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<span style="font-size:10.5pt;color:blue">Spo</span><span style="font-size:10.5pt;color:#1F497D">š</span><span style="font-size:10.5pt;color:blue">tovani,</span><span style="font-size:10.5pt"><o:p></o:p></span></p>
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<span style="font-size:10.5pt"><o:p> </o:p></span></p>
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<span style="font-size:10.5pt;color:blue">Vabimo vas na Preglov kolokvij, v <b>ponedeljek</b>, 26. maja ob
<b>10.30</b>. </span><span style="font-size:10.5pt"><o:p></o:p></span></p>
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<span style="font-size:10.5pt;color:blue">Velika predavalnica Kemijskega instituta.</span><span style="font-size:10.5pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:normal">
<span style="font-size:10.5pt"><o:p> </o:p></span></p>
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<span style="font-size:10.5pt;color:blue">Gostja: prof. Andrea Markelz, </span><span style="font-size:12.0pt;color:blue">Department of Physics, University at Buffalo, SUNY, 239 Fronczak Hall, Buffalo, New York, 14260, ZDA</span><span style="font-size:12.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:normal">
<span style="font-size:10.5pt"><o:p> </o:p></span></p>
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<span style="font-size:10.5pt;color:blue">Naslov: </span><span class="apple-style-span"><b><span style="font-size:12.0pt;color:blue;text-transform:uppercase">MEASUREMENTS OF LONG-RANGE PROTEIN MOTIONS<o:p></o:p></span></b></span></p>
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<span class="apple-style-span"><b><span style="font-size:12.0pt;color:blue;text-transform:uppercase"><o:p> </o:p></span></b></span></p>
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<span style="font-size:10.5pt;color:blue">Več informacij spodaj in v priponki.</span><span style="font-size:10.5pt"><o:p></o:p></span></p>
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<span style="font-size:10.5pt;color:blue">Lep dan želim,<o:p></o:p></span></p>
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<span style="font-size:10.5pt;color:blue"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt;line-height:normal">
<span style="font-size:10.5pt;color:blue">Brigita Pirc<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;line-height:115%;font-family:"Calibri","sans-serif";color:#1F497D">***<o:p></o:p></span></p>
<p class="MsoTitle" style="margin:0cm;margin-bottom:.0001pt"><span lang="EN-US" style="font-family:"Verdana","sans-serif";color:black;font-weight:normal">VABILO NA PREGLOV KOLOKVIJ / INVITATION TO THE PREGL COLLOQUIUM<o:p></o:p></span></p>
<p class="MsoNormal"><b><span lang="EN-US" style="font-size:12.0pt;line-height:115%;font-family:"Verdana","sans-serif""><o:p> </o:p></span></b></p>
<p align="center" style="margin:0cm;margin-bottom:.0001pt;text-align:center"><b><span lang="EN-US" style="font-size:18.0pt;font-family:"Verdana","sans-serif";mso-fareast-language:SL">Prof. Dr. Andrea Markelz<o:p></o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-US" style="font-size:12.0pt;line-height:115%;font-family:"Verdana","sans-serif"">Department of Physics, University at Buffalo, SUNY, 239 Fronczak Hall, Buffalo, New York, 14260, USA<span style="color:black">,
e-mail: </span></span><span style="font-size:12.0pt;line-height:115%;font-family:"Verdana","sans-serif""><a href="mailto:amarkelz@buffalo.edu">amarkelz@buffalo.edu</a>
</span><span lang="EN-US" style="font-size:12.0pt;line-height:115%;font-family:"Verdana","sans-serif""><o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center;line-height:150%"><b><span lang="EN-US" style="font-size:14.0pt;line-height:150%;font-family:"Verdana","sans-serif""><o:p> </o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center;line-height:150%"><b><span lang="EN-US" style="font-size:14.0pt;line-height:150%;font-family:"Verdana","sans-serif"">Ponedeljek, Monday, 26. 5. 2014, ob / at 10:30</span></b><b><span lang="EN-US" style="font-size:14.0pt;line-height:150%;font-family:"Verdana","sans-serif";mso-fareast-language:FR"><o:p></o:p></span></b></p>
<h6 style="mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:6.0pt;margin-left:0cm">
<b><span lang="EN-US" style="font-size:11.0pt;font-family:"Verdana","sans-serif"">Velika predavalnica Kemijskega inštituta / Lecture Hall at the National Institute of Chemistry; Hajdrihova 19, Ljubljana</span></b><b><span lang="EN-US" style="font-size:12.0pt;font-family:"Verdana","sans-serif"">
<o:p></o:p></span></b></h6>
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<b><span lang="EN-US" style="font-size:9.0pt;line-height:115%;font-family:"Verdana","sans-serif";color:#993366"><o:p> </o:p></span></b></p>
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<b><span style="font-size:18.0pt;line-height:115%;font-family:"Verdana","sans-serif";color:#8C1794;text-transform:uppercase">MEASUREMENTS OF LONG-RANGE PROTEIN MOTIONS</span></b><b><span lang="EN-US" style="font-size:18.0pt;line-height:115%;font-family:"Verdana","sans-serif";color:#8C1794"><o:p></o:p></span></b></p>
<p class="EndNoteBibliography" style="margin-bottom:0cm;margin-bottom:.0001pt"><span lang="EN-US" style="font-size:8.0pt;font-family:"Verdana","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify;mso-line-height-alt:5.0pt"><span lang="EN-US" style="font-size:12.0pt;font-family:"Helvetica","sans-serif"">Allosteric control of enzymatic reactions continues to be a field of interest as an avenue of species
specific drug design that targets critical pathway enzymes. A natural question is why the remote regions of protein are correlated to the substrate site? A particular compelling mechanism is collective vibrational motions of the protein, which involved correlated
motion both at the remote site and the binding site. If these long range motions specifically access binding configurations then allosteric control is a natural consequence of perturbing the long range motion at the remote site. Direct measurements of collective
modes previously involved either X-ray or neutron scattering, limiting the measurements undertaken. Here we discuss measurements of the frequency and structural dependence of collective modes using crystal anisotropy terahertz microscopy (CATM) [1]. This
new technique removes the strong isotropic relaxational background from librational motions of the solvent and surface side chains. In addition, anisotropy measurements have the potential to aid in mode identification, as we found previously for molecular
crystals. For large systems such as proteins we need to consider general groups of motions. In particular the anisotropy indicates the general structural dependence of accessible motions. We consider methods to distil the dense density of states and isotropic
spectrum to spectral regions specifically associated with motions that are spectrally relevant.</span><span lang="EN-US" style="font-family:"Helvetica","sans-serif";mso-fareast-language:EN-US"><o:p></o:p></span></p>
<p class="EndNoteBibliography" style="margin-bottom:0cm;margin-bottom:.0001pt"><a name="_ENREF_3"><span lang="EN-US" style="font-size:10.0pt;font-family:"Helvetica","sans-serif"">[1] Acbas, G., K.A. Niessen, E.H. Snell, and A.G. Markelz,
<i>Optical measurements of long-range protein vibrations.</i> Nat Commun, 2014. <b>
5</b>.</span></a><span lang="EN-US" style="font-size:10.0pt;font-family:"Helvetica","sans-serif""><o:p></o:p></span></p>
<p class="EndNoteBibliography" style="margin-bottom:0cm;margin-bottom:.0001pt"><span lang="EN-US" style="font-size:8.0pt;font-family:"Verdana","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify;text-autospace:none"><span lang="EN-US" style="font-size:8.0pt;line-height:115%;font-family:"Verdana","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center;line-height:150%"><b><span lang="EN-US" style="font-size:14.0pt;line-height:150%;font-family:"Verdana","sans-serif"">Vljudno vabljeni! / Kindly invited!<o:p></o:p></span></b></p>
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