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</o:shapelayout></xml><![endif]--></head><body link="#0563C1" vlink="#954F72"><div class=WordSection1><p class=MsoNormal style='text-align:justify'><a name="_Hlk50455726"></a><a name="_Hlk41995074"></a><a name="_Hlk41470923"></a><a name="_Hlk20313133"><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk50455726'><span lang=SL>Vabimo vas na 1. predavanje iz sklopa "Kolokviji na IJS" v letu 2021/22, ki bo <strong><span style='color:red'>v sredo, 27. oktobra 2021, ob 13. uri </span></strong><span style='color:red'>v Veliki predavalnici Instituta »Jožef Stefan«</span> na Jamovi cesti 39 v Ljubljani.<o:p></o:p></span></span></span></span></a></p><p class=MsoNormal><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk50455726'><strong><span lang=SL style='font-weight:normal'> </span></strong></span></span></span></span><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk50455726'><strong><span style='font-size:11.0pt;font-family:"Calibri",sans-serif;mso-fareast-language:EN-US;font-weight:normal'><o:p></o:p></span></strong></span></span></span></span></p><p class=MsoNormal><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk50455726'><span lang=SL>Napovednik predavanja najdete tudi na naslovu </span></span></span></span></span><a href="http://www.ijs.si/ijsw/Koledar_prireditev"><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk50455726'><span lang=SL>http://www.ijs.si/ijsw/Koledar_prireditev</span></span></span></span></span><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk50455726'></span></span></span></span></a><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk50455726'><span lang=SL>, posnetke preteklih predavanj<span style='color:blue'> </span>pa na </span></span></span></span></span><a href="http://videolectures.net/kolokviji_ijs"><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk50455726'><span lang=SL>http://videolectures.net/kolokviji_ijs</span></span></span></span></span><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk50455726'></span></span></span></span></a><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk50455726'><span lang=SL>. <o:p></o:p></span></span></span></span></span></p><p class=MsoNormal><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk50455726'><span lang=SL>~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~<br><br></span></span></span></span></span><a name="_Hlk57188111"></a><a name="_Hlk57031912"></a><a name="_Hlk57187882"><span style='mso-bookmark:_Hlk57031912'><span style='mso-bookmark:_Hlk57188111'><span style='mso-bookmark:_Hlk50455726'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><b><span lang=EN-US><o:p></o:p></span></b></span></span></span></span></span></span></a></p><span style='mso-bookmark:_Hlk57187882'></span><p class=MsoNormal><span style='mso-bookmark:_Hlk57031912'><span style='mso-bookmark:_Hlk57188111'><span style='mso-bookmark:_Hlk50455726'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><a name="_Hlk57187910"><b><span lang=EN-US>prof. dr. Saša Svetina <o:p></o:p></span></b></a></span></span></span></span></span></span></p><span style='mso-bookmark:_Hlk57187910'></span><span style='mso-bookmark:_Hlk57031912'></span><p class=MsoNormal><span style='mso-bookmark:_Hlk57188111'><span style='mso-bookmark:_Hlk50455726'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><i><span lang=EN-US>Inštitut za biofiziko, Medicinska fakulteta Univerze v Ljubljani in<o:p></o:p></span></i></span></span></span></span></span></p><p class=MsoNormal><span style='mso-bookmark:_Hlk57188111'><span style='mso-bookmark:_Hlk50455726'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><i><span lang=EN-US>Odsek za teoretično fiziko, Institut »Jožef Stefan«<o:p></o:p></span></i></span></span></span></span></span></p><p class=MsoNormal><span style='mso-bookmark:_Hlk57188111'><span style='mso-bookmark:_Hlk50455726'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><i><span lang=EN-US><o:p> </o:p></span></i></span></span></span></span></span></p><p class=MsoNormal><span style='mso-bookmark:_Hlk57188111'><span style='mso-bookmark:_Hlk50455726'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><i><span lang=EN-US><o:p> </o:p></span></i></span></span></span></span></span></p><p class=MsoNormal align=center style='text-align:center'><span style='mso-bookmark:_Hlk57188111'><span style='mso-bookmark:_Hlk50455726'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><b><span lang=SL style='font-size:14.0pt;font-family:"Cambria",serif;color:#1C1E29'>Zakaj so podelili Nobelovo nagrado za odkritje proteinov Piezo1 in Piezo2<o:p></o:p></span></b></span></span></span></span></span></p><p class=MsoNormal style='text-align:justify'><span style='mso-bookmark:_Hlk57188111'><span style='mso-bookmark:_Hlk50455726'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span lang=SL><o:p> </o:p></span></span></span></span></span></span></p><p class=MsoNormal style='text-align:justify'><span style='mso-bookmark:_Hlk57188111'><span style='mso-bookmark:_Hlk50455726'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span lang=SL><o:p> </o:p></span></span></span></span></span></span></p><span style='mso-bookmark:_Hlk57188111'></span><p class=MsoNormal style='text-align:justify'><span style='mso-bookmark:_Hlk50455726'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><a name="_Hlk57031873"><span lang=SL>Letošnjo Nobelovo nagrado za fiziologijo in medicino so podelili za odkritje senzorjev, ki v koži pretvorijo temperaturne ali mehanske dražljaje v električne signale in tako omogočijo prenos dobljenih informacij v možgane. V predavanju se bom omejil na obravnavo zaznavanja mehanskih dražljajev. Raziskovalna skupina pod vodstvom nagrajenega Ardema Patapoutiana je v delu, objavljenem leta 2010, ki je bilo namenjeno odkritju gena za zaznavo dotika, pokazala, da imata pri tej zaznavi ključno vlogo dva membranska kanala, ki nespecifično prepuščata katione. Poimenovali so ju Piezo1 in Piezo2. Kmalu se je izkazalo, da sta ta proteina vsak zase ali pa tudi skupaj pomembna faktorja tudi pri mnogih drugih fizioloških procesih. To je v desetletju po njunem odkritju privedlo do eksplozije raziskav v okviru različnih znanstvenih in uporabniških ved od teoretične fizike do medicine. Podal bom najprej bibliografske podatke o obsežnosti teh raziskav, nato pa prikazal strukturne posebnosti obravnavanih proteinov, obravnaval njun vpliv na obliko okoliške membrane ter opisal, kaj se v nekaterih primerih ve o mehanizmu njunega delovanja. Podrobneje bom obravnaval vlogo proteina Piezo1 pri rdeči krvni celici. Odkritje proteinov Piezo1 in Piezo2 je privedlo do razlage različnih prej nepojasnjenih dejstev, kar bom ilustriral z bežnim opisom naših raziskav regulacije volumna te celice.<o:p></o:p></span></a></span></span></span></span></p><p class=MsoNormal style='text-align:justify'><span style='mso-bookmark:_Hlk50455726'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk57031873'><span lang=SL><o:p> </o:p></span></span></span></span></span></span></p><p class=MsoNormal style='text-align:justify'><span style='mso-bookmark:_Hlk50455726'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk57031873'><span lang=SL>Predavanje bo v slovenščini.<o:p></o:p></span></span></span></span></span></span></p><span style='mso-bookmark:_Hlk57031873'></span><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt'><span style='mso-bookmark:_Hlk50455726'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><strong><span lang=SL style='color:red'>Lepo vabljeni!</span></strong></span></span></span><strong><span lang=SL style='color:red'><o:p></o:p></span></strong></span></p><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt'><span style='mso-bookmark:_Hlk50455726'><strong><span lang=SL style='color:red'><o:p> </o:p></span></strong></span></p><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt'><span style='mso-bookmark:_Hlk50455726'><strong><span lang=SL style='color:red'><o:p> </o:p></span></strong></span></p><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt'><span style='mso-bookmark:_Hlk50455726'><strong><span lang=SL style='color:red'><o:p> </o:p></span></strong></span></p><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt'><span style='mso-bookmark:_Hlk50455726'><strong><span lang=SL style='color:red'><o:p> </o:p></span></strong></span></p><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt'><span style='mso-bookmark:_Hlk50455726'><strong><span lang=SL style='color:red'><o:p> </o:p></span></strong></span></p><span style='mso-bookmark:_Hlk50455726'></span><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt'><strong><span lang=SL style='color:red'><o:p> </o:p></span></strong></p><p class=MsoNormal><span lang=SL style='font-size:11.0pt;font-family:"Calibri",sans-serif'><o:p> </o:p></span></p></div></body></html>