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<p class="MsoTitle" style="margin:0cm;margin-bottom:.0001pt"><span style="font-size:9.0pt;font-family:"Verdana","sans-serif";color:black;font-weight:normal"><o:p> </o:p></span></p>
<p class="MsoTitle" style="margin:0cm;margin-bottom:.0001pt"><span style="font-family:"Verdana","sans-serif";color:black;font-weight:normal">VABILO NA PREDAVANJE / INVITATION TO LECTURE<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-size:20.0pt;font-family:"Verdana","sans-serif""><o:p> </o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-size:20.0pt;font-family:"Verdana","sans-serif"">Prof. Dr. Frank Peelman</span></b><span lang="TR" style="font-family:"Arial","sans-serif""><o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span style="font-size:8.0pt;font-family:"Verdana","sans-serif""><o:p> </o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center"><span lang="FR" style="font-family:"Arial","sans-serif"">VIB Medical Biotechnology Center, UGent, Gent, Belgium<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span lang="FR" style="font-family:"Arial","sans-serif""><a href="mailto:frank.peelman@vib-ugent.be">frank.peelman@vib-ugent.be</a><o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><i><span lang="FR" style="font-size:12.0pt;font-family:"Calibri","sans-serif""><o:p> </o:p></span></i></p>
<p class="MsoNormal" align="center" style="text-align:center;line-height:150%"><b><span style="font-size:16.0pt;line-height:150%;font-family:"Verdana","sans-serif"">četrtek / Thursday, 19. 05. 2016, ob / at 15:00<o:p></o:p></span></b></p>
<h6 style="margin:0cm;margin-bottom:.0001pt"><span lang="EN-GB" style="font-size:14.0pt;font-family:"Verdana","sans-serif"">Velika predavalnica Kemijskega inštituta / Lecture Hall at the National Institute of Chemistry; Hajdrihova 19, Ljubljana
<o:p></o:p></span></h6>
<p class="MsoNormal" style="text-align:justify"><b><span lang="EN-GB" style="font-size:18.0pt;font-family:"Verdana","sans-serif";color:#993366"><o:p> </o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center;line-height:150%"><b><span lang="EN-GB" style="font-size:14.0pt;line-height:150%;font-family:"Verdana","sans-serif";color:#993366">Insights in the structure and mechanism of TSLP and MyD88 using classical
and less classical structural biology approaches<o:p></o:p></span></b></p>
<p class="MsoNormal"><span style="font-size:12.0pt;color:black;mso-fareast-language:SL"><o:p> </o:p></span></p>
<p class="MsoNormal" style="line-height:150%"><span style="font-family:"Arial","sans-serif";color:black;mso-fareast-language:SL">Abstract:</span><span style="color:black;mso-fareast-language:SL"><o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify;line-height:150%"><span style="font-size:12.0pt;line-height:150%;font-family:"Arial","sans-serif";color:black;mso-fareast-language:SL">TSLP is a cytokine that plays important roles in epithelial barrier immune
responses, and is central in atopic dermatitis and allergic asthma. We present the crystal structure of the TSLP receptor complex and reveal its mechanism, leading to development of potent inhibitors. MyD88 is an essential signaling adapter of Toll-like receptors
and IL-1 family members, with crucial roles in innate immunity. However, hyperactivating mutations in MyD88 can drive B-cell malignancies. Using massive mutagenesis and the MAPPIT two hybrid system, we identify the interaction surfaces of the TIR domain of
MyD88 for its oligomerization and activation. Using data driven docking, we present a helical MyD88 assembly that helps to explain the activation mechanism of MyD88, its regulation by phosphorylation and its hyperactivation by oncogenic mutations.</span><span style="font-size:12.0pt;line-height:150%;color:black;mso-fareast-language:SL"><o:p></o:p></span></p>
<p class="MsoNormal" style="line-height:150%"><span style="font-size:12.0pt;line-height:150%;color:black;mso-fareast-language:SL"> </span><span lang="FR" style="font-family:"Arial","sans-serif""><o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><b><span lang="EN-US" style="font-size:12.0pt;font-family:"Arial","sans-serif";mso-fareast-language:SL">Vljudno vabljeni! / Kindly invited!<o:p></o:p></span></b></p>
<p class="MsoNormal"><span lang="EN-US" style="font-family:"Verdana","sans-serif""><o:p> </o:p></span></p>
<p class="Default"><o:p> </o:p></p>
<p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Arial","sans-serif";color:black;mso-fareast-language:SL">Info: prof. dr. Roman Jerala</span><span lang="FR" style="font-size:11.0pt">;
</span><span lang="FR" style="font-size:12.0pt;color:blue"><a href="mailto:roman.jerala@ki.si">roman.jerala@ki.si</a><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D;mso-fareast-language:SL"><img border="0" width="56" height="32" id="Picture_x0020_3" src="cid:image001.jpg@01D1AD0D.C02ED5D0" alt="Description: Description: Description: LOGO EPRUVETE ki">
<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="FR" style="font-size:11.0pt;font-family:"Calibri","sans-serif""><o:p> </o:p></span></p>
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