<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=iso-8859-2">
<meta name="Generator" content="Microsoft Word 14 (filtered medium)">
<!--[if !mso]><style>v\:* {behavior:url(#default#VML);}
o\:* {behavior:url(#default#VML);}
w\:* {behavior:url(#default#VML);}
.shape {behavior:url(#default#VML);}
</style><![endif]--><style><!--
/* Font Definitions */
@font-face
{font-family:"Cambria Math";
panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;}
@font-face
{font-family:Tahoma;
panose-1:2 11 6 4 3 5 4 4 2 4;}
@font-face
{font-family:"Open Sans";}
@font-face
{font-family:"Arial Narrow";
panose-1:2 11 6 6 2 2 2 3 2 4;}
@font-face
{font-family:"Abadi MT Condensed Light";}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin-top:0cm;
margin-right:0cm;
margin-bottom:10.0pt;
margin-left:0cm;
line-height:115%;
font-size:12.0pt;
font-family:"Arial","sans-serif";
mso-fareast-language:EN-US;}
p.MsoFooter, li.MsoFooter, div.MsoFooter
{mso-style-priority:99;
mso-style-link:"Footer Char";
margin:0cm;
margin-bottom:.0001pt;
font-size:12.0pt;
font-family:"Arial","sans-serif";
mso-fareast-language:EN-US;}
p.MsoBodyText, li.MsoBodyText, div.MsoBodyText
{mso-style-priority:99;
mso-style-link:"Body Text Char";
margin-top:0cm;
margin-right:0cm;
margin-bottom:6.0pt;
margin-left:0cm;
line-height:115%;
font-size:12.0pt;
font-family:"Arial","sans-serif";
mso-fareast-language:EN-US;}
p.MsoBodyTextFirstIndent, li.MsoBodyTextFirstIndent, div.MsoBodyTextFirstIndent
{mso-style-priority:99;
mso-style-link:"Body Text First Indent Char";
margin-top:0cm;
margin-right:0cm;
margin-bottom:10.0pt;
margin-left:0cm;
text-indent:18.0pt;
line-height:115%;
font-size:12.0pt;
font-family:"Arial","sans-serif";
mso-fareast-language:EN-US;}
a:link, span.MsoHyperlink
{mso-style-priority:99;
color:blue;
text-decoration:underline;}
a:visited, span.MsoHyperlinkFollowed
{mso-style-priority:99;
color:purple;
text-decoration:underline;}
p.MsoAcetate, li.MsoAcetate, div.MsoAcetate
{mso-style-priority:99;
mso-style-link:"Balloon Text Char";
margin:0cm;
margin-bottom:.0001pt;
font-size:8.0pt;
font-family:"Tahoma","sans-serif";
mso-fareast-language:EN-US;}
span.FooterChar
{mso-style-name:"Footer Char";
mso-style-priority:99;
mso-style-link:Footer;
font-family:"Arial","sans-serif";}
span.BodyTextChar
{mso-style-name:"Body Text Char";
mso-style-priority:99;
mso-style-link:"Body Text";
font-family:"Arial","sans-serif";}
span.BodyTextFirstIndentChar
{mso-style-name:"Body Text First Indent Char";
mso-style-priority:99;
mso-style-link:"Body Text First Indent";
font-family:"Arial","sans-serif";}
span.BalloonTextChar
{mso-style-name:"Balloon Text Char";
mso-style-priority:99;
mso-style-link:"Balloon Text";
font-family:"Tahoma","sans-serif";}
span.EndNoteBibliographyChar
{mso-style-name:"EndNote Bibliography Char";
mso-style-link:"EndNote Bibliography";
font-family:"Calibri","sans-serif";}
p.EndNoteBibliography, li.EndNoteBibliography, div.EndNoteBibliography
{mso-style-name:"EndNote Bibliography";
mso-style-link:"EndNote Bibliography Char";
margin-top:0cm;
margin-right:0cm;
margin-bottom:10.0pt;
margin-left:0cm;
font-size:11.0pt;
font-family:"Calibri","sans-serif";
mso-fareast-language:EN-US;}
p.Abstractbody, li.Abstractbody, div.Abstractbody
{mso-style-name:"Abstract body";
margin-top:0cm;
margin-right:0cm;
margin-bottom:6.0pt;
margin-left:0cm;
text-indent:14.15pt;
font-size:12.0pt;
font-family:"Times New Roman","serif";}
span.EmailStyle28
{mso-style-type:personal;
font-family:"Calibri","sans-serif";
color:windowtext;}
span.EmailStyle29
{mso-style-type:personal-reply;
font-family:"Calibri","sans-serif";
color:#1F497D;}
.MsoChpDefault
{mso-style-type:export-only;
font-size:10.0pt;}
@page WordSection1
{size:612.0pt 792.0pt;
margin:70.85pt 70.85pt 70.85pt 70.85pt;}
div.WordSection1
{page:WordSection1;}
--></style><!--[if gte mso 9]><xml>
<o:shapedefaults v:ext="edit" spidmax="1026" />
</xml><![endif]--><!--[if gte mso 9]><xml>
<o:shapelayout v:ext="edit">
<o:idmap v:ext="edit" data="1" />
</o:shapelayout></xml><![endif]-->
</head>
<body lang="SL" link="blue" vlink="purple">
<div class="WordSection1">
<p class="MsoNormal" align="center" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align:center;line-height:normal">
<span lang="EN-US" style="font-size:14.0pt;font-family:"Arial Narrow","sans-serif"">Vabilo na Preglov kolokvij / Invitation to the Pregl colloquium<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align:center;line-height:normal">
<span lang="EN-US" style="font-family:"Arial Narrow","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align:center;line-height:normal">
<span lang="EN-US" style="font-family:"Arial Narrow","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align:center;line-height:normal;layout-grid-mode:char;text-autospace:none;vertical-align:baseline">
<b><span lang="EN-US" style="font-size:20.0pt;font-family:"Arial Narrow","sans-serif"">Prof. Dr. Vladimir Sklenar<o:p></o:p></span></b></p>
<p class="MsoNormal" align="center" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align:center;line-height:normal">
<span style="font-size:14.0pt;font-family:"Arial Narrow","sans-serif";color:black">Central European Institute of Technology, Masaryk University, Brno, Czech Republic<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align:center;line-height:normal">
<span lang="EN-US" style="font-size:14.0pt;font-family:"Arial Narrow","sans-serif"">Email:
</span><a href="mailto:vladimir.sklenar@ceitec.muni.cz"><span style="font-size:14.0pt;font-family:"Arial Narrow","sans-serif"">vladimir.sklenar@ceitec.muni.cz</span></a><span style="font-size:14.0pt;font-family:"Arial Narrow","sans-serif";color:black"><o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align:center;line-height:normal">
<span lang="EN-US" style="font-size:14.0pt;font-family:"Arial Narrow","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align:center;line-height:normal">
<b><span lang="EN-US" style="font-size:20.0pt;font-family:"Arial Narrow","sans-serif"">Četrtek / Thursday 16. 2. 2017, ob / at 13:00
<o:p></o:p></span></b></p>
<p class="MsoNormal" align="center" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align:center;line-height:normal">
<b><span lang="EN-US" style="font-size:16.0pt;font-family:"Arial Narrow","sans-serif""><o:p> </o:p></span></b></p>
<p class="MsoNormal" align="center" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align:center;line-height:normal">
<span lang="EN-US" style="font-size:14.0pt;font-family:"Arial Narrow","sans-serif"">Velika predavalnica Kemijskega inštituta /
<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align:center;line-height:normal">
<span lang="EN-US" style="font-size:14.0pt;font-family:"Arial Narrow","sans-serif"">Great Lecture Hall, National Institute of Chemistry;
<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align:center;line-height:150%">
<span lang="EN-US" style="font-size:14.0pt;line-height:150%;font-family:"Arial Narrow","sans-serif"">Hajdrihova 19, Ljubljana<b><o:p></o:p></b></span></p>
<p class="EndNoteBibliography" style="margin-bottom:0cm;margin-bottom:.0001pt"><span lang="EN-US" style="font-size:9.0pt;font-family:"Arial Narrow","sans-serif";color:#660066"><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align:center;line-height:normal;layout-grid-mode:char">
<b><span lang="EN-US" style="font-size:16.0pt;font-family:"Arial Narrow","sans-serif";color:#792D4C"><o:p> </o:p></span></b></p>
<p class="MsoNormal" align="center" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align:center;line-height:normal">
<b><span style="font-size:18.0pt;font-family:"Arial Narrow","sans-serif"">Disentangling Puzzles – Atomic resolution Studies
<o:p></o:p></span></b></p>
<p class="MsoNormal" align="center" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align:center;line-height:normal">
<b><span style="font-size:18.0pt;font-family:"Arial Narrow","sans-serif"">of Intrinsically Disordered Proteins</span></b><span style="font-size:18.0pt;font-family:"Arial Narrow","sans-serif""><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:normal;layout-grid-mode:char">
<span lang="EN-US" style="font-size:14.0pt;font-family:"Arial Narrow","sans-serif";color:#792D4C"><o:p> </o:p></span></p>
<p class="Abstractbody" style="text-align:justify;text-indent:0cm"><span lang="EN-US" style="font-family:"Arial Narrow","sans-serif";color:black">As the classical paradigm of structural biology states “one protein - one structure - one function”, it is generally
believed that the protein structure and its function are directly interrelated. Although it is commonly true for a large number of proteins, many of them are biologically active without having a unique and stable 3D structure. Those proteins, which in their
native conditions sample a multitude of diverse conformational states characterized by high spatiotemporal heterogeneity, are most often termed as intrinsically disordered proteins (IDPs) or natively unfolded (UF) proteins. With the growing evidence of their
important roles in fundamental cellular processes, there is an urgent need to characterize the conformational behavior of IDPs at the highest possible level. Among of all available techniques of modern structural biology NMR represents the ultimate tool for
studies of unstructured or partially disordered proteins at atomic resolution.<o:p></o:p></span></p>
<p class="Abstractbody" style="text-align:justify;text-indent:0cm"><span lang="EN-GB" style="font-family:"Arial Narrow","sans-serif";color:black">The lecture will review recent methodology developed in our lab to significantly shorten time needed for thorough
description of unstructured or partially disordered proteins. To facilitate the atomic resolution studies, we have designed a suite of high-dimensional (4D-5D) NMR experiments, which combines
<sup>13</sup>C-direct detection, non-uniform sampling, and non-standard data processing procedures to substantially enhance the attainable resolution. The power of the developed methodology is documented on studies and disorder characterization of 20 kDa delta
subunit of RNA polymerase unique for gram-positive bacteria, 12.8kDa intrinsically disordered WIPs protein having a high content of proline residues (26%) in the sequence, and 49.2 kDa microtubule-associated protein 2c.
<o:p></o:p></span></p>
<p class="Abstractbody" style="text-align:justify;text-indent:0cm"><span lang="EN-GB" style="font-family:"Arial Narrow","sans-serif";color:black"><o:p> </o:p></span></p>
<p class="Abstractbody" style="text-align:justify;text-indent:0cm"><span lang="EN-GB" style="font-family:"Arial Narrow","sans-serif";color:black"><o:p> </o:p></span></p>
<p class="MsoFooter" align="center" style="text-align:center"><span style="font-size:18.0pt;font-family:"Abadi MT Condensed Light"">Vljudno vabljeni / Kindly invited<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align:justify;line-height:normal;layout-grid-mode:char">
<span lang="EN-US" style="font-family:"Arial Narrow","sans-serif";color:black;mso-fareast-language:JA"><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="margin-bottom:0cm;margin-bottom:.0001pt;text-align:center;line-height:normal">
<span lang="EN-US" style="font-size:14.0pt;font-family:"Arial Narrow","sans-serif"">info:
<a href="mailto:janez.plavec@ki.si">janez.plavec@ki.si</a><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;line-height:115%;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;line-height:115%;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<table class="MsoNormalTable" border="0" cellspacing="0" cellpadding="0" style="border-collapse:collapse">
<tbody>
<tr style="height:18.2pt">
<td width="94" valign="top" style="width:70.65pt;padding:0cm 5.4pt 0cm 5.4pt;height:18.2pt">
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:normal">
<span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D;mso-fareast-language:SL"> </span><span style="font-family:"Calibri","sans-serif";color:#1F497D;mso-fareast-language:SL"><o:p></o:p></span></p>
</td>
<td width="506" valign="top" style="width:379.85pt;padding:0cm 5.4pt 0cm 5.4pt;height:18.2pt">
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:14.0pt">
<b><span style="font-size:10.0pt;font-family:"Open Sans";color:#6B6B6E;mso-fareast-language:SL">Brigita Pirc</span></b><b><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D;mso-fareast-language:SL"><o:p></o:p></span></b></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:14.0pt">
<span style="font-size:10.0pt;font-family:"Open Sans";color:#6B6B6E;mso-fareast-language:SL">Odnosi z javnostmi /
<i>Public Relations</i></span><span style="font-family:"Calibri","sans-serif";color:#1F497D;mso-fareast-language:SL"><o:p></o:p></span></p>
</td>
</tr>
<tr style="height:34.25pt">
<td width="94" valign="top" style="width:70.65pt;padding:0cm 5.4pt 0cm 5.4pt;height:34.25pt">
<p class="MsoNormal" align="right" style="mso-margin-top-alt:0cm;margin-right:-5.6pt;margin-bottom:0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:right;line-height:normal">
<span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D;mso-fareast-language:SL"><img border="0" width="47" height="47" id="Picture_x0020_6" src="cid:image001.png@01D282CE.D5798330" alt="KI"></span><span style="font-family:"Calibri","sans-serif";color:#1F497D;mso-fareast-language:SL"><o:p></o:p></span></p>
</td>
<td width="506" style="width:379.85pt;padding:0cm 5.4pt 0cm 5.4pt;height:34.25pt">
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:normal">
<span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D;mso-fareast-language:SL"><img border="0" width="225" height="21" id="Picture_x0020_5" src="cid:image002.png@01D282CE.D5798330" alt="KI"></span><span style="font-family:"Calibri","sans-serif";color:#1F497D;mso-fareast-language:SL"><o:p></o:p></span></p>
</td>
</tr>
<tr>
<td width="94" valign="top" style="width:70.65pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:normal">
<span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D;mso-fareast-language:SL"> </span><span style="font-family:"Calibri","sans-serif";color:#1F497D;mso-fareast-language:SL"><o:p></o:p></span></p>
</td>
<td width="506" valign="top" style="width:379.85pt;padding:0cm 5.4pt 0cm 5.4pt">
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:13.0pt">
<span style="font-size:10.0pt;font-family:"Open Sans";color:#6B6B6E;mso-fareast-language:SL">Kemijski inštitut /
<i>National Institute of Chemistry </i></span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D;mso-fareast-language:SL"><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:13.0pt">
<span style="font-size:10.0pt;font-family:"Open Sans";color:#6B6B6E;mso-fareast-language:SL">Hajdrihova 19</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D;mso-fareast-language:SL"><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:13.0pt">
<span style="font-size:10.0pt;font-family:"Open Sans";color:#6B6B6E;mso-fareast-language:SL">SI-1000 Ljubljana</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D;mso-fareast-language:SL"><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:13.0pt">
<span style="font-size:10.0pt;font-family:"Open Sans";color:#6B6B6E;mso-fareast-language:SL">Slovenija /
<i>Slovenia</i></span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D;mso-fareast-language:SL"><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:13.0pt">
<span style="font-size:10.0pt;font-family:"Open Sans";color:#6B6B6E;mso-fareast-language:SL">Telefon / Phone: 00386 1 476 02 25</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D;mso-fareast-language:SL"><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:13.0pt">
<span style="font-size:10.0pt;font-family:"Open Sans";color:#8DB3E2;mso-fareast-language:SL"><a href="mailto:brigita.pirc@ki.si"><span style="color:#8DB3E2">brigita.pirc@ki.si</span></a></span><span style="font-size:10.0pt;font-family:"Open Sans";color:#6888BD;mso-fareast-language:SL">
</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D;mso-fareast-language:SL"><a href="http://www.ki.si/"><span style="font-size:10.0pt;font-family:"Open Sans";color:#6888BD">www.ki.si</span></a><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:normal">
<span style="font-size:10.0pt;font-family:"Calibri","sans-serif";color:#1F497D;mso-fareast-language:SL"> </span><span style="font-family:"Calibri","sans-serif";color:#1F497D;mso-fareast-language:SL"><o:p></o:p></span></p>
</td>
</tr>
</tbody>
</table>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:normal">
<span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D;mso-fareast-language:SL"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;line-height:115%;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;line-height:115%;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
</div>
</body>
</html>