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</o:shapelayout></xml><![endif]--></head><body lang=SL link=blue vlink=purple><div class=WordSection1><p class=MsoNormal>Vabimo vas na 15. predavanje iz sklopa "Kolokviji na IJS" v letu 2014/15, ki bo <b><span style='color:red'>v petek, 25. marca 2016, ob 13. uri </span></b><span style='color:red'>v Veliki predavalnici Instituta »Jožef Stefan«</span> na Jamovi cesti 39 v Ljubljani. Napovednik predavanja najdete tudi na naslovu <a href="http://www.ijs.si/ijsw/Koledar_prireditev">http://www.ijs.si/ijsw/Koledar_prireditev</a>, posnetke preteklih predavanj<span style='color:blue'> </span>pa na <a href="http://videolectures.net/kolokviji_ijs">http://videolectures.net/kolokviji_ijs</a>. <o:p></o:p></p><p class=MsoNormal style='margin-bottom:12.0pt'>~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~<o:p></o:p></p><p class=MsoNormal align=center style='text-align:center'><b><i><o:p> </o:p></i></b></p><p class=MsoNormal align=center style='text-align:center'><b><i><o:p> </o:p></i></b></p><p class=MsoNormal align=center style='text-align:center'><b><span style='font-size:14.0pt'>prof. dr. Borut Štrukelj<o:p></o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><i>Institut Jožef Stefan<o:p></o:p></i></p><p class=MsoNormal align=center style='text-align:center'><b><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><b><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='mso-margin-top-alt:auto;margin-bottom:12.0pt;text-align:center'><b><span style='font-size:14.0pt'>Rekombinantni probiotiki – alternativna biološka zdravila z vnosom učinkovin v prebavila <o:p></o:p></span></b></p><p class=MsoNormal align=center style='mso-margin-top-alt:auto;margin-bottom:12.0pt;text-align:center'><b><span style='font-size:14.0pt'><o:p> </o:p></span></b></p><p class=MsoNormal style='text-align:justify'><span style='font-family:"Cambria","serif";mso-fareast-language:EN-US'>Biološka zdravila predstavljajo v zadnjih tridesetih letih velik medicinsko-tehnološki preboj v tarčnem zdravljenju različnih obolenj. Izjemne uspehe izkazujejo monoklonska protitelesa, ki predstavljajo največjo podskupino bioloških zdravil. V razvoju so trenutno že različne strukturne izpeljave monoklonskih protiteles tretje generacije. Skoraj vsa so namenjena sistemskemu vnosu ne glede na mesto delovanja v organizmu. Največ protiteles je narejenih proti rakavim obolenjem in kroničnim vnetnim boleznim. Z namenom razviti alternativna biološka zdravila, ki bi delovala lokalno v prebavilih, smo pripravili sistem z uporabo mlečnokislinskih bakterij. Pri tem smo izkoristili možnost izražanja rekombinantnih proteinov, ki delujejo kot biološka zdravila, na površini mlečnokislinskih bakterij, ki so nosilci biološke zdravilne učinkovine. Tako smo razvili sistem za inhibicijo delovanja TNFalfa, ki je en od poglavitnih vzrokov poslabšanja stanja pri ulceroznem kolitisu in Crohnovi bolezni. Na osnovi eksperimentalnih rezultatov je bil skupini podeljen tudi patent v Združenih državah Amerike. V predavanju bomo prikazali pot razvoja takega sistema in možnosti uporabe v farmaciji, medicini in biotehnologiji.<o:p></o:p></span></p><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt'>Predavanje bo v slovenščini.<o:p></o:p></p><p class=MsoNormal align=center style='mso-margin-top-alt:auto;margin-bottom:12.0pt;text-align:center'><b><span style='color:red'>Lepo vabljeni!</span></b><o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p></div></body></html>