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<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">Spoštovani,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">prihodnji teden na Kemijskem inštitutu organiziramo predstavitev projekta, s katerim je slovenska ekipa študentov sodelovala na mednarodnem tekmovanju v sintezni
biologiji iGEM 2016 in znova dosegla zavidljiv uspeh.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">Prilagamo vabilo in vas lepo pozdravljamo,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p> </o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><b><span style="font-size:10.0pt;font-family:"Arial","sans-serif";color:#990033">Brigita Pirc</span></b><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><img width="56" height="32" id="_x0000_i1025" src="cid:image002.jpg@01D23B55.27156C20" alt="Description: Description: Description: LOGO EPRUVETE ki">
<o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:9.0pt;font-family:"Arial","sans-serif";color:#1F497D">Kemijski inštitut</span><span style="font-size:9.0pt;font-family:"Calibri","sans-serif";color:#1F497D">
<br>
</span><span style="font-size:9.0pt;font-family:"Arial","sans-serif";color:#1F497D">Hajdrihova 19</span><span style="font-size:9.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><br>
</span><span style="font-size:9.0pt;font-family:"Arial","sans-serif";color:#1F497D">SI-1001 Ljubljana</span><span style="font-size:9.0pt;font-family:"Calibri","sans-serif";color:#1F497D">
<br>
</span><span style="font-size:9.0pt;font-family:"Arial","sans-serif";color:#1F497D">Tel.: + 386 /1/ 4760 - 225</span><span style="font-size:9.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><br>
</span><span style="font-size:9.0pt;font-family:"Arial","sans-serif";color:#1F497D">Fax: + 386 /1/ 4760 - 300</span><span style="font-size:9.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><br>
</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><a href="http://www.ki.si/"><span style="font-size:9.0pt;font-family:"Arial","sans-serif"">http://www.ki.si/</span></a></span><span style="font-size:9.0pt;font-family:"Arial","sans-serif";color:#1F497D">
</span><span style="font-size:9.0pt;color:#1F497D"><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:9.0pt;font-family:"Calibri","sans-serif";color:#1F497D"><br>
</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D">***<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center;line-height:150%"><span style="font-size:24.0pt;line-height:150%;font-family:"Candara","sans-serif"">Vabilo<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center;line-height:150%"><span style="font-size:14.0pt;line-height:150%;font-family:"Candara","sans-serif"">na predstavitev projekta študentske ekipe na tekmovanju iGEM 2016<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-size:36.0pt;font-family:"Candara","sans-serif";color:#993366">Sonicell
<o:p></o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-size:8.0pt;font-family:"Candara","sans-serif";color:#993366"><o:p> </o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-size:16.0pt;font-family:"Candara","sans-serif"">v ponedeljek, 21. novembra 2016 ob 12. uri, v Veliki predavalnici Kemijskega inštituta Ljubljana, Hajdrihova 19<o:p></o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-size:8.0pt;font-family:"Candara","sans-serif""><o:p> </o:p></span></b></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:11.0pt;font-family:"Candara","sans-serif";color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:11.0pt;font-family:"Candara","sans-serif";color:black">Sintezna biologija omogoča spreminjanje lastnosti celic, tako, da se na predvidljiv način odzivajo na signale iz okolice, kar odpira
pot naprednim oblikam zdravljenja. Projekt Sonicel se je lotil dveh ključnih izzivov sintezne biologije – kako doseči hitrejši odziv in kako omogočiti hitro neinvazivno stimulacijo celic v notranjosti organizma.
<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:11.0pt;font-family:"Candara","sans-serif";color:black">Projekt je uspel najti izvirni rešitvi za oba problema, kar predstavlja pomemben preboj v sintezni biologiji. Hitrost odziva celic
smo povečali z dizajnom signalne poti na osnovi cepljenih ortogonalnih proteaz, s čemer so dosegli odziv na kombinacijo zunanjih signalov že v 5-15 minutah, in pokazali, da lahko na ta način izvajamo različne logične operacije v celicah. S proteazami smo tudi
dosegli sproščanje že sintetiziranih proteinov v okolico. Projekt je uspel izboljšati odziv celic na mehanske dražljaje ter na ultrazvok, ki lahko prodre globoko v tkivo, s čemer smo omogočili hitro neinvazivno aktivacijo celic, kar pomembno nadgrajuje optognetiko.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:11.0pt;font-family:"Candara","sans-serif";color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><img border="0" width="527" height="297" id="_x0000_i1026" src="cid:image001.jpg@01D23B55.27156C20"><o:p></o:p></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:11.0pt;font-family:"Candara","sans-serif";color:black">Slovenska ekipa s pokalom za osvojeno 1. mesto na področju Temeljnega napredka
<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:11.0pt;font-family:"Candara","sans-serif";color:black">(Foundational advance) na tekmovanju projektov sintezne biologije iGEM 2016<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:11.0pt;font-family:"Candara","sans-serif";color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:11.0pt;font-family:"Candara","sans-serif";color:black">Člani ekipe: Nik Franko, Rok Krese, Tjaša Plaper in Arne Praznik (Biotehniška fakulteta), Miha Gradišek (Fakulteta za elektrotehniko),
Katja Leben in Estera Merljak (Fakulteta za kemijo in kemijsko tehnologijo), Lidija Magdevska in Žiga Pušnik (Fakulteta za računalništvo in informatiko) ter Kosta Cerović, Nina Jerala in Samo Roškar (Medicinska fakulteta). Mentorji: Mojca Benčina, Tina Lebar,
Jan Lonzarič, Tina Fink, Maja Meško, Fabio Lapenta, Žiga Strmšek in Roman Jerala iz Odseka za sintezno biologijo in imunologijo s Kemijskega inštituta.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:11.0pt;font-family:"Candara","sans-serif";color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:11.0pt;font-family:"Candara","sans-serif";color:black">Projekt je predstavljen na:
<a href="http://2016.igem.org/Team:Slovenia">http://2016.igem.org/Team:Slovenia</a><o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:11.0pt;font-family:"Candara","sans-serif";color:black"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Candara","sans-serif";color:black">Več informacij: prof. Roman Jerala;
<a href="mailto:roman.jerala@ki.si">roman.jerala@ki.si</a> <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Candara","sans-serif";color:black"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:11.0pt;font-family:"Candara","sans-serif";color:black"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><o:p> </o:p></span></p>
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