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</o:shapelayout></xml><![endif]--></head><body lang=SL link="#0563C1" vlink="#954F72"><div class=WordSection1><p class=MsoNormal>Spoštovani!<o:p></o:p></p><p class=MsoNormal><span style='color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal>Vabimo vas na 24. predavanje iz sklopa “Kolokviji na IJS” v letu 2016/17, ki bo <b><span style='color:red'>v sredo, 30. avgusta 2017</span></b><span style='color:red'> v Veliki predavalnici Instituta »Jožef Stefan« </span>na Jamovi cesti 39 v Ljubljani. Napovednik predavanja najdete na naslovu <a href="http://www.ijs.si/ijsw/Koledar_prireditev">http://www.ijs.si/ijsw/Koledar_prireditev</a>, posnetke preteklih predavanj pa na <a href="http://videolectures.net/kolokviji_ijs">http://videolectures.net/kolokviji_ijs</a>. <o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><b>Dr. Jernej Ule<o:p></o:p></b></p><p class=MsoNormal><i>The Francis Crick Institute and UCL Institute of Neurology, London, UK<o:p></o:p></i></p><p class=MsoNormal><b>Triki, ki jih naše celice uporabljajo, da svoje gene izrazijo v možganih, in kako na to vpliva staranje / Tricks that our cells use to express their genes in the brain, and how aging affects this<o:p></o:p></b></p><p class=MsoNormal><b><o:p> </o:p></b></p><p class=MsoNormal>Dr. Jernej Ule je slovenski raziskovalec, ki je do zdaj edini pridobil dvakratno finančno podporo s strani Evropskega raziskovalnega sveta (European Research Council, ERC). V Veliki Britaniji uspešno vodi laboratorij na inštitutu Francis Crick ter Oddelek za molekularno nevroznanost na Inštitutu UCL za nevrologijo. Raziskovalna skupina pod vodstvom dr. Uleta raziskuje, kako so vzroki bolezni motoričnih nevronov povezani s procesom staranja človeških možganov.<o:p></o:p></p><p class=MsoNormal>Dogodek organizirata Evro-sredozemska univerza (EMUNI) in Institut “Jožef Stefan” v sklopu projekta ERC=Science2, vseevropske komunikacijske kampanje z namenom približevanja perečih tematik v znanosti širši javnosti.<o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><i>Program:<o:p></o:p></i></p><p class=MsoNormal>12.15 – Pogostitev in srečanje z dr. Jernejem Uletom v Galeriji Instituta “Jožef Stefan”<o:p></o:p></p><p class=MsoNormal>13.00 – Predavanje in vprašanja<o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal>Predavanje bo v angleščini.<o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal>Abstract of the lecture:<o:p></o:p></p><p class=MsoNormal>Each RNA in our cells is coated by dozens, if not hundreds of RNA-binding proteins. To understand how these proteins act in our cells, we obtain detailed maps of their RNA binding sites. For this purpose, we developed the nucleotide-resolution UV crosslinking and immunoprecipitation (iCLIP) and a related method called hybrid iCLIP (hiCLIP), which identify protein-RNA and RNA-RNA contacts. I will describe how these methods opened a new window into the diverse mechanisms that enable cells to regulate their gene expression.<o:p></o:p></p><p class=MsoNormal>Mutations in genes encoding RNA-binding proteins can cause motor neuron disease, an age-related neurodegenerative disease. We wish to understand how the cause of this disease is linked to the process of aging in human brain. For this purpose, we characterized gene expression across 10 human brain regions from 480 individuals ranging in age from 16 to 106. We found that the fate of each cell type and each brain region is affected by aging, but in different ways. I will discuss the role that protein-RNA complexes play in regulating such changes in cellular fates, and how this could be important for motor neuron disease.<o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><b><span style='color:red'>Lepo vabljeni!<o:p></o:p></span></b></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p></div></body></html>