Dnevi Jožefa Stefana, DANES ob 13:00, področje BIOZNANOSTI, prof. dr. Jonas Ries

[Martin Klanjsek]

Vabimo vas na 1. znanstveno predavanje v okviru letošnjih Dnevov Jožefa Stefana, in sicer s področja bioznanosti, ki bo danes, 23. marca 2026, ob 13:00 v Veliki predavalnici Instituta »Jožef Stefan« na Jamovi cesti 39 v Ljubljani. Predavanje bo v angleščini. Na voljo bodo kava, pijača in prigrizki.

 

 

Mikroskopija z visoko ločljivostjo za dinamično strukturno celično biologijo

 

prof. dr. Jonas Ries

Univerza na Dunaju, Dunaj, Avstrija

 

 

Optična mikroskopija visoke ločljivosti idealno dopolnjuje elektronsko mikroskopijo pri preučevanju strukture in dinamike proteinov v celicah. Visok kontrast fluorescenčnih označevalcev omogoča analizo posameznih struktur v različnih konformacijskih stanjih brez potrebe po povprečenju, hkrati pa mikroskopija visoke ločljivosti v živih celicah omogoča neposredno spremljanje dinamičnih procesov. V predavanju bom predstavil moč mikroskopije visoke ločljivosti na dveh primerih iz našega laboratorija. Najprej bom pokazal, kako nam je mikroskopija lokalizacije posameznih molekul omogočila razumevanje strukturne organizacije in dinamike kompleksnega mehanizma, ki poganja endocitozo, temeljni celični proces sprejema molekul. Nato bom predstavil, kako z metodo MINFLUX merimo konformacijske spremembe proteinov v živih celicah.

 

O predavatelju: Jonas Ries je redni profesor napredne mikroskopije in celične dinamike na Max Perutz Labs ter vodja Oddelka za strukturno in računsko biologijo Univerze na Dunaju. Je prejemnik prestižnega projekta ERC Consolidator, nagrade Fluorescence Young Investigator Award in nagrade Frontiers of Science Award. Vodil je več mednarodnih projektov, med drugim HFSP, CZI in Horizon Europe.

 

 

Napovednik predavanja in posnetke preteklih predavanj najdete na spletni strani »Kolokvijev na IJS«  <https://kolokviji.ijs.si/> https://kolokviji.ijs.si/, posnetke pa tudi posebej na  <https://video.arnes.si/?q=Kolokviji_IJS> https://video.arnes.si/?q=Kolokviji_IJS (zadnje štiri sezone) in  <http://videolectures.net/kolokviji_ijs> http://videolectures.net/kolokviji_ijs (starejši).

 

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We invite you to the 1st scientific lecture as part of this year's Jožef Stefan Days, dedicated to the field of biosciences. The lecture will take place today, 23 March 2026, at 1:00 PM in the main lecture hall of the Jožef Stefan Institute, Jamova cesta 39 in Ljubljana. The lecture will be held in English. Coffee, drinks, and snacks will be provided.

 

 

Super-resolution microscopy for dynamic structural cell biology 

 

Prof. Dr. Jonas Ries

University of Vienna, Vienna, Austria

 

 

Optical superresolution microscopy ideally complements electron microscopy for studying protein structure and dynamics in cells. The high contrast of the fluorescence label allows investigating individual structures in various conformational states without averaging, and live cell superresolution microscopy can directly probe dynamics. I will showcase the power of super-resolution microscopy by discussing two projects from the lab. First, I will show how single-molecule localization microscopy allowed us to understand the structural organization and dynamics of the complex machinery that drives endocytosis, an essential cellular process for the uptake of molecules. Second, I will show how we use MINFLUX to measure conformational changes of proteins in the living cell.

 

About the lecturer: Jonas Ries is a full professor of advanced microscopy and cellular dynamics at the Max Perutz Labs and head of the Department of Structural and Computational Biology at the University of Vienna. He is the recipient of the prestigious ERC Consolidator Grant, the Fluorescence Young Investigator Award, and the Frontiers of Science Award. He has led several international projects, including HFSP, CZI, and Horizon Europe.

 

 

The lecture trailer and recordings of past lectures can be found on the website of »JSI colloquia«  <https://kolokviji.ijs.si/> https://kolokviji.ijs.si/, and recordings specifically at  <https://video.arnes.si/en/?q=Kolokviji_IJS> https://video.arnes.si/en/?q=Kolokviji_IJS (last four seasons) and  <http://videolectures.net/kolokviji_ijs> http://videolectures.net/kolokviji_ijs (older).

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