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<p class="MsoTitle" style="margin:0cm;margin-bottom:.0001pt"><span lang="EN-US" style="font-family:"Verdana","sans-serif";color:black;font-weight:normal">VABILO NA PREGLOV KOLOKVIJ / INVITATION TO THE PREGL COLLOQUIUM<o:p></o:p></span></p>
<p class="MsoNormal"><b><span lang="EN-US" style="font-size:12.0pt;font-family:"Verdana","sans-serif""><o:p> </o:p></span></b></p>
<p class="MsoNormal"><b><span lang="EN-US" style="font-size:12.0pt;font-family:"Verdana","sans-serif""><o:p> </o:p></span></b></p>
<p align="center" style="margin:0cm;margin-bottom:.0001pt;text-align:center"><b><span lang="EN-US" style="font-size:18.0pt;font-family:"Verdana","sans-serif";mso-fareast-language:SL">Prof. Bert de Groot,
</span></b><span lang="EN-US" style="font-size:18.0pt;font-family:"Verdana","sans-serif";mso-fareast-language:SL">Ph.D.<b><o:p></o:p></b></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-US" style="font-size:18.0pt;font-family:"Verdana","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-US" style="font-size:12.0pt;font-family:"Verdana","sans-serif";color:black">Max Planck Institute for biophysical chemistry Göttingen, Germany,
<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-US" style="font-size:12.0pt;font-family:"Verdana","sans-serif";color:black">e-mail:
</span><span lang="EN-US" style="font-size:12.0pt;font-family:"Verdana","sans-serif";mso-fareast-language:EN-US"><a href="mailto:bgroot@gwdg.de">bgroot@gwdg.de</a>
</span><span lang="EN-US" style="font-size:12.0pt;font-family:"Verdana","sans-serif";mso-fareast-language:SL"><o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-US" style="font-size:8.0pt;font-family:"Arial","sans-serif";mso-fareast-language:SL"><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center"><span lang="EN-US" style="font-size:8.0pt;font-family:"Verdana","sans-serif";mso-fareast-language:SL"><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center;line-height:150%"><b><span lang="EN-US" style="font-size:14.0pt;line-height:150%;font-family:"Verdana","sans-serif"">Èetrtek, Thursday, 8. 5. 2014, ob / at 13:00<o:p></o:p></span></b></p>
<h6 style="mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:6.0pt;margin-left:0cm">
<b><span lang="EN-US" style="font-size:11.0pt;font-family:"Verdana","sans-serif"">Velika predavalnica Kemijskega inıtituta / Lecture Hall at the National Institute of Chemistry; Hajdrihova 19, Ljubljana</span></b><b><span lang="EN-US" style="font-size:12.0pt;font-family:"Verdana","sans-serif"">
<o:p></o:p></span></b></h6>
<p class="MsoNormal" style="mso-margin-top-alt:6.0pt;margin-right:0cm;margin-bottom:6.0pt;margin-left:0cm;text-align:justify">
<b><span lang="EN-US" style="font-size:9.0pt;font-family:"Verdana","sans-serif";color:#993366"><o:p> </o:p></span></b></p>
<p class="MsoNormal" align="center" style="text-align:center;text-autospace:none">
<b><span lang="EN-US" style="font-size:18.0pt;font-family:"Verdana","sans-serif";color:#941B54">Molecular dynamics of inhibition, permeation and recognition<o:p></o:p></span></b></p>
<p class="MsoNormal" style="text-align:justify;text-autospace:none"><span lang="EN-US" style="font-size:11.0pt;font-family:"Verdana","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify;text-autospace:none"><span lang="EN-US" style="font-family:"Verdana","sans-serif";color:black;mso-fareast-language:EN-US">Can we design specific membrane channel inhibitors? What is the antimicrobial mechanism
of the human antibiotic dermcidin? What are the molecular determinants of channel permeation and gating? What is the molecular basis of protein-protein recognition, and can we alter protein binding affinity by computational design? These are some of the questions
that are addressed at the atomic level by molecular dynamics simulations.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify;text-autospace:none"><span lang="EN-US" style="font-size:11.0pt;font-family:"Verdana","sans-serif";color:black;mso-fareast-language:EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center;text-autospace:none">
<span style="mso-fareast-language:SL"><img border="0" width="110" height="97" id="Picture_x0020_2" src="cid:image001.jpg@01CF5F04.4DD81B30" alt="Description: A description..."></span><span lang="EN-US" style="font-size:11.0pt;font-family:"Verdana","sans-serif";color:black;mso-fareast-language:EN-US"><o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify;text-autospace:none"><span lang="EN-US" style="font-size:11.0pt;font-family:"Verdana","sans-serif";color:black;mso-fareast-language:EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span lang="FR" style="font-size:8.0pt;font-family:"Verdana","sans-serif"">[1] Sören J. Wacker, Camilo Aponte-Santamaria, Per Kjellbom, Soren Nielsen, Bert L. de Groot, Michael Rützler.
<i>The identification of novel, high affinity AQP9 inhibitors in an intracellular binding site.</i> Molecular Membrane Biology 30:246-260 (2013).<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span lang="FR" style="font-size:8.0pt;font-family:"Verdana","sans-serif";color:black">[2]
</span><span lang="FR" style="font-size:8.0pt;font-family:"Verdana","sans-serif"">Ulrich Zachariae, Robert Schneider, Rodolfo Briones, Zrinka Gattin, Jean-Philippe Demers, Karin Giller, Elke Maier, Markus Zweckstetter, Christian Griesinger, Stefan Becker, Roland
Benz, Bert L. de Groot, and Adam Lange. <em><span style="font-family:"Verdana","sans-serif"">Beta-barrel mobility underlies closure of the voltage-dependent anion channel.
</span></em>Structure<b>.</b> 20:1540-1549 (2012).<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span lang="FR" style="font-size:8.0pt;font-family:"Verdana","sans-serif"">[3]
<span style="color:black">Chen Song, Conrad Weichbrodt, Evgeniy S. Salnikov, Marek Dynowski, Björn O. Forsberg, Burkhard Bechinger, Claudia Steinem, Bert L. de Groot, Ulrich Zachariae, and Kornelius Zeth.<em><span style="font-family:"Verdana","sans-serif"">Crystal
structure and functional mechanism of a human antimicrobial membrane channel. </span>
</em>Proc. Nat. Acad. Sci. 110: 4586-4591 (2013).<o:p></o:p></span></span></p>
<p class="MsoNormal" style="text-align:justify"><span lang="FR" style="font-size:8.0pt;font-family:"Verdana","sans-serif"">[4] Carsten Kutzner, Helmut Grubmüller, Bert L. de Groot, Ulrich Zachariae.
<em><span style="font-family:"Verdana","sans-serif"">Computational Electrophysiology: The Molecular Dynamics of Ion Channel Permeation and Selectivity in Atomistic Detail.
</span></em>Biophys. J.<b> </b>101: 809-817 (2011).<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align:justify"><span lang="FR" style="font-size:8.0pt;font-family:"Verdana","sans-serif"">[5]
<span style="color:black">Jan-Henning Peters and Bert L. de Groot. <em><span style="font-family:"Verdana","sans-serif"">Ubiquitin dynamics in complexes reveal molecular recognition mechanisms beyond induced fit and conformational selection.
</span></em>PLoS Comp. Biol.<b> </b>8: e1002704 (2012).<o:p></o:p></span></span></p>
<p class="MsoNormal" style="text-align:justify;text-autospace:none"><span lang="EN-US" style="font-size:8.0pt;font-family:"Verdana","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal" style="text-align:justify;text-autospace:none"><span lang="EN-US" style="font-size:8.0pt;font-family:"Verdana","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal" align="center" style="text-align:center;line-height:150%"><b><span lang="EN-US" style="font-size:14.0pt;line-height:150%;font-family:"Verdana","sans-serif"">Vljudno vabljeni! / Kindly invited!<o:p></o:p></span></b></p>
<p class="MsoNormal"><span lang="FR" style="font-size:11.0pt;font-family:"Calibri","sans-serif""><o:p> </o:p></span></p>
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