IJS KOLOKVIJ, torek, 28. september 2010, prof. Majumder

[Andreja Berglez]

Vabim vas na 2. predavanje iz sklopa "Kolokviji na IJS" v letu 2010/11, ki bo izjemoma  v torek, 28. septembra 2010, ob 13:00 uri v Kolarjevi predavalnici Instituta »Jožef Stefan« na Jamovi cesti 39 v Ljubljani. Napovednik predavanja najdete tudi na naslovu http://www.ijs.si/ijsw/Koledar_prireditev, posnetke preteklih predavanj pa na http://videolectures.net/kolokviji_ijs. 

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

Prof. Rinku Majumder

Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, ZDA

 

 

Nove učinkovine, ki izboljšujejo sedanje preizkuse strjevanja krvi

 

 

Strjevanje krvi je fiziološki proces, pri katerem telo ščiti integriteto žil. Klinični preizkusi strjevanja krvi se redno izvajajo pri ugotavljanju motenj pri strjevanju krvi, kot sta hemofilija A in B, vendar so ti preizkusi (testi) sedaj  omejeni zaradi motenj, ki so v krvi pri nekaterih bolnikih. Treba je bilo razviti analizo strjevanja krvi, ki je ponovljiva, zanesljiva in uporabna pri bolnikih s sistemskim lupusom, pri katerih so navzoča protitelesa (lupusni antikoagulanti). Na podlagi več desetletij temeljnih raziskav delovanja kompleksa protrombinaze, ki je sestavljen iz serinskih proteaz, faktorja Xa (FXa) in njegovega kofaktorja, faktorja Va (FVa), ob navzočnosti vodotopnega fosftidilserina (PS), smo razvili in začeli  študij zanimive nove spojine PS, ki vsebuje nasičene alkilne verige, sestavljene iz samo šestih ogljikov (C6PS). Z uporabo te vodotopne molekule PS nam je v določenih okoliščinah uspelo obiti omejitve, ki jih povzročajo lupusni antikoagulanti. Za to novo učinkovino smo že pridobili ameriški patent. Uspešen razvoj tega testa strjevanja krvi bo zmanjšal število napačnih diagnoz motenj strjevanja krvi in odpravil potrebo po dragih nadaljnjih testiranjih.

 

Predavanje bo v angleščini.

Lepo vabljeni!

 

***

 




We would like to invite you to 2nd lecture of the "Kolokvij na IJS" in the school year 2010/11. The lecture will be held on Tuesday, September 28, 2010, at 1 pm at The Kolar Lecture Room, Jamova 39, Ljubljana. The abstract of the lecture can be found on website:  <http://www.ijs.si/ijsw/Koledar_prireditev> http://www.ijs.si/ijsw/Koledar_prireditev, the previous recorded lectures can be found on website:  <http://videolectures.net/kolokviji_ijs> http://videolectures.net/kolokviji_ijs. 

********************************************

Rinku Majumder

Department of Biochemistry & Biophysics, University of North Carolina at Chapel Hill, USA

 

Novel reagents to bypass limitations of existing clotting assays 

 

Blood clotting is the mean by which the body protects the integrity of blood vessels. Clinical tests, or clotting assays, are regularly performed to characterize bleeding disorders such as hemophilia A and B but are currently limited due to interferences present in the blood of some patients. There is a pressing need to develop a coagulation assay that is reproducible, reliable and that can be used for patients containing Lupus agents. Based on several decades of basic research in the regulation of  the prothrombinase complex, which consists of a serine protease, factor Xa (FXa), and a protein cofactor, factor Va (FVa) by water soluble Phosphatidyl Serine (PS), we have developed and started to study an exciting novel  PS compound containing saturated diacyl chains of only six carbons (C6PS). Using this soluble PS molecule, we have been able under ceratin circumstances to bypass the limitations caused by lupus anticoagulants and we have already obtained an US Patent for this novel reagent. Successful development of this assay will decrease misdiagnoses of bleeding disorders and will remove the need for expensive subsequent testing.

 

 

We look forward to meeting you at the “Kolokvij na IJS”!

 

 

-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://mailman.ijs.si/pipermail/kolokvij-ijs/attachments/20100924/836ab4af/attachment.html>