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</o:shapelayout></xml><![endif]--></head><body lang=SL link="#467886" vlink="#96607D" style='word-wrap:break-word'><div class=WordSection1><p class=MsoPlainText><a href="https://dnevi.ijs.si/"><span style='color:windowtext;mso-ligatures:none;text-decoration:none'><img border=0 width=1047 height=309 style='width:10.9062in;height:3.2187in' id="Picture_x0020_1" src="cid:image001.png@01DB9A6C.A4A5B3F0"></span></a><o:p></o:p></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'>Vabimo vas na predavanje v okviru »Kolokvijev IJS« ob letošnjih Dnevih Jožefa Stefana, ki bo <b><u>danes</u>, v torek, 25.</b> <b>marca 2025, ob 13:00</b> v Veliki predavalnici Instituta »Jožef Stefan« na Jamovi cesti 39 v Ljubljani. Predavanje bo <b>v angleščini</b>. Na voljo bodo kava, pijača in prigrizki.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:16.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p> </o:p></span></p><p class=MsoNormal><b><span lang=EN-US style='font-size:16.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'>Kaj povzroča amiotrofično lateralno sklerozo?</span></b><b><span style='font-size:16.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p></o:p></span></b></p><p class=MsoNormal><span style='font-size:16.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p> </o:p></span></p><p class=MsoNormal><b><u><span lang=EN-US style='font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'>prof. dr. Ammar Al-Chalabi</span></u></b><b><u><span style='font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p></o:p></span></u></b></p><p class=MsoNormal><i><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'>King’s College London, Velika Britanija</span></i><i><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p></o:p></span></i></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'>Amiotrofična lateralna skleroza (ALS) je nevrodegenerativna bolezen, ki prizadene zgornje in spodnje motorične nevrone ter vodi do smrti zaradi dihalne odpovedi. Približno 50% bolnikov umre v treh letih po pojavu prvih simptomov, medtem ko jih 80% umre v petih letih. Bolezen običajno prizadene posameznike v srednjem in poznejšem življenjskem obdobju, pri čemer je povprečna starost pojavitve okoli 56 let, z rahlo večjo pojavnostjo pri moških. Čeprav ALS prizadene enega izmed 300 ljudi, njene zaskrbljujoče napovedi dajejo vtis, da gre za redko bolezen. Razumevanje vzrokov ALS je ključno za razvoj učinkovitih terapij. Čeprav je znano, da genetski dejavniki igrajo pomembno vlogo, se vse bolj pojavljajo dokazi o vplivu vnetja, presnove holesterola ter poškodb DNK in transkriptoma. V predavanju bom pojasnil, kako kombinacija genetike, transkriptomike, epigenetike in epidemiologije ponuja jasnejšo sliko o vzrokih in dejavnikih za nastanek ALS, kar nam pomaga pri razvoju novih pristopov k zdravljenju.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p> </o:p></span></p><p class=MsoNormal><b><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'>O predavatelju</span></b><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'>: Ammar Al-Chalabi je direktor Kraljevega centra za nego in raziskave bolezni motoričnih nevronov, sodirektor Raziskovalnega instituta za bolezni motoričnih nevronov Združenega kraljestva ter profesor nevrologije in genetike kompleksnih bolezni v bolnišnici King's College v Londonu. Je namestnik urednika revije Brain</span><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'>.</span><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:10.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'>Napovednik predavanja in posnetke preteklih predavanj najdete na <b>spletni strani »Kolokvijev na IJS«</b> </span><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><a href="https://kolokviji.ijs.si/"><span style='font-size:10.0pt;color:#0563C1'>https://kolokviji.ijs.si/</span></a></span><span style='font-size:10.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'>, posnetke pa tudi posebej na </span><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><a href="https://video.arnes.si/?q=Kolokviji_IJS"><span style='font-size:10.0pt;color:#0563C1'>https://video.arnes.si/?q=Kolokviji_IJS</span></a></span><span style='font-size:10.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'> (zadnje štiri sezone) in </span><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><a href="http://videolectures.net/kolokviji_ijs"><span style='font-size:10.0pt;color:#0563C1'>http://videolectures.net/kolokviji_ijs</span></a></span><span style='font-size:10.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'> (starejši).<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'>______________<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'>We invite you to the lecture in the framework of »JSI Colloquia« on<span style='color:black'> this year's Jožef Stefan days</span>, which will take place <b><u>today</u>, Tuesday, March 25, 2025, at 1:00 PM</b> in the main lecture hall of Jožef Stefan Institute, Jamova cesta 39 in Ljubljana. The lecture will be held <b>in English</b>. Coffee, drinks and snacks will be available.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p> </o:p></span></p><p class=MsoNormal><b><span style='font-size:16.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'>What causes amyotrophic lateral sclerosis?<o:p></o:p></span></b></p><p class=MsoNormal><span style='font-size:16.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p> </o:p></span></p><p class=MsoNormal><b><u><span style='font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'>Prof. Dr. Ammar Al-Chalabi<o:p></o:p></span></u></b></p><p class=MsoNormal><i><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'>King’s College London, United Kingdom</span></i><i><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p></o:p></span></i></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'>Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the upper and lower motor neurons leading to death from respiratory failure. About 50% of patients die within 3 years of first symptoms, and 80% within 5 years. The disease typically affects individuals in middle and late life, with a peak age of onset being around 56 years, and it shows a slight male predominance. Although ALS affects one in every 300 people, its dreadful prognosis means that it appears to be a rare disease. To develop effective therapies, it is essential to understand what causes ALS. While a genetic contribution is known to play a role, growing evidence also points to the involvement of inflammation, cholesterol metabolism, and DNA and transcriptome damage. In my talk, I will explain how a combination of genetics, transcriptomics, epigenetics and epidemiology provides a clearer picture of the causes and modifiers of ALS, which helps us develop new approaches to treatment.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p> </o:p></span></p><p class=MsoNormal><b><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'>About the lecturer</span></b><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'>: Ammar Al-Chalabi is a director of the King's MND Care and Research Centre in London, a co-director of the UK Motor Neuron Disease Research Institute, and a professor of neurology and complex disease genetics at the King's College Hospital in London. He is a deputy editor of the Brain journal.<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:10.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'>The lecture trailer and recordings of past lectures can be found on the <b>website of »JSI colloquia«</b> </span><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><a href="https://kolokviji.ijs.si/en/colloquia/"><span style='font-size:10.0pt;color:#0563C1'>https://kolokviji.ijs.si/en/colloquia/</span></a></span><span style='font-size:10.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'>, and recordings specifically at </span><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><a href="https://video.arnes.si/en/?q=Kolokviji_IJS"><span style='font-size:10.0pt;color:#0563C1'>https://video.arnes.si/en/?q=Kolokviji_IJS</span></a></span><span style='font-size:10.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'> (last four seasons) and </span><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><a href="http://videolectures.net/kolokviji_ijs"><span style='font-size:10.0pt;color:#0563C1'>http://videolectures.net/kolokviji_ijs</span></a></span><span style='font-size:10.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'> (older).<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US'><o:p> </o:p></span></p><p class=MsoPlainText><o:p> </o:p></p></div></body></html>