<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=utf-8">
<meta name="Generator" content="Microsoft Word 14 (filtered medium)">
<!--[if !mso]><style>v\:* {behavior:url(#default#VML);}
o\:* {behavior:url(#default#VML);}
w\:* {behavior:url(#default#VML);}
.shape {behavior:url(#default#VML);}
</style><![endif]--><style><!--
/* Font Definitions */
@font-face
{font-family:"Cambria Math";
panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
{font-family:Cambria;
panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;}
@font-face
{font-family:Tahoma;
panose-1:2 11 6 4 3 5 4 4 2 4;}
@font-face
{font-family:"Open Sans";}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0cm;
margin-bottom:.0001pt;
font-size:12.0pt;
font-family:"Calibri","sans-serif";
mso-fareast-language:EN-US;}
a:link, span.MsoHyperlink
{mso-style-priority:99;
color:blue;
text-decoration:underline;}
a:visited, span.MsoHyperlinkFollowed
{mso-style-priority:99;
color:purple;
text-decoration:underline;}
p.MsoAcetate, li.MsoAcetate, div.MsoAcetate
{mso-style-priority:99;
mso-style-link:"Balloon Text Char";
margin:0cm;
margin-bottom:.0001pt;
font-size:8.0pt;
font-family:"Tahoma","sans-serif";
mso-fareast-language:EN-US;}
span.BalloonTextChar
{mso-style-name:"Balloon Text Char";
mso-style-priority:99;
mso-style-link:"Balloon Text";
font-family:"Tahoma","sans-serif";
mso-fareast-language:EN-US;}
span.EmailStyle19
{mso-style-type:personal;
font-family:"Tahoma","sans-serif";}
span.EmailStyle20
{mso-style-type:personal;
font-family:"Calibri","sans-serif";
color:#1F497D;}
span.EmailStyle21
{mso-style-type:personal-reply;
font-family:"Calibri","sans-serif";
color:#1F497D;}
.MsoChpDefault
{mso-style-type:export-only;
font-size:10.0pt;}
@page WordSection1
{size:612.0pt 792.0pt;
margin:70.85pt 70.85pt 70.85pt 70.85pt;}
div.WordSection1
{page:WordSection1;}
--></style><!--[if gte mso 9]><xml>
<o:shapedefaults v:ext="edit" spidmax="1026" />
</xml><![endif]--><!--[if gte mso 9]><xml>
<o:shapelayout v:ext="edit">
<o:idmap v:ext="edit" data="1" />
</o:shapelayout></xml><![endif]-->
</head>
<body lang="SL" link="blue" vlink="purple">
<div class="WordSection1">
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-US" style="font-size:14.0pt;font-family:"Cambria","serif"">Vabilo na inštitutsko predavanje / Invitation to the institute lecture<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-US" style="font-size:14.0pt;font-family:"Cambria","serif""><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-US" style="font-family:"Cambria","serif""><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-size:16.0pt;font-family:"Cambria","serif"">Prof. Dr. Andreas Bender<o:p></o:p></span></b></p>
<p class="MsoNormal" align="center" style="margin-left:106.2pt;text-align:center;text-indent:35.4pt">
<b><span style="font-size:16.0pt;font-family:"Cambria","serif""><o:p> </o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:14.0pt;font-family:"Cambria","serif"">Centre for Molecular Informatics, University of Cambridge, UK<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-US" style="font-size:14.0pt;font-family:"Cambria","serif"">e-mail:
</span><span style="font-family:"Cambria","serif""><a href="mailto:ab454@cam.ac.uk%20"><span lang="EN-US" style="font-size:14.0pt">ab454@cam.ac.uk</span></a></span><span style="font-size:14.0pt;font-family:"Cambria","serif""><o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span lang="EN-US" style="font-size:16.0pt;font-family:"Cambria","serif""><o:p> </o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span lang="EN-US" style="font-size:16.0pt;font-family:"Cambria","serif"">Ponedeljek / Monday 22. 5. 2017, ob / at 13:00</span></b><span style="font-size:16.0pt;font-family:"Cambria","serif""><o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-US" style="font-size:14.0pt;font-family:"Cambria","serif"">Velika predavalnica Kemijskega inštituta / Great Lecture Hall, National Institute of Chemistry; Hajdrihova 19, Ljubljana</span><span style="font-size:14.0pt;font-family:"Cambria","serif""><o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center;layout-grid-mode:char">
<span lang="EN-US" style="font-size:16.0pt;font-family:"Cambria","serif";color:#660066"><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center;layout-grid-mode:char">
<b><span style="font-size:16.0pt;font-family:"Cambria","serif"">Chemical and Biological Data<o:p></o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center;layout-grid-mode:char">
<b><span style="font-size:14.0pt;font-family:"Cambria","serif"">From Compound Selection to Mode of Action Analysis (and Back Again)<o:p></o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center;layout-grid-mode:char">
<span lang="EN-US" style="font-size:11.0pt;font-family:"Cambria","serif";color:#792D4C"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:11.0pt;font-family:"Cambria","serif"">More and more chemical and biological information is becoming available, both in public databases as well as in company repositories. However, how to
make use of this information in chemical biology and drug discovery settings is much less clear.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:11.0pt;font-family:"Cambria","serif"">In this work, we will discuss how chemical and biological information from different domains – such as compound bioactivity data, pathway annotations
from the bioinformatics domain, and gene expression data – can be used for a variety of purposes, such as the mode-of-action analysis from phenotypic readouts, anticipating compound toxicities in early discovery and during lead optimization based on gene expression
data, and for designing and selecting compounds with the desired bioactivities against a range of protein targets as well as cell lines. Another application of much relevance to screening is the design of screening libraries, where we have explored the impact
of cytotoxicity in such libraries, iterative screening and the utilization of ‘informer sets'. Finally, the modelling of compound mixtures will be discussed in this overview presentation of the work taking place in our research group, where we will present
prospective research projects covering diverse biological systems, such as <i>Plasmodium falciparum</i> screens and others.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;font-family:"Cambria","serif"">1. Koutsoukas A,
<i>et al.</i> <i>J. Proteomics</i> <b>2011</b>, 74, 2554 – 2574. <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;font-family:"Cambria","serif"">2. Drakakis G,
<i>et al.</i> <i>MedChemComm</i> <b>2014</b>, 5, 386 – 396. <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;font-family:"Cambria","serif"">3. Verbist B,
<i>et al.</i> <i>Drug Discov. Today</i> <b>2015</b>, 20, 505 – 513.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;font-family:"Cambria","serif"">4. Van Westen GJP,
<i>et al.</i> <i>PLoS Comp. Biol.</i> <b>2013</b>, 9, e1002899.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;font-family:"Cambria","serif"">5. Cortes-Ciriano I,
<i>et al.</i> <i>Bioinformatics</i> <b>2016</b>, 32, 85 – 95.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;font-family:"Cambria","serif"">6. Mervin, LH,
<i>et al.</i> <i>ACS Chem. Biol.</i> <b>2016</b> <i>(ASAP Article, DOI: 10.1021/acschembio.6b00538)</i><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:9.0pt;font-family:"Cambria","serif"">7. Paricharak S,
<i>et al.</i> <i>ACS Chem. Biol.</i> <b>2016, </b><span style="color:black;background:white">1255 – 1264.<o:p></o:p></span></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:9.0pt;font-family:"Cambria","serif";color:black;background:white">8. Paricharak S,
<i>et al.</i> <i>J. Chem. Inf. Model.</i> <b>2016</b>, 56, 1622 – 1630.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:9.0pt;font-family:"Cambria","serif";color:black;background:white">9. Bulusu KC<i>, et al.</i>
<i>Drug Discov. Today</i> <b>2016</b>, 21, 225 – 238</span><span style="font-family:"Cambria","serif";color:black;background:white">.</span><span style="font-family:"Cambria","serif""><o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:14.0pt;font-family:"Cambria","serif""><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:"Cambria","serif"">info:
<a href="mailto:janez.mavri@ki.si">janez.mavri@ki.si</a><o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-US" style="font-family:"Cambria","serif""><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:"Cambria","serif"">***<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:"Cambria","serif"">Z lepimi pozdravi,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;color:#1F497D"><o:p> </o:p></span></p>
<table class="MsoNormalTable" border="0" cellspacing="0" cellpadding="0" style="border-collapse:collapse">
<tbody>
<tr style="height:18.2pt">
<td width="94" valign="top" style="width:70.65pt;padding:0cm 5.4pt 0cm 5.4pt;height:18.2pt">
<p class="MsoNormal"><span style="font-size:11.0pt;color:#1F497D;mso-fareast-language:SL"> </span><span style="color:#1F497D;mso-fareast-language:SL"><o:p></o:p></span></p>
</td>
<td width="506" valign="top" style="width:379.85pt;padding:0cm 5.4pt 0cm 5.4pt;height:18.2pt">
<p class="MsoNormal" style="line-height:14.0pt"><b><span style="font-size:10.0pt;font-family:"Open Sans";color:#6B6B6E;mso-fareast-language:SL">Brigita Pirc</span></b><b><span style="font-size:11.0pt;color:#1F497D;mso-fareast-language:SL"><o:p></o:p></span></b></p>
<p class="MsoNormal" style="line-height:14.0pt"><span style="font-size:10.0pt;font-family:"Open Sans";color:#6B6B6E;mso-fareast-language:SL">Odnosi z javnostmi /
<i>Public Relations</i></span><span style="color:#1F497D;mso-fareast-language:SL"><o:p></o:p></span></p>
</td>
</tr>
<tr style="height:34.25pt">
<td width="94" valign="top" style="width:70.65pt;padding:0cm 5.4pt 0cm 5.4pt;height:34.25pt">
<p class="MsoNormal" align="right" style="margin-right:-5.6pt;text-align:right"><span style="font-size:11.0pt;color:#1F497D;mso-fareast-language:SL"><img border="0" width="47" height="47" id="Picture_x0020_6" src="cid:image001.png@01D2C41C.ED4E5D70" alt="KI"></span><span style="color:#1F497D;mso-fareast-language:SL"><o:p></o:p></span></p>
</td>
<td width="506" style="width:379.85pt;padding:0cm 5.4pt 0cm 5.4pt;height:34.25pt">
<p class="MsoNormal"><span style="font-size:11.0pt;color:#1F497D;mso-fareast-language:SL"><img border="0" width="225" height="21" id="Picture_x0020_5" src="cid:image002.png@01D2C41C.ED4E5D70" alt="KI"></span><span style="color:#1F497D;mso-fareast-language:SL"><o:p></o:p></span></p>
</td>
</tr>
<tr>
<td width="94" valign="top" style="width:70.65pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal"><span style="font-size:11.0pt;color:#1F497D;mso-fareast-language:SL"> </span><span style="color:#1F497D;mso-fareast-language:SL"><o:p></o:p></span></p>
</td>
<td width="506" valign="top" style="width:379.85pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal" style="line-height:13.0pt"><span style="font-size:10.0pt;font-family:"Open Sans";color:#6B6B6E;mso-fareast-language:SL">Kemijski inštitut /
<i>National Institute of Chemistry </i></span><span style="font-size:11.0pt;color:#1F497D;mso-fareast-language:SL"><o:p></o:p></span></p>
<p class="MsoNormal" style="line-height:13.0pt"><span style="font-size:10.0pt;font-family:"Open Sans";color:#6B6B6E;mso-fareast-language:SL">Hajdrihova 19</span><span style="font-size:11.0pt;color:#1F497D;mso-fareast-language:SL"><o:p></o:p></span></p>
<p class="MsoNormal" style="line-height:13.0pt"><span style="font-size:10.0pt;font-family:"Open Sans";color:#6B6B6E;mso-fareast-language:SL">SI-1000 Ljubljana</span><span style="font-size:11.0pt;color:#1F497D;mso-fareast-language:SL"><o:p></o:p></span></p>
<p class="MsoNormal" style="line-height:13.0pt"><span style="font-size:10.0pt;font-family:"Open Sans";color:#6B6B6E;mso-fareast-language:SL">Slovenija /
<i>Slovenia</i></span><span style="font-size:11.0pt;color:#1F497D;mso-fareast-language:SL"><o:p></o:p></span></p>
<p class="MsoNormal" style="line-height:13.0pt"><span style="font-size:10.0pt;font-family:"Open Sans";color:#6B6B6E;mso-fareast-language:SL">Telefon / Phone: 00386 1 476 02 25</span><span style="font-size:11.0pt;color:#1F497D;mso-fareast-language:SL"><o:p></o:p></span></p>
<p class="MsoNormal" style="line-height:13.0pt"><span style="font-size:10.0pt;font-family:"Open Sans";color:#8DB3E2;mso-fareast-language:SL"><a href="mailto:brigita.pirc@ki.si"><span style="color:#8DB3E2">brigita.pirc@ki.si</span></a></span><span style="font-size:10.0pt;font-family:"Open Sans";color:#6888BD;mso-fareast-language:SL">
</span><span style="font-size:11.0pt;color:#1F497D;mso-fareast-language:SL"><a href="http://www.ki.si/"><span style="font-size:10.0pt;font-family:"Open Sans";color:#6888BD">www.ki.si</span></a><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;color:#1F497D;mso-fareast-language:SL"> </span><span style="color:#1F497D;mso-fareast-language:SL"><o:p></o:p></span></p>
</td>
</tr>
</tbody>
</table>
<p class="MsoNormal"><span style="font-size:11.0pt;color:#1F497D;mso-fareast-language:SL"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-US" style="font-family:"Cambria","serif""><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;color:#1F497D"><o:p> </o:p></span></p>
</div>
</body>
</html>