"Cambria Math";
        panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
        {font-family:Calibri;
        panose-1:2 15 5 2 2 2 4 3 2 4;}
@font-face
        {font-family:Aptos;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
        {margin:0cm;
        font-size:11.0pt;
        font-family:"Aptos",sans-serif;
        mso-ligatures:standardcontextual;
        mso-fareast-language:EN-US;}
a:link, span.MsoHyperlink
        {mso-style-priority:99;
        color:#467886;
        text-decoration:underline;}
p.MsoNoSpacing, li.MsoNoSpacing, div.MsoNoSpacing
        {mso-style-priority:1;
        margin:0cm;
        font-size:11.0pt;
        font-family:"Calibri",sans-serif;
        mso-fareast-language:EN-US;}
p.Default, li.Default, div.Default
        {mso-style-name:Default;
        mso-style-priority:99;
        margin:0cm;
        text-autospace:none;
        font-size:12.0pt;
        font-family:"Times New Roman",serif;
        color:black;
        mso-fareast-language:EN-US;}
.MsoChpDefault
        {mso-style-type:export-only;
        font-size:10.0pt;
        mso-ligatures:none;}
@page WordSection1
        {size:612.0pt 792.0pt;
        margin:70.85pt 70.85pt 70.85pt 70.85pt;}
div.WordSection1
        {page:WordSection1;}
--></style><!--[if gte mso 9]><xml>
<o:shapedefaults v:ext="edit" spidmax="1028" />
</xml><![endif]--><!--[if gte mso 9]><xml>
<o:shapelayout v:ext="edit">
<o:idmap v:ext="edit" data="1" />
</o:shapelayout></xml><![endif]-->
</head>
<body lang="SL" link="#467886" vlink="#96607D" style="word-wrap:break-word">
<div class="WordSection1">
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;mso-ligatures:none;mso-fareast-language:SL"><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;mso-ligatures:none"><img width="118" height="57" style="width:1.2291in;height:.5937in" id="Picture_x0020_6" src="cid:image001.jpg@01DA8BD9.104CE590"></span><span style="font-size:10.0pt;font-family:"Arial",sans-serif"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-size:28.0pt;font-family:"Arial",sans-serif;color:#105A97">VABILO<o:p></o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#105A97">Nacionalni inštitut za biologijo Vas vabi, da se udeležite seminarja<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:12.0pt;font-family:"Arial",sans-serif;color:#105A97"><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="margin-bottom:6.0pt;mso-para-margin-bottom:.5gd;text-align:center">
<b><span lang="EN-US" style="font-size:18.0pt;font-family:"Arial",sans-serif;color:#2A8C46;letter-spacing:.05pt">»In Situ sequencing applied to colorectal cancer liver metastasis and glioblastoma-PDX«</span></b><span lang="EN-US" style="font-size:18.0pt;font-family:"Arial",sans-serif;color:#2A8C46;letter-spacing:.05pt">,<b><o:p></o:p></b></span></p>
<p class="Default" align="center" style="margin-bottom:6.0pt;mso-para-margin-bottom:.5gd;text-align:center">
<span style="font-family:"Arial",sans-serif;color:#105A97">ki ga bo predstavila<o:p></o:p></span></p>
<p class="Default" align="center" style="text-align:center"><b><span style="font-size:18.0pt;font-family:"Arial",sans-serif;color:#105A97">Maria Escrivá Conde<o:p></o:p></span></b></p>
<p class="Default" align="center" style="text-align:center"><b><span style="font-family:"Arial",sans-serif;color:#105A97">doktorska študentka na Stockholm University in<o:p></o:p></span></b></p>
<p class="Default" align="center" style="text-align:center"><b><span style="font-family:"Arial",sans-serif;color:#105A97">Science for Life Laboratory (Švedska) v laboratoriju prof. Matsa Nilssona.<o:p></o:p></span></b></p>
<p class="Default" align="center" style="text-align:center"><b><span style="font-family:"Aptos",sans-serif;color:#105A97"><o:p> </o:p></span></b></p>
<p class="Default" align="center" style="text-align:center"><img width="214" height="214" style="width:2.2291in;height:2.2291in" id="Picture_x0020_2" src="cid:image002.png@01DA8BD9.104CE590" alt="A person smiling at the camera

Description automatically generated"><b><span style="font-size:16.0pt;font-family:"Aptos",sans-serif;color:#105A97"><o:p></o:p></span></b></p>
<p class="MsoNoSpacing"><span style="font-size:8.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center;line-height:14.0pt;mso-line-height-rule:exactly">
<b><span style="font-size:13.0pt;font-family:"Arial",sans-serif;color:#2A8C46;letter-spacing:.05pt">Seminar bo v sredo, 24. aprila 2024, ob 11. uri<o:p></o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center;text-indent:-7.1pt;line-height:14.0pt;mso-line-height-rule:exactly;vertical-align:baseline">
<b><span style="font-size:13.0pt;font-family:"Arial",sans-serif;color:#2A8C46;letter-spacing:.05pt">na Nacionalnem inštitutu za biologijo, Večna pot 121, Ljubljana, v veliki predavalnici v prvem nadstropju (glavni vhod C/D) in v okolju ZOOM:<span style="background:yellow;mso-highlight:yellow"><o:p></o:p></span></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center;line-height:18.75pt;vertical-align:baseline">
<a href="https://us02web.zoom.us/j/85878676262?pwd=MXBYbWMxNXA0akdNVGs2Y2ttZExkUT09"><span style="font-family:"Arial",sans-serif">https://us02web.zoom.us/j/85878676262?pwd=MXBYbWMxNXA0akdNVGs2Y2ttZExkUT09</span></a><span class="MsoHyperlink"><span style="font-size:12.0pt"><o:p></o:p></span></span></p>
<p class="MsoNormal" align="center" style="margin-bottom:2.0pt;text-align:center;line-height:18.75pt;vertical-align:baseline">
<span lang="EN-US" style="font-family:"Arial",sans-serif;color:#2A8C46;letter-spacing:.05pt">Meeting number: 858 7867 6262, Passcode: 517570</span><span lang="EN-US" style="color:#2A8C46"><o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="margin-bottom:2.0pt;text-align:center;line-height:18.75pt;vertical-align:baseline">
<span lang="EN-US" style="font-family:"Arial",sans-serif;color:#2A8C46;letter-spacing:.05pt"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><b><u><span style="font-family:"Arial",sans-serif;color:#636363">Povzetek v angleškem jeziku:<o:p></o:p></span></u></b></p>
<p class="MsoNormal" style="text-align:justify"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#636363">In this presentation, we will explore the methodology and significance of analyzing In Situ Sequencing (ISS) data in the
 context of colorectal cancer liver metastasis (CRCLM) and glioblastoma (GBM) samples. ISS offers a powerful approach to investigate spatially resolved gene expression patterns within tissues, providing crucial insights into tumor microenvironments and cellular
 interactions. We will discuss the principles of ISS data analysis. Additionally, we will delve into the specific applications of ISS in understanding the molecular mechanisms underlying colorectal cancer liver metastasis and glioblastoma progression. By harnessing
 ISS technology, researchers can uncover novel biomarkers, therapeutic targets, and spatially defined gene expression signatures, ultimately advancing our understanding and treatment strategies for these aggressive malignancies.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span lang="EN-US" style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#636363"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:#636363"><o:p> </o:p></span></p>
<p align="center" style="mso-margin-top-alt:0cm;margin-right:3.25pt;margin-bottom:0cm;margin-left:14.2pt;text-align:center">
<strong><span style="font-size:11.0pt;font-family:"Arial",sans-serif">Vljudno vabljeni! Seminar bo potekal v angleškem jeziku.</span></strong><strong><span style="font-size:11.0pt;font-family:"Aptos",sans-serif"><o:p></o:p></span></strong></p>
<p align="center" style="mso-margin-top-alt:0cm;margin-right:3.25pt;margin-bottom:0cm;margin-left:14.2pt;text-align:center">
<strong><span lang="EN-US" style="font-size:11.0pt;font-family:"Arial",sans-serif;color:#0C3512">You are cordially invited to attend this lecture, which will be held in English.<o:p></o:p></span></strong></p>
<p align="center" style="mso-margin-top-alt:0cm;margin-right:3.25pt;margin-bottom:0cm;margin-left:14.2pt;text-align:center">
<span style="font-size:8.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="margin-left:14.2pt;text-align:center">
<span style="font-family:"Arial",sans-serif;color:#636363">Dodatne informacije: Dr. Barbara Breznik,
</span><a href="mailto:barbara.breznik@nib.si"><span style="font-family:"Arial",sans-serif">barbara.breznik@nib.si</span></a><span style="font-family:"Arial",sans-serif;color:#636363">.<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="margin-left:14.2pt;text-align:center">
<span style="font-family:"Arial",sans-serif;color:#636363"><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="margin-left:14.2pt;text-align:center">
<span style="font-family:"Arial",sans-serif;color:#636363"><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="margin-left:14.2pt;text-align:center">
<!--[if gte vml 1]><v:shapetype id="_x0000_t75" coordsize="21600,21600" o:spt="75" o:preferrelative="t" path="m@4@5l@4@11@9@11@9@5xe" filled="f" stroked="f">
<v:stroke joinstyle="miter" />
<v:formulas>
<v:f eqn="if lineDrawn pixelLineWidth 0" />
<v:f eqn="sum @0 1 0" />
<v:f eqn="sum 0 0 @1" />
<v:f eqn="prod @2 1 2" />
<v:f eqn="prod @3 21600 pixelWidth" />
<v:f eqn="prod @3 21600 pixelHeight" />
<v:f eqn="sum @0 0 1" />
<v:f eqn="prod @6 1 2" />
<v:f eqn="prod @7 21600 pixelWidth" />
<v:f eqn="sum @8 21600 0" />
<v:f eqn="prod @7 21600 pixelHeight" />
<v:f eqn="sum @10 21600 0" />
</v:formulas>
<v:path o:extrusionok="f" gradientshapeok="t" o:connecttype="rect" />
<o:lock v:ext="edit" aspectratio="t" />
</v:shapetype><v:shape id="Picture_x0020_4" o:spid="_x0000_s1027" type="#_x0000_t75" style='position:absolute;left:0;text-align:left;margin-left:-68.25pt;margin-top:61pt;width:588.65pt;height:22.65pt;z-index:251657216;visibility:visible;mso-wrap-style:square;mso-width-percent:0;mso-height-percent:0;mso-wrap-distance-left:9pt;mso-wrap-distance-top:0;mso-wrap-distance-right:9pt;mso-wrap-distance-bottom:0;mso-position-horizontal:absolute;mso-position-horizontal-relative:text;mso-position-vertical:absolute;mso-position-vertical-relative:text;mso-width-percent:0;mso-height-percent:0;mso-width-relative:page;mso-height-relative:page'>
<v:imagedata src="cid:image003.png@01DA8BD9.104CE590" o:title="" />
<w:wrap type="through"/>
</v:shape><![endif]--><![if !vml]><img width="785" height="30" style="width:8.177in;height:.3125in" src="cid:image007.png@01DA8BD9.9917AA40" align="left" hspace="12" v:shapes="Picture_x0020_4"><![endif]><!--[if gte vml 1]><v:shape id="Picture_x0020_3" o:spid="_x0000_s1026" type="#_x0000_t75" alt="A logo with blue dots and black text Description automatically generated" style='position:absolute;left:0;text-align:left;margin-left:-2.6pt;margin-top:1.6pt;width:135pt;height:53pt;z-index:251658240;visibility:visible;mso-wrap-style:square;mso-width-percent:0;mso-height-percent:0;mso-wrap-distance-left:9pt;mso-wrap-distance-top:0;mso-wrap-distance-right:9pt;mso-wrap-distance-bottom:0;mso-position-horizontal:absolute;mso-position-horizontal-relative:text;mso-position-vertical:absolute;mso-position-vertical-relative:text;mso-width-percent:0;mso-height-percent:0;mso-width-relative:page;mso-height-relative:page'>
<v:imagedata src="cid:image005.jpg@01DA8BD9.104CE590" o:title="A logo with blue dots and black text Description automatically generated" />
<w:wrap type="through"/>
</v:shape><![endif]--><![if !vml]><img width="180" height="71" style="width:1.875in;height:.7395in" src="cid:image008.jpg@01DA8BD9.9917AA40" align="left" hspace="12" alt="A logo with blue dots and black text

Description automatically generated" v:shapes="Picture_x0020_3"><![endif]><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
</div>
</body>
</html>