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</o:shapelayout></xml><![endif]--></head><body link="#0563C1" vlink="#954F72"><div class=WordSection1><p class=MsoNormal style='text-align:justify'><a name="_Hlk50455726"></a><a name="_Hlk20313133"></a><a name="_Hlk41470923"></a><a name="_Hlk41995074"><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>Vabimo vas na 4. predavanje iz sklopa "Kolokviji na IJS" v letu 2020/21, ki bo <strong><span style='color:red'>v petek, 16. aprila 2021, ob 13. uri. </span></strong><b>Predavanje bo v spletnem konferenčnem sistemu Zoom in mu lahko prisostvujete tako, da v brskalnik prenesete naslov </b></span></span></span></span></a><a href="https://uni-lj-si.zoom.us/j/98099345188?pwd=c1M0dHdnNHVDVFc2aC90RktCUHJKUT09"><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'><b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>https://uni-lj-si.zoom.us/j/98099345188?pwd=c1M0dHdnNHVDVFc2aC90RktCUHJKUT09</span></b></span></span></span></span><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'></span></span></span></span></a><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'><b><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>; identifikacijska številka sestanka je 980 9934 5188, geslo pa 876849.</span></b></span></span></span></span><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'><span lang=EN-US style='font-size:12.0pt;font-family:"Times New Roman",serif'><o:p></o:p></span></span></span></span></span></p><p class=MsoNormal><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>Predavanje lahko spremljate tudi na TV IJS kanalu na spletnem naslovu </span></span></span></span></span><a href="http://tv.ijs.si"><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>tv.ijs.si</span></span></span></span></span><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'></span></span></span></span></a><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>.</span></span></span></span></span><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'><span lang=SL style='font-size:12.0pt;font-family:"Times New Roman",serif;mso-fareast-language:SL'><o:p></o:p></span></span></span></span></span></p><p class=MsoNormal><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'><strong><span style='font-size:12.0pt;font-weight:normal'> <o:p></o:p></span></strong></span></span></span></span></p><p class=MsoNormal><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>Napovednik predavanja najdete tudi na naslovu </span></span></span></span></span><a href="http://www.ijs.si/ijsw/Koledar_prireditev"><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>http://www.ijs.si/ijsw/Koledar_prireditev</span></span></span></span></span><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'></span></span></span></span></a><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>, posnetke preteklih predavanj<span style='color:blue'> </span>pa na </span></span></span></span></span><a href="http://videolectures.net/kolokviji_ijs"><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>http://videolectures.net/kolokviji_ijs</span></span></span></span></span><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'></span></span></span></span></a><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>. <o:p></o:p></span></span></span></span></span></p><p class=MsoNormal><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~<br><br></span></span></span></span></span><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'><b><span lang=EN-US style='font-size:12.0pt;font-family:"Times New Roman",serif'><o:p></o:p></span></b></span></span></span></span></p><p class=MsoNormal><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'><a name="_Hlk57188111"></a><a name="_Hlk57031912"></a><a name="_Hlk57187910"><span style='mso-bookmark:_Hlk57031912'><span style='mso-bookmark:_Hlk57188111'><b><span lang=EN-US style='font-size:12.0pt;font-family:"Times New Roman",serif'>prof. dr. Dušan Turk<o:p></o:p></span></b></span></span></a></span></span></span></span></p><p class=MsoNormal><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'><span style='mso-bookmark:_Hlk57187910'><span style='mso-bookmark:_Hlk57031912'><span style='mso-bookmark:_Hlk57188111'><i><span lang=EN-US style='font-size:12.0pt;font-family:"Times New Roman",serif'>Institut Jožef Stefan, Ljubljana<o:p></o:p></span></i></span></span></span></span></span></span></span></p><span style='mso-bookmark:_Hlk57031912'></span><span style='mso-bookmark:_Hlk57187910'></span><p class=MsoNormal><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'><span style='mso-bookmark:_Hlk57188111'><i><span lang=EN-US style='font-family:"Times New Roman",serif'><o:p> </o:p></span></i></span></span></span></span></span></p><p class=MsoNormal><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'><span style='mso-bookmark:_Hlk57188111'><b><span style='font-size:14.0pt;font-family:"Times New Roman",serif;color:#1C1E29'>Presejalni test z rentgensko difrakcijo na kristalih glavne proteaze razkril zaviralce virusa SARS-CoV-2</span></b></span></span></span></span></span><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'><span style='mso-bookmark:_Hlk57188111'><b><span lang=SL style='font-size:14.0pt;font-family:"Times New Roman",serif;color:#1C1E29'><o:p></o:p></span></b></span></span></span></span></span></p><p class=MsoNormal style='text-align:justify'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'><span style='mso-bookmark:_Hlk57188111'><span style='font-size:12.0pt;font-family:"Times New Roman",serif'><o:p> </o:p></span></span></span></span></span></span></p><span style='mso-bookmark:_Hlk57188111'></span><p class=MsoNormal style='text-align:justify'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'><a name="_Hlk57031873"><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>SARS-CoV-2 virus je za človeštvo nov patogeni organizem, na katerega imunski odziv ne najde vedno pravega odziva. Predstavili bomo rezultate raziskave, ki vzbuja upanje, da smo stopili velik korak bližje k zdravilu za COVID-19. Ob nastopu epidemije marca lani se je vzpostavil mednarodni konzorcij tridesetih ustanov pod vodstvom DESY in Univerze v Hamburgu, ki je zastavil masovni presejalni test potencialnih zaviralcev delovanja glavne virusne proteaze (MPro). Difrakcijski podatki kristalov kompleksov so razkrili 40 vezanih substanc; za 29 od njih smo določili strukture in 11 med njimi se je izkazalo za uspešne zaviralce virusa v celičnih kulturah. Izpostavljene substance je smiselno testirati na njihove učinke za blaženje bolezni, njihova struktura pa lahko služi kot izhodiščna substanca v postopkih optimizacije, ki bodo lahko privedle do učinkovin, ki bodo ustavile delovanje molekul MPro v pacientih. Uporaba učinkovin v presejalnem testu takšnega obsega je premaknile meje mogočega. Kaže na to, da je število učinkovin v uporabi dovolj veliko, da se med njimi najde nove uporabe, in hkrati na to, da timski pristop ob uporabi sodobne kristalografije lahko pomeni začetek novega obdobja ob iskanju zdravil v primerih zdravstvenih izrednih stanj. <o:p></o:p></span></a></span></span></span></span></p><p class=MsoNormal style='text-align:justify'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'><span style='mso-bookmark:_Hlk57031873'><span style='font-size:12.0pt;font-family:"Times New Roman",serif;mso-fareast-language:SL'><o:p> </o:p></span></span></span></span></span></span></p><p class=MsoNormal style='text-align:justify'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'><span style='mso-bookmark:_Hlk57031873'><span style='font-size:12.0pt;font-family:"Times New Roman",serif'>Predavanje bo v slovnščini.<o:p></o:p></span></span></span></span></span></span></p><span style='mso-bookmark:_Hlk57031873'></span><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt'><span style='mso-bookmark:_Hlk41995074'><span style='mso-bookmark:_Hlk41470923'><span style='mso-bookmark:_Hlk20313133'><span style='mso-bookmark:_Hlk50455726'><strong><span style='font-size:12.0pt;color:red'>Lepo vabljeni!</span></strong></span></span></span></span><span style='mso-bookmark:_Hlk50455726'><strong><span style='font-size:12.0pt;color:red'><o:p></o:p></span></strong></span></p><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt'><span style='mso-bookmark:_Hlk50455726'><strong><span style='font-size:12.0pt;color:red'><o:p> </o:p></span></strong></span></p><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt'><span style='mso-bookmark:_Hlk50455726'><strong><span style='font-size:12.0pt;color:red'><o:p> </o:p></span></strong></span></p><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt'><span style='mso-bookmark:_Hlk50455726'><strong><span style='font-size:12.0pt;color:red'><o:p> </o:p></span></strong></span></p><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt'><span style='mso-bookmark:_Hlk50455726'><strong><span style='font-size:12.0pt;color:red'><o:p> </o:p></span></strong></span></p><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt'><span style='mso-bookmark:_Hlk50455726'><strong><span style='color:red'><o:p> </o:p></span></strong></span></p><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt'><span style='mso-bookmark:_Hlk50455726'><strong><span style='color:red'><o:p> </o:p></span></strong></span></p><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt'><span style='mso-bookmark:_Hlk50455726'><strong><span style='color:red'><o:p> </o:p></span></strong></span></p><span style='mso-bookmark:_Hlk50455726'></span><p class=MsoNormal><span style='font-family:"Times New Roman",serif'><o:p> </o:p></span></p></div></body></html>