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</o:shapelayout></xml><![endif]--></head><body lang=SL link=blue vlink=purple><div class=WordSection1><p class=MsoNormal><i><span lang=FR style='font-size:11.0pt;font-family:"Verdana","sans-serif"'>Spoštovani !<o:p></o:p></span></i></p><p class=MsoNormal><i><span lang=FR style='font-size:11.0pt;font-family:"Verdana","sans-serif"'><o:p> </o:p></span></i></p><p class=MsoNormal><i><span lang=FR style='font-size:11.0pt;font-family:"Verdana","sans-serif"'>Še enkrat posredujem vabilo na Preglov kolokvij prihodnji četrtek, s spremembo ure iz 13:00 na <span style='background:yellow;mso-highlight:yellow'>16:00</span>.<o:p></o:p></span></i></p><p class=MsoNormal><i><span lang=FR style='font-size:11.0pt;font-family:"Verdana","sans-serif"'>Hvala za razumevanje,<o:p></o:p></span></i></p><p class=MsoNormal><i><span lang=FR style='font-family:"Verdana","sans-serif"'>Brigita<span style='color:#1F497D'> </span>Pirc<o:p></o:p></span></i></p><p class=MsoNormal><i><span lang=FR style='font-family:"Verdana","sans-serif"'>Kemijski inštitut Ljubljana<o:p></o:p></span></i></p><p class=MsoNormal><span lang=FR><o:p> </o:p></span></p><p class=MsoTitle align=left style='margin:0cm;margin-bottom:.0001pt;text-align:left'><span style='font-size:9.0pt;font-family:"Verdana","sans-serif";color:black;font-weight:normal'><o:p> </o:p></span></p><p class=MsoTitle style='margin:0cm;margin-bottom:.0001pt'><span style='font-size:18.0pt;font-family:"Verdana","sans-serif";color:black;font-weight:normal'>***<o:p></o:p></span></p><p class=MsoTitle style='margin:0cm;margin-bottom:.0001pt'><span style='font-size:18.0pt;font-family:"Verdana","sans-serif";color:black;font-weight:normal'>VABILO NA PREGLOV KOLOKVIJ / INVITATION TO THE PREGL COLLOQUIUM<o:p></o:p></span></p><p class=MsoNormal><b><span style='font-size:12.0pt;font-family:"Verdana","sans-serif"'><o:p> </o:p></span></b></p><p class=MsoNormal><b><span style='font-family:"Verdana","sans-serif";mso-fareast-language:SL'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><span lang=FR style='font-size:22.0pt;font-family:"Verdana","sans-serif"'>Dr. Jernej Ule</span><span lang=EN-US><o:p></o:p></span></p><p class=MsoNormal align=center style='text-align:center'><span lang=EN-GB style='font-size:14.0pt;font-family:"Verdana","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal align=center style='text-align:center'><span lang=EN-GB style='font-size:14.0pt;font-family:"Verdana","sans-serif"'>MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH<o:p></o:p></span></p><p class=MsoNormal align=center style='text-align:center'><b><span style='font-size:11.0pt;font-family:"Verdana","sans-serif"'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><b><span lang=EN-GB style='font-size:14.0pt;font-family:"Verdana","sans-serif";color:#993366'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><b><span lang=EN-GB style='font-size:18.0pt;font-family:"Verdana","sans-serif";color:#993366'>How can ALU elements generate new exons in human transcripts?<o:p></o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><b><span lang=EN-GB style='font-size:18.0pt;font-family:"Verdana","sans-serif";color:#993366'>/<o:p></o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><b><span lang=EN-GB style='font-size:18.0pt;font-family:"Verdana","sans-serif";color:#993366'>Kako lahko elementi ALU tvorijo nove eksone v človeških transkriptih?<o:p></o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><span lang=IT style='font-size:8.0pt;font-family:"Verdana","sans-serif";mso-fareast-language:SL'><o:p> </o:p></span></p><p class=MsoNormal align=center style='text-align:center'><span lang=IT style='font-size:8.0pt;font-family:"Verdana","sans-serif";mso-fareast-language:SL'><o:p> </o:p></span></p><p class=MsoNormal align=center style='text-align:center'><span lang=IT style='font-size:8.0pt;font-family:"Verdana","sans-serif";mso-fareast-language:SL'><o:p> </o:p></span></p><p class=MsoNormal align=center style='text-align:center;line-height:150%'><b><span style='font-size:16.0pt;line-height:150%;font-family:"Verdana","sans-serif"'>Četrtek / Thursday, 22. 12. 2011, ob / <span style='background:yellow;mso-highlight:yellow'>at 16:00</span><o:p></o:p></span></b></p><h6 style='mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:6.0pt;margin-left:0cm'><b><span lang=FR style='font-size:12.0pt;font-family:"Verdana","sans-serif"'>Velika predavalnica Kemijskega inštituta / Lecture Hall at the National Institute of Chemistry; Hajdrihova 19, Ljubljana <o:p></o:p></span></b></h6><p class=MsoNormal><span lang=EN-US style='font-size:8.0pt;font-family:"Arial","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt;text-align:justify;text-autospace:none'><span lang=FR style='font-size:11.0pt;font-family:"Verdana","sans-serif"'>Approximately a half of the human genome is composed of mobile genetic elements. These elements can copy themselves and move around in the genome. The most common of these are ALU elements (ALUs), which originated during primate evolution. ALUs that became inserted into our genes are the main source of human-specific exons. Interestingly, when inserted in the antisense orientation, ALUs contain a binding site for U2AF65, a protein that initiates splicing of exons. Using genome-wide iCLIP experiments, we found that splicing of ALUs is suppressed by heterogeneous nuclear ribonucleoprotein C (hnRNP C), which competes with U2AF65 for the same binding site. Using computational and experimental approaches, we show that mutations in ALUs can create new exons by decreasing the capacity of hnRNP C to compete with U2AF65. I will present experiments where we demonstrate the importance of this phenomenon for disease and evolution.<o:p></o:p></span></p><p class=MsoNormal><span lang=FR><o:p> </o:p></span></p><p class=MsoNormal align=center style='text-align:center;line-height:150%'><span lang=EN-US style='font-size:11.0pt;line-height:150%;font-family:"Verdana","sans-serif";mso-fareast-language:SL'>Vljudno vabljeni! / Kindly invited!<o:p></o:p></span></p><p class=MsoNormal align=center style='text-align:center;line-height:150%'><span lang=EN-US style='font-size:11.0pt;line-height:150%;font-family:"Verdana","sans-serif";mso-fareast-language:SL'>***<o:p></o:p></span></p><p class=MsoNormal><span lang=FR style='font-size:11.0pt;font-family:"Calibri","sans-serif"'><o:p> </o:p></span></p></div></body></html>