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</o:shapelayout></xml><![endif]--></head><body lang=SL link=blue vlink=purple><div class=WordSection1><p class=MsoNormal>Vabimo vas na 21. predavanje iz sklopa "Kolokviji na IJS" v letu 2015/16, ki bo <b><span style='color:red'>v sredo, 29. junija 2016, ob 13. uri </span></b><span style='color:red'>v Veliki predavalnici Instituta ÂťJoĹžef StefanÂŤ</span> na Jamovi cesti 39 v Ljubljani. Napovednik predavanja najdete tudi na naslovu <a href="http://www.ijs.si/ijsw/Koledar_prireditev">http://www.ijs.si/ijsw/Koledar_prireditev</a>, posnetke preteklih predavanj<span style='color:blue'> </span>pa na <a href="http://videolectures.net/kolokviji_ijs">http://videolectures.net/kolokviji_ijs</a>. <o:p></o:p></p><p class=MsoNormal style='margin-bottom:12.0pt'>~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~<o:p></o:p></p><p class=MsoNormal><b><span lang=EN-US style='mso-fareast-language:ZH-CN'>prof. dr. Orly Alter <o:p></o:p></span></b></p><p class=MsoNormal><i><span lang=EN-US style='mso-fareast-language:ZH-CN'>Univerza v Uti, ZdruĹžene drĹžave Amerike<o:p></o:p></span></i></p><p class=MsoNormal><b><span style='font-size:14.0pt'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><b><span lang=EN-US style='font-size:14.0pt'>Multitenzorske dekompozicije za personalizirano diagnostiko in prognostiko raka<o:p></o:p></span></b></p><p class=MsoNormal style='text-align:justify'><span style='font-size:11.0pt;font-family:"Arial",sans-serif'><o:p> </o:p></span></p><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt;text-align:justify'><span lang=EN-US>Razvijamo nove matematiÄne okvire, s katerimi je mogoÄe napraviti, Äesar nobena druga metoda ne zmore, namreÄ ustvariti en sam koherentni model iz veÄ veÄdimenzionalnih mnoĹžic podatkov, znanih kot tenzorjev. Ti okviri - primerjalne spektralne dekompozicije - so posploĹĄitve tistih, na katerih leĹži teoretiÄni opis fizikalnega sveta, in z njimi primerjamo mnoĹžice podatkov, ki opisujejo razliÄne vidike izbrane bolezni, kot so genomski profili veÄ vrst celic v isti skupini bolnikov, izmerjeni veÄkrat z razliÄnimi metodami. Z uporabo kompleksne strukture in ne poenostavljanjem teh mnoĹžic podatkov ti okviri omogoÄajo razlikovanje vzorcev sprememb DNA, do katerih pride le v tumorskih genomih, od tistih pri normalnih celicah v telesu ter od variacij, ki so posledica eksperimentalnih nedoslednosti. PriÄakujemo, da bodo vzorci, ki jih odkrivamo v podatkih, lahko ponudili odgovore na odprta vpraĹĄanja v zvezi s povezavo med tumorskim genomom in razvojem bolezni pri bolniku. Nedavna primerjava genomov tumorskih in normalnih celic v skupinah bolnikov z rakom na jajÄnikih oziroma z glioblastomom je razkrila vzorce sprememb v ĹĄtevilu kopij DNA, ki so bile korelirane z bolnikovo moĹžnostjo za preĹživetje in odzivom na kemoterapijo. Zadnja tri desetletja je najboljĹĄi prediktor preĹživetja pri raku na jajÄnikih stadij tumorja; Äeprav je veÄ kot Äetrtina tumorjev na jajÄnikih odporna na primarno kemoterapijo na osnovi platine, ni nobene diagnostiÄne metode, s katero bi pred terapijo lahko razlikovali med odpornimi in odzivnimi tumorji. Zadnjih pet desetletij je najboljĹĄi prognostiÄni indikator pri glioblastomu bolnikova starost ob diagnozi. Podatki o raku na jajÄnikih in glioblastomu so bili objavljeni, a vzorci so ostali neznani, dokler jih nismo analizirali s primerjalno spektralno dekompozicijo. Po eksperimentalni revalidaciji bomo odkrite vzorce ponudili klinikam, da jih bodo lahko uporabili pri personaliziranih diagnostiÄnih in prognostiÄnih patoloĹĄkih laboratorijskih testih, s katerimi bo mogoÄe napovedati bolnikovo moĹžnost prezivetja in odziv na terapijo ter tako pomagati zdravnikom ustrezno prilagoditi zdravljenje.<o:p></o:p></span></p><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt;text-align:justify'>Predavanje bo v angleĹĄÄini.<o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt'><b><span style='font-family:"Calibri",sans-serif;color:red'>Lepo vabljeni!</span></b><o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p><span style='font-size:12.0pt;font-family:"Times New Roman",serif;mso-fareast-language:SL'><br clear=all style='page-break-before:always'></span><p class=MsoNormal><span style='color:black'>We invite you to the 21th Institute colloquium in the academic year 2015/16. The colloquium will be held </span><b><span style='color:red'>on Wednesday June 29, 2016 at 1 PM</span></b><span style='color:red'> in <b>the main Institute lecture hall</b></span><span style='color:black'>, Jamova 39, Ljubljana. To read the abstract click </span><span style='color:#1F497D'><a href="http://www.ijs.si/ijsw/Koledar_prireditev">http://www.ijs.si/ijsw/Koledar_prireditev</a>. </span><span style='color:black'>Past colloquia are posted on</span><span style='color:#1F497D'> <a href="http://videolectures.net/kolokviji_ijs">http://videolectures.net/kolokviji_ijs</a>.<o:p></o:p></span></p><p class=MsoNormal><span style='color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal style='margin-bottom:12.0pt'>********************************************<b><o:p></o:p></b></p><p class=MsoNormal><b><span lang=EN-US>prof. dr. Orly Alter <o:p></o:p></span></b></p><p class=MsoNormal><i><span lang=EN-US>University of Utah, United States of America<o:p></o:p></span></i></p><p class=MsoNormal><b><span style='font-size:16.0pt;mso-fareast-language:ZH-CN'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><b><span lang=EN-US style='font-size:16.0pt'>Multi-Tensor Decompositions for Personalized Cancer Diagnostics and Prognostics<o:p></o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><o:p> </o:p></p><p class=MsoNormal align=center style='text-align:center'><o:p> </o:p></p><p class=MsoNormal><span lang=EN-US>We are developing new mathematical frameworks to do what no others currently can, that is, create a single coherent model from multiple high-dimensional datasets, known as tensors. The frameworks â comparative spectral decompositions â generalize those that underlie the theoretical description of the physical world. We are using the frameworks to compare and contrast datasets recording different aspects of a single disease, such as genomic profiles of multiple cell types from the same set of patients, measured more than once by several different methods. By using the complex structure of the datasets, rather than simplifying them as is commonly done, the frameworks enable the separation of patterns of DNA alterations â which occur only in the tumor genomes â from those that occur in the genomes of normal cells in the body, and from variations caused by experimental inconsistencies. The patterns that we uncover in the data are expected to offer answers to the open question of the relation between a tumor's genome and a patientâs outcome. For example, recent comparisons of the genomes of tumor and normal cells from the same sets of ovarian and, separately, glioblastoma brain cancer patients uncovered patterns of DNA copy-number alterations that were found to be correlated with a patientâs survival and response to chemotherapy. For three decades prior, the best predictor of ovarian cancer survival was the tumor's stage; more than a quarter of ovarian tumors are resistant to the platinum-based chemotherapy, the first-line treatment, yet no diagnostic existed to distinguish resistant from sensitive tumors before the treatment. For five decades prior, the best prognostic indicator of glioblastoma was the patient's age at diagnosis. The ovarian and brain cancer data were published, but the patterns remained unknown until the team applied their comparative spectral decompositions. Pending experimental revalidation, we will bring the patterns that we uncover to the clinic, to be used in personalized diagnostic and prognostic pathology laboratory tests. The tests would predict a patientâs survival and response to therapy, and doctors could tailor treatment accordingly.<o:p></o:p></span></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal>Cordially invited!<o:p></o:p></p></div></body></html>