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</o:shapelayout></xml><![endif]--></head><body lang=SL link=blue vlink=purple><div class=WordSection1><p class=MsoNormal>Vabimo vas na 15. predavanje iz sklopa "Kolokviji na IJS" v letu 2014/15, ki bo <b><span style='color:red'>v petek, 25. marca 2016, ob 13. uri </span></b><span style='color:red'>v Veliki predavalnici Instituta ÂťJoĹžef StefanÂŤ</span> na Jamovi cesti 39 v Ljubljani. Napovednik predavanja najdete tudi na naslovu <a href="http://www.ijs.si/ijsw/Koledar_prireditev">http://www.ijs.si/ijsw/Koledar_prireditev</a>, posnetke preteklih predavanj<span style='color:blue'> </span>pa na <a href="http://videolectures.net/kolokviji_ijs">http://videolectures.net/kolokviji_ijs</a>. <o:p></o:p></p><p class=MsoNormal style='margin-bottom:12.0pt'>~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~<o:p></o:p></p><p class=MsoNormal align=center style='text-align:center'><b><i><o:p> </o:p></i></b></p><p class=MsoNormal align=center style='text-align:center'><b><i><o:p> </o:p></i></b></p><p class=MsoNormal align=center style='text-align:center'><b><span style='font-size:14.0pt'>prof. dr. Borut Ĺ trukelj<o:p></o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><i>Institut JoĹžef Stefan<o:p></o:p></i></p><p class=MsoNormal align=center style='text-align:center'><b><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><b><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='mso-margin-top-alt:auto;margin-bottom:12.0pt;text-align:center'><b><span style='font-size:14.0pt'>Rekombinantni probiotiki â alternativna bioloĹĄka zdravila z vnosom uÄinkovin v prebavila <o:p></o:p></span></b></p><p class=MsoNormal align=center style='mso-margin-top-alt:auto;margin-bottom:12.0pt;text-align:center'><b><span style='font-size:14.0pt'><o:p> </o:p></span></b></p><p class=MsoNormal style='text-align:justify'><span style='font-family:"Cambria","serif";mso-fareast-language:EN-US'>BioloĹĄka zdravila predstavljajo v zadnjih tridesetih letih velik medicinsko-tehnoloĹĄki preboj v tarÄnem zdravljenju razliÄnih obolenj. Izjemne uspehe izkazujejo monoklonska protitelesa, ki predstavljajo najveÄjo podskupino bioloĹĄkih zdravil. V razvoju so trenutno Ĺže razliÄne strukturne izpeljave monoklonskih protiteles tretje generacije. Skoraj vsa so namenjena sistemskemu vnosu ne glede na mesto delovanja v organizmu. NajveÄ protiteles je narejenih proti rakavim obolenjem in kroniÄnim vnetnim boleznim. Z namenom razviti alternativna bioloĹĄka zdravila, ki bi delovala lokalno v prebavilih, smo pripravili sistem z uporabo mleÄnokislinskih bakterij. Pri tem smo izkoristili moĹžnost izraĹžanja rekombinantnih proteinov, ki delujejo kot bioloĹĄka zdravila, na povrĹĄini mleÄnokislinskih bakterij, ki so nosilci bioloĹĄke zdravilne uÄinkovine. Tako smo razvili sistem za inhibicijo delovanja TNFalfa, ki je en od poglavitnih vzrokov poslabĹĄanja stanja pri ulceroznem kolitisu in Crohnovi bolezni. Na osnovi eksperimentalnih rezultatov je bil skupini podeljen tudi patent v ZdruĹženih drĹžavah Amerike. V predavanju bomo prikazali pot razvoja takega sistema in moĹžnosti uporabe v farmaciji, medicini in biotehnologiji.<o:p></o:p></span></p><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt'>Predavanje bo v slovenĹĄÄini.<o:p></o:p></p><p class=MsoNormal align=center style='mso-margin-top-alt:auto;margin-bottom:12.0pt;text-align:center'><b><span style='color:red'>Lepo vabljeni!</span></b><o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p></div></body></html>