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<div class="WordSection1">
<p class="MsoTitle" align="left" style="margin:0cm;margin-bottom:.0001pt;text-align:left">
<span lang="EN-US" style="font-size:9.0pt;font-family:"Verdana","sans-serif";color:black;font-weight:normal"><o:p> </o:p></span></p>
<p class="MsoTitle" style="margin:0cm;margin-bottom:.0001pt"><span lang="EN-US" style="font-size:20.0pt;font-family:"Verdana","sans-serif";color:black;font-weight:normal">VABILO NA PREGLOV KOLOKVIJ / INVITATION TO THE PREGL COLLOQUIUM<o:p></o:p></span></p>
<p class="MsoNormal"><b><span lang="FR" style="font-size:18.0pt;font-family:"Verdana","sans-serif""><o:p> </o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center;layout-grid-mode:char;text-autospace:none;vertical-align:baseline">
<b><span style="font-size:18.0pt;font-family:"Verdana","sans-serif"">Prof. Kensuke MIYAKE<o:p></o:p></span></b></p>
<p align="center" style="margin:0cm;margin-bottom:.0001pt;text-align:center"><b><span style="font-size:18.0pt;font-family:"Verdana","sans-serif""><o:p> </o:p></span></b></p>
<p align="center" style="margin:0cm;margin-bottom:.0001pt;text-align:center"><span style="font-family:"Verdana","sans-serif";color:black">Division of Innate Immunity, Department of Microbiology and Immunology,
</span><span lang="EN-US" style="font-family:"Verdana","sans-serif";color:black">Laboratory of Innate Immunity, Center for Experimental Medicine and Systems Biology
<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center;layout-grid-mode:char;text-autospace:none;vertical-align:baseline">
<span lang="EN-US" style="font-size:12.0pt;font-family:"Verdana","sans-serif";color:black">The Institute of Medical Science, The University of Tokyo;
</span><span style="font-family:"Verdana","sans-serif""><a href="mailto:kmiyake@ims.u-tokyo.ac.jp"><span lang="EN-US" style="font-size:12.0pt">kmiyake@ims.u-tokyo.ac.jp</span></a></span><span class="MsoHyperlink"><o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span style="font-size:8.0pt;mso-fareast-language:SL"><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center;line-height:150%"><b><span lang="EN-US" style="font-size:8.0pt;line-height:150%;font-family:"Verdana","sans-serif""><o:p> </o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center;line-height:150%"><b><span lang="EN-US" style="font-size:16.0pt;line-height:150%;font-family:"Verdana","sans-serif"">Sreda / Wednesday 24. 06. 2015, ob / at 13:00
<o:p></o:p></span></b></p>
<h6 style="mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:6.0pt;margin-left:0cm">
<b><span lang="EN-US" style="font-size:11.0pt;font-family:"Verdana","sans-serif"">Velika predavalnica Kemijskega inštituta / Lecture Hall at the National Institute of Chemistry; Hajdrihova 19, Ljubljana</span></b><b><span lang="EN-US" style="font-size:12.0pt;font-family:"Verdana","sans-serif"">
<o:p></o:p></span></b></h6>
<p class="MsoNormal" style="mso-margin-top-alt:6.0pt;margin-right:0cm;margin-bottom:6.0pt;margin-left:0cm;text-align:justify">
<b><span lang="EN-US" style="font-size:9.0pt;font-family:"Verdana","sans-serif";color:#993366"><o:p> </o:p></span></b></p>
<p class="EndNoteBibliography" style="margin-bottom:0cm;margin-bottom:.0001pt"><span lang="EN-US" style="font-size:9.0pt;font-family:"Verdana","sans-serif";color:#660066"><o:p> </o:p></span></p>
<h1 align="center" style="text-align:center"><span lang="EN-GB" style="font-size:20.0pt;font-family:"Verdana","sans-serif";color:#660066">Nucleic Acid Recognition by Toll-like receptors<o:p></o:p></span></h1>
<p class="MsoNormal"><span lang="EN-GB"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB"><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center;layout-grid-mode:char">
<span lang="FR" style="font-size:12.0pt;color:black;mso-fareast-language:JA"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify;layout-grid-mode:char"><span lang="EN-US" style="font-size:12.0pt;font-family:"Verdana","sans-serif";color:black">The Toll family of receptors has critical roles in microbial recognition and activation of defense
responses. Nucleic acid (NA) is a major Toll-like receptor (TLR) ligand. TLR3, 7/8, and 9 reside in intracellular organelle and sense double strand (ds) RNA, single strand (ss) RNA, and ssDNA respectively. NA-sensing TLRs respond to not only microbial but
also self-derived NA, and have been implicated in a variety of autoimmune diseases. To understand a mechanism behind the pathogenic role of NA-sensing TLRs in autoimmune diseases, it is important to understand how NA is sensed by TLRs. We here focus on recent
progresses on the structural bases of NA recognition by TLR8 and TLR9 and on the role of NA degradation in NA-sensing by TLRs.</span><span lang="EN-US" style="font-size:12.0pt;font-family:"Verdana","sans-serif";color:black;mso-fareast-language:JA"><o:p></o:p></span></p>
<p class="MsoNormal" style="line-height:150%;layout-grid-mode:char"><span lang="EN-US" style="font-size:12.0pt;line-height:150%;font-family:"Verdana","sans-serif";color:black;mso-fareast-language:JA"><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center;line-height:150%"><b><span lang="EN-US" style="font-size:14.0pt;line-height:150%;font-family:"Verdana","sans-serif"">Vljudno vabljeni! / Kindly invited!<o:p></o:p></span></b></p>
<p class="MsoNormal"><span lang="FR"><o:p> </o:p></span></p>
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