<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=windows-1250">
<meta name="Generator" content="Microsoft Word 15 (filtered medium)">
<!--[if !mso]><style>v\:* {behavior:url(#default#VML);}
o\:* {behavior:url(#default#VML);}
w\:* {behavior:url(#default#VML);}
.shape {behavior:url(#default#VML);}
</style><![endif]--><style><!--
/* Font Definitions */
@font-face
{font-family:"Cambria Math";
panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0cm;
font-size:11.0pt;
font-family:"Calibri",sans-serif;
mso-ligatures:standardcontextual;
mso-fareast-language:EN-US;}
a:link, span.MsoHyperlink
{mso-style-priority:99;
color:#0563C1;
text-decoration:underline;}
p.MsoNoSpacing, li.MsoNoSpacing, div.MsoNoSpacing
{mso-style-priority:1;
margin:0cm;
font-size:11.0pt;
font-family:"Calibri",sans-serif;
mso-fareast-language:EN-US;}
p.Default, li.Default, div.Default
{mso-style-name:Default;
mso-style-priority:99;
margin:0cm;
text-autospace:none;
font-size:12.0pt;
font-family:"Times New Roman",serif;
color:black;
mso-fareast-language:EN-US;}
.MsoChpDefault
{mso-style-type:export-only;
font-size:10.0pt;
mso-ligatures:none;}
@page WordSection1
{size:612.0pt 792.0pt;
margin:70.85pt 70.85pt 70.85pt 70.85pt;}
div.WordSection1
{page:WordSection1;}
--></style><!--[if gte mso 9]><xml>
<o:shapedefaults v:ext="edit" spidmax="1026" />
</xml><![endif]--><!--[if gte mso 9]><xml>
<o:shapelayout v:ext="edit">
<o:idmap v:ext="edit" data="1" />
</o:shapelayout></xml><![endif]-->
</head>
<body lang="SL" link="#0563C1" vlink="#954F72" style="word-wrap:break-word">
<div class="WordSection1">
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-size:34.0pt;color:#105A97">VABILO</span></b><b><span style="font-size:34.0pt;color:#105A97;mso-ligatures:none"><o:p></o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:13.0pt;color:#105A97">Nacionalni inštitut za biologijo Vas vabi, da se udeležite seminarja<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span lang="EN-US" style="font-size:20.0pt;color:#2A8C46;letter-spacing:.05pt">»Metagenomic sequencing reveals the viral landscape in human stool and wastewater samples«</span></b><span lang="EN-US" style="font-size:18.0pt;color:#2A8C46;letter-spacing:.05pt">,<b><o:p></o:p></b></span></p>
<p class="Default" align="center" style="text-align:center"><span style="font-size:13.0pt;font-family:"Calibri",sans-serif;color:#105A97">ki ga bo predstavila<o:p></o:p></span></p>
<p class="Default" align="center" style="margin-top:6.0pt;text-align:center"><b><span style="font-size:20.0pt;font-family:"Calibri",sans-serif;color:#105A97">dr. Sara Javornik Cregeen
<o:p></o:p></span></b></p>
<p class="Default" align="center" style="margin-bottom:4.0pt;text-align:center"><b><span style="font-size:13.0pt;font-family:"Calibri",sans-serif;color:#105A97">vodja skupine za Bioinformatiko,
<o:p></o:p></span></b></p>
<p class="Default" align="center" style="text-align:center"><b><span lang="EN-US" style="font-size:13.0pt;font-family:"Calibri",sans-serif;color:#105A97">Alkek Center for Metagenomics and Microbiome Research<o:p></o:p></span></b></p>
<p class="Default" align="center" style="text-align:center"><b><span lang="EN-US" style="font-size:13.0pt;font-family:"Calibri",sans-serif;color:#105A97">Assistant Professor, Department of Molecular Virology and Microbiology,
<o:p></o:p></span></b></p>
<p class="Default" align="center" style="text-align:center"><b><span lang="EN-US" style="font-size:13.0pt;font-family:"Calibri",sans-serif;color:#105A97">Baylor College of Medicine</span></b><b><span style="font-size:13.0pt;font-family:"Calibri",sans-serif;color:#105A97"><o:p></o:p></span></b></p>
<p class="Default" align="center" style="text-align:center"><b><span style="font-size:8.0pt;font-family:"Calibri",sans-serif;color:#105A97"><o:p> </o:p></span></b></p>
<p class="Default" align="center" style="text-align:center"><span style="font-size:9.0pt;font-family:"Arial",sans-serif"><img width="160" height="206" style="width:1.6666in;height:2.1458in" id="Slika_x0020_1" src="cid:image001.jpg@01DA0276.15702B00" alt="A person wearing glasses and a floral shirt
Description automatically generated"></span><b><span style="font-size:16.0pt;font-family:"Calibri",sans-serif;color:#105A97"><o:p></o:p></span></b></p>
<p class="MsoNoSpacing"><span style="font-size:8.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center;line-height:115%"><b><span style="font-size:13.0pt;line-height:115%;color:#2A8C46;letter-spacing:.05pt">Seminar bo v četrtek, 26. oktobra 2023, ob 15. uri<o:p></o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center;text-indent:-7.1pt;line-height:18.75pt;background:white;vertical-align:baseline">
<b><span style="font-size:13.0pt;color:#2A8C46;letter-spacing:.05pt">v Biološkem središču v Ljubljani, Večna pot 111, v predavalnici B4 in v okolju Webex:<o:p></o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:13.0pt"><a href="https://nib-si.webex.com/nib-si/j.php?MTID=m947ca8a139621e5a20a5a9e0bfec451e">https://nib-si.webex.com/nib-si/j.php?MTID=m947ca8a139621e5a20a5a9e0bfec451e</a><o:p></o:p></span></p>
<p class="MsoNoSpacing" align="center" style="text-align:center"><span class="MsoHyperlink"><span style="font-size:2.0pt;letter-spacing:.05pt"><o:p><span style="text-decoration:none"> </span></o:p></span></span></p>
<p class="MsoNormal" align="center" style="margin-bottom:2.0pt;text-align:center;line-height:18.75pt;background:white;vertical-align:baseline">
<span lang="EN-US" style="font-size:12.0pt;color:#2A8C46;letter-spacing:.05pt">Meeting number: 869 2560 2351, Password: sU2R6eYNK9m (78276396 from video systems)</span><span lang="EN-US" style="font-size:12.0pt;color:#2A8C46"><o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><b><u><span style="font-size:12.0pt;color:#636363">Povzetek:<o:p></o:p></span></u></b></p>
<p class="MsoNormal" style="text-align:justify"><span lang="EN-US" style="font-size:12.0pt;color:#636363">¨The Center for Metagenomics and Microbiome Research (CMMR) at Baylor College of Medicine specializes in providing sequencing and analytical solutions
to big data driven questions in infectious disease and human health. The CMMR has recently made advances in using metagenomics approaches to track viruses of pandemic potential in wastewater1 and understanding the human virome in early life2. 1) Analysis of
wastewater may help us understand the health of populations, yet most current approaches overlook the activity of many human viruses and preclude a deeper understanding of human virome community dynamics. Over a period of 6 months, 363 wastewater samples from
ten distinct sites in two major Texas cities were collected and comprehensive sequencing-based analysis of the virome was performed. Over 450 distinct pathogenic viruses from 28 viral families were observed, most of which have never been detected in such samples.
Sequencing data was correlated to clinical data sets, outlining the public health utility of this approach. In this work the virome of human wastewater is revealed and its potential to improve our understanding of outbreaks, transmission, and its effects on
overall population health discussed. 2) Humans are colonized with commensal bacteria soon after birth, however, less is known about phage communities in early human development. Whole genome shotgun data from the TEDDY study, composed of 12,262 longitudinal
samples from 887 children in 4 countries, was analyzed to assess phage and bacterial dynamics simultaneously. Each child was observed to be colonized by hundreds of different phages during the early years, and phages were more transitory than bacteria. Clear
trends of ecological succession amongst phages were observed and correlated well with putative host bacteria. This work contributes to improved understanding of phage-bacterial relationships and helps reveal new means by which to shape and modulate the microbiome
and its constituents to improve health and reduce disease.¨<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:10.0pt;color:#636363"><o:p> </o:p></span></p>
<p align="center" style="mso-margin-top-alt:0cm;margin-right:3.25pt;margin-bottom:0cm;margin-left:14.2pt;text-align:center">
<strong><span style="font-size:13.0pt;font-family:"Calibri",sans-serif">Vljudno vabljeni! Seminar bo potekal v angleškem jeziku.<o:p></o:p></span></strong></p>
<p align="center" style="mso-margin-top-alt:0cm;margin-right:3.25pt;margin-bottom:0cm;margin-left:14.2pt;text-align:center">
<strong><span lang="EN-US" style="font-size:13.0pt;font-family:"Calibri",sans-serif;color:#525252">You are cordially invited to attend this lecture, which will be held in English.<o:p></o:p></span></strong></p>
<p align="center" style="mso-margin-top-alt:0cm;margin-right:3.25pt;margin-bottom:0cm;margin-left:14.2pt;text-align:center">
<span style="font-size:8.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="margin-left:14.2pt;text-align:center">
<span style="font-size:12.0pt;color:#636363">Dodatne informacije: dr. Maruša Verbič Koprivšek,
</span><span style="font-size:12.0pt"><a href="mailto:marusa.verbickoprivsek@nib.si">marusa.verbickoprivsek@nib.si</a>.<o:p></o:p></span></p>
</div>
</body>
</html>