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</o:shapelayout></xml><![endif]--></head><body lang=SL link="#0563C1" vlink="#954F72" style='word-wrap:break-word'><div class=WordSection1><p class=MsoNormal><a href="https://dnevi.ijs.si/"><span style='color:windowtext;text-decoration:none'><img border=0 width=1246 height=257 style='width:12.9791in;height:2.677in' id="Picture_x0020_1" src="cid:image001.png@01DA7947.0518A0F0" alt="Banner SLO ANG"></span></a><o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal>Vabimo vas na predavanje v okviru »Kolokvijev IJS« ob letošnjih Dnevih Jožefa Stefana, ki bo <b><u>danes</u>, v četrtek, 21.</b> <b>marca 2024, ob 13:00</b> v Veliki predavalnici Instituta »Jožef Stefan« na Jamovi cesti 39 v Ljubljani. Predavanje bo <b>v slovenščini</b>. Na voljo bodo kava, pijača in prigrizki.<o:p></o:p></p><p class=MsoNormal><span style='font-size:16.0pt'><o:p> </o:p></span></p><p class=MsoNormal><b><span lang=EN-US style='font-size:16.0pt'>Živalski strupi – prekletstvo in blagoslov</span></b><b><span style='font-size:16.0pt'><o:p></o:p></span></b></p><p class=MsoNormal><span style='font-size:16.0pt'><o:p> </o:p></span></p><p class=MsoNormal><b><u><span lang=EN-US style='font-size:12.0pt'>prof. dr. Igor Križaj</span></u></b><b><u><span style='font-size:12.0pt'><o:p></o:p></span></u></b></p><p class=MsoNormal><i>Institut »Jožef Stefan«, Ljubljana, Slovenija<o:p></o:p></i></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal>Strupenih vrst živali je več kot 220 tisoč. Vsak posamezen strup je enkratna mešanica, običajno več kot 100 različnih farmakološko aktivnih polipeptidov oziroma toksinov. Zbirka strupov tako obsega na milijone različnih molekul, ki bolj ali manj specifično delujejo na vrsto fizioloških tarč. Poznavanje sestave strupov je seveda ključnega pomena za razvoj učinkovitih postopkov za terapijo zastrupitev. Osvetlil pa bom tudi izjemen pomen živalskih toksinov kot molekulskih orodij v temeljnih raziskavah kompleksnih fizioloških sistemov. Živalski strupi so bogat rezervoar zdravilnih učinkovin in spojin vodnic za razvoj zdravil. Ilustriral bom uporabnost toksinov v medicinski diagnostiki, kmetijstvu in biotehnologiji. Predavanje bom zaključil s predstavitvijo naših odkritij, ki dajejo upanje na preboj v terapiji dveh najbolj perečih patologij današnjega časa, Alzheimerjeve bolezni in venske trombembolije, katerih posledice so glavni vzrok za invalidnost, odvisnost in smrt ljudi.<o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><b>O predavatelju</b>: Igor Križaj je znanstveni svetnik na Institutu »Jožef Stefan«, kjer vodi Odsek za molekularne in biomedicinske znanosti, ter redni profesor biokemije na Univerzi v Ljubljani in na Mednarodni podiplomski šoli Jožefa Stefana. Za svoje znanstvene dosežke je prejel več nagrad, nazadnje Zoisovo nagrado za vrhunske dosežke na področju toksinologije.<o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><span style='font-size:10.0pt'>Napovednik predavanja in posnetke preteklih predavanj najdete na <b>novi spletni strani »Kolokvijev IJS«</b> </span><a href="https://kolokviji.ijs.si/"><span style='font-size:10.0pt'>https://kolokviji.ijs.si/</span></a><span style='font-size:10.0pt'>, posnetke pa tudi posebej na </span><a href="https://video.arnes.si/?hashtag=Kolokviji_IJS"><span style='font-size:10.0pt'>https://video.arnes.si/?hashtag=Kolokviji_IJS</span></a><span style='font-size:10.0pt'> (zadnje tri sezone) in </span><a href="http://videolectures.net/kolokviji_ijs"><span style='font-size:10.0pt'>http://videolectures.net/kolokviji_ijs</span></a><span style='font-size:10.0pt'> (starejši).<o:p></o:p></span></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal>______________<o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal>We invite you to the lecture in the framework of »JSI Colloquia« on<span style='color:black'> this year's Jožef Stefan days</span>, which will take place <b><u>today</u>, Thursday, March 21, 2024, at 1:00 PM</b> in the main lecture hall of Jožef Stefan Institute, Jamova cesta 39 in Ljubljana. The lecture will be held <b>in Slovenian</b>. Coffee, drinks and snacks will be available.<o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><b><span style='font-size:16.0pt'>Animal toxins – curse and blessing<o:p></o:p></span></b></p><p class=MsoNormal><span style='font-size:16.0pt'><o:p> </o:p></span></p><p class=MsoNormal><b><u><span style='font-size:12.0pt'>Prof. dr. Igor Križaj<o:p></o:p></span></u></b></p><p class=MsoNormal><i>Jožef Stefan Institute, Ljubljana, Slovenia<o:p></o:p></i></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal>With over 220 thousand venomous species, each venom is a unique blend, typically containing more than 100 different pharmacologically active polypeptides or toxins. The collection of toxins comprises millions of distinct molecules, each with varying specificity in their effects on physiological targets. Understanding the composition of these venoms is crucial for developing effective treatments for envenomations. Animal toxins also play an exceptional role as molecular tools in fundamental research on complex physiological systems. They serve as a rich reservoir of potential medicinal compounds and contribute to advancements in fields such as medical diagnostics, agriculture, and biotechnology. I will conclude the lecture by presenting groundbreaking discoveries that offer hope for breakthroughs in treating two of today’s most pressing pathologies: Alzheimer’s disease and venous thromboembolism, conditions whose consequences significantly impact people’s lives through disability, dependence, and mortality.<o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><b>About the lecturer</b>: Igor Križaj is a scientific councilor at the Jožef Stefan Institute, where he heads the Department of Molecular and Biomedical Sciences, and a professor of biochemistry at the University of Ljubljana and the Jožef Stefan International Postgraduate School. He received several awards for his scientific achievements, most recently the Zois Award for outstanding achievements in the field of toxinology.<o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><span style='font-size:10.0pt'>The lecture trailer and recordings of past lectures can be found on the <b>new website of »JSI colloquia«</b></span> <a href="https://kolokviji.ijs.si/"><span style='font-size:10.0pt'>https://kolokviji.ijs.si/</span></a><span style='font-size:10.0pt'>, and recordings specifically at </span><a href="https://video.arnes.si/en/?hashtag=Kolokviji_IJS"><span style='font-size:10.0pt'>https://video.arnes.si/en/?hashtag=Kolokviji_IJS</span></a><span style='font-size:10.0pt'> (last three seasons) and </span><a href="http://videolectures.net/kolokviji_ijs"><span style='font-size:10.0pt'>http://videolectures.net/kolokviji_ijs</span></a><span style='font-size:10.0pt'> (older).<o:p></o:p></span></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p></div></body></html>