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<p class="MsoTitle" style="margin:0cm;margin-bottom:.0001pt"><span lang="EN-US" style="font-size:14.0pt;font-family:"Verdana","sans-serif";color:#1F497D;font-weight:normal"><o:p> </o:p></span></p>
<p class="MsoTitle" style="margin:0cm;margin-bottom:.0001pt"><span lang="EN-US" style="font-size:14.0pt;font-family:"Verdana","sans-serif";color:black;font-weight:normal">VABILO NA PREGLOV KOLOKVIJ / INVITATION TO THE PREGL COLLOQUIUM</span><span lang="EN-US" style="font-family:"Verdana","sans-serif";color:black;font-weight:normal"><o:p></o:p></span></p>
<p class="MsoNormal"><b><span lang="EN-US" style="font-size:18.0pt;font-family:"Verdana","sans-serif""><o:p> </o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center;layout-grid-mode:char;text-autospace:none;vertical-align:baseline">
<b><span lang="EN-US" style="font-size:18.0pt;font-family:"Verdana","sans-serif"">Prof. Dr. Kristina Djinović-Carugo<o:p></o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-US" style="font-family:"Verdana","sans-serif"">Department of Structural and Computational Biology, Max F. Perutz Laboratories, University of Vienna, Campus Vienna Biocenter 5, A-1030
Vienna, Austria<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-US" style="font-family:"Verdana","sans-serif""><a href="mailto:kristina.djinovic@univie.ac.at">kristina.djinovic@univie.ac.at</a><o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-US" style="font-family:"Verdana","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal" style="line-height:150%"><b><span lang="EN-US" style="font-size:8.0pt;line-height:150%;font-family:"Verdana","sans-serif""><o:p> </o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center;line-height:150%"><b><span lang="EN-US" style="font-size:16.0pt;line-height:150%;font-family:"Verdana","sans-serif"">Torek / Tuesday 18. 10. 2016, ob / at 13:00
<o:p></o:p></span></b></p>
<h6 style="mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:6.0pt;margin-left:0cm">
<b><span lang="EN-US" style="font-size:12.0pt;font-family:"Verdana","sans-serif"">Velika predavalnica Kemijskega inštituta / Lecture Hall, National Institute of Chemistry; Hajdrihova 19, Ljubljana<o:p></o:p></span></b></h6>
<p class="EndNoteBibliography" style="margin-bottom:0cm;margin-bottom:.0001pt"><span lang="EN-US" style="font-size:12.0pt;font-family:"Verdana","sans-serif";color:#660066"><o:p> </o:p></span></p>
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<b><span lang="EN-US" style="font-size:18.0pt;font-family:"Verdana","sans-serif";color:#792D4C;mso-fareast-language:EN-US">Towards Sarcomeric Z-disk Structure: by Lego Building Blocks</span></b><span lang="EN-US" style="font-size:18.0pt;font-family:"Verdana","sans-serif";color:black;mso-fareast-language:JA"><o:p></o:p></span></p>
<p class="MsoNormal" style="layout-grid-mode:char"><span lang="EN-US" style="font-size:12.0pt;font-family:"Verdana","sans-serif";color:black;mso-fareast-language:JA"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify;layout-grid-mode:char"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Verdana","sans-serif"">The sarcomere is the minimal contractile unit in the cardiac and skeletal muscle, where actin and myosin filaments
slide past each other to generate tension. This molecular machinery is supported by a subset of highly organised cytoskeletal proteins that fulfil architectural, mechanical and signalling functions, including the giant proteins titin, obscurin and nebulin
as well as the cross-linking proteins α-actinin and myomesin. The cross-linking of actin and myosin at the boundaries of their filamentous structures is essential for the muscle integrity and function.</span><span lang="EN-US" style="font-size:12.0pt;font-family:"Verdana","sans-serif"">
In the Z-disks – the lateral boundaries of the sarcomere machinery – the protein α-actinin-2 cross-links antiparallel actin filaments from adjacent sarcomeres, and additionally serves as a binding platform for a number of other Z-disk proteins. In striated
muscle cells, the Z-disk represents a highly organized three-dimensional assembly containing a large directory of proteins orchestrated in a multi-protein complex centered on its major component α-actinin, with still poorly understood hierarchy and three-dimensional
interaction map. On the way to elucidate the molecular structural architecture of the Z-disk, the hierarchy of its assembly and structure-function relationships, we are studying binary and higher order sub-complexes of α-actinin using biophysical, structural
and cell biological approaches. Here we will present our recent data on interaction of muscle α-actinin and filamin C with an adaptor protein FATZ-1, forming a fuzzy complex, and discuss findings in view of muscle Z-disk architecture and assembly.</span><span lang="EN-GB" style="font-size:12.0pt;font-family:"Verdana","sans-serif""><o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify;layout-grid-mode:char"><span lang="EN-GB" style="font-size:8.0pt;font-family:"Verdana","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify;layout-grid-mode:char"><span lang="EN-GB" style="font-size:7.0pt;font-family:"Verdana","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span lang="EN-US" style="font-size:14.0pt;font-family:"Verdana","sans-serif"">Vljudno vabljeni / Kindly invited<o:p></o:p></span></b></p>
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<p class="MsoFooter" align="center" style="text-align:center"><span lang="IT" style="font-size:11.0pt;font-family:"Verdana","sans-serif"">info:
</span><span lang="EN-GB" style="font-family:"Verdana","sans-serif";mso-fareast-language:SL">Marjetka Podobnik (<a href="mailto:marjetka.podobnik@ki.si">marjetka.podobnik@ki.si</a>)</span><span lang="IT" style="font-size:11.0pt;font-family:"Verdana","sans-serif""><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="font-size:14.0pt;font-family:"Verdana","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="FR" style="font-size:11.0pt;font-family:"Calibri","sans-serif""><o:p> </o:p></span></p>
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