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</o:shapelayout></xml><![endif]--></head><body lang=SL link=blue vlink=purple><div class=WordSection1><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><span lang=FR style='font-family:"Verdana","sans-serif"'><o:p> </o:p></span></p><p class=MsoTitle style='margin:0cm;margin-bottom:.0001pt'><span style='font-size:18.0pt;font-family:"Verdana","sans-serif";color:black;font-weight:normal'>VABILO NA PREGLOV KOLOKVIJ /<o:p></o:p></span></p><p class=MsoTitle style='margin:0cm;margin-bottom:.0001pt'><span style='font-size:18.0pt;font-family:"Verdana","sans-serif";color:black;font-weight:normal'>INVITATION TO THE PREGL COLLOQUIUM<o:p></o:p></span></p><p class=MsoNormal><b><span lang=EN-GB style='font-size:20.0pt;font-family:"Verdana","sans-serif"'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><b><span lang=EN-GB style='font-size:18.0pt;font-family:"Verdana","sans-serif"'>Prof. Robert Konrat<o:p></o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><b><i><span lang=EN-GB style='font-size:16.0pt;font-family:"Verdana","sans-serif";mso-fareast-language:EN-US'>Department of Structural and Computational Biology, Max F. Perutz Laboratories, University of Vienna<o:p></o:p></span></i></b></p><p class=MsoNormal align=center style='text-align:center'><b><span style='font-size:8.0pt;font-family:"Verdana","sans-serif"'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><b><span style='font-size:18.0pt;font-family:"Verdana","sans-serif"'>Četrtek/Thursday, 10. 11. 2011,<o:p></o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><b><span style='font-size:18.0pt;font-family:"Verdana","sans-serif"'>ob/at 13<sup>h<o:p></o:p></sup></span></b></p><p class=MsoNormal align=center style='text-align:center'><b><span style='font-size:18.0pt;font-family:"Verdana","sans-serif"'><o:p> </o:p></span></b></p><h6 style='margin:0cm;margin-bottom:.0001pt'><b><span lang=EN-GB style='font-size:14.0pt;font-family:"Verdana","sans-serif"'>Velika predavalnica na Kemijskem inštitutu/<o:p></o:p></span></b></h6><h6 style='margin:0cm;margin-bottom:.0001pt'><b><span lang=EN-GB style='font-size:14.0pt;font-family:"Verdana","sans-serif"'>Lecture Hall at the National Institute of Chemistry<o:p></o:p></span></b></h6><p class=MsoNormal align=center style='text-align:center'><b><span style='font-size:14.0pt;font-family:"Verdana","sans-serif"'>Hajdrihova 19, Ljubljana<i> </i></span></b><b><i><span lang=FR style='font-size:14.0pt;font-family:"Verdana","sans-serif"'><o:p></o:p></span></i></b></p><p class=MsoNormal align=center style='mso-margin-top-alt:0cm;margin-right:12.6pt;margin-bottom:0cm;margin-left:18.0pt;margin-bottom:.0001pt;text-align:center'><b><span lang=EN-GB style='font-size:14.0pt;font-family:"Verdana","sans-serif";color:#993366'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><b><span lang=EN-GB style='font-size:18.0pt;font-family:"Verdana","sans-serif";color:#993366;mso-fareast-language:SL'>Conceptualization in Chemistry and Molecular Biology <o:p></o:p></span></b></p><p class=MsoNormal align=center style='margin-bottom:18.0pt;text-align:center'><b><span lang=EN-GB style='font-size:18.0pt;font-family:"Verdana","sans-serif";color:#993366;mso-fareast-language:SL'>A Prerequisite for Methodological Advances and Scientific Progress<o:p></o:p></span></b></p><p class=MsoNormal style='text-align:justify;text-indent:35.4pt'><span lang=EN-GB style='font-size:9.5pt;font-family:"Verdana","sans-serif";mso-fareast-language:DE'>Conceptualization precedes abstract reasoning and is thus constitutive for natural science research. Theoretical concepts as much as methodological developments determine and even define the framework in which scientific investigations are performed as well as the questions possibly being addressed. Scientific terminology (or jargon) therefore introduces a scientific bias that is often ignored. Taking into account this interdependence is, however, indispensable for deeper understanding of science in general and for scientific developments to continue to occur. To illustrate how scientific jargon pre-defines the scientific topics I will discuss the paradigmatic structure-function concept that protein functionality relies on the existence of a stably folded protein scaffold. Although it has already been put in question and it is now acknowledged that an increasing number of proteins are lacking stably folded tertiary structures (Dyson & Wright, 2005) and that this intrinsic flexibility has significant impact on biological functionality, an appropriate scientific conceptualization is still missing. The popular dichotomic partitioning of proteins into ordered and disordered specimens does not adequately grasp the dynamic conformational ensembles of fluctuating polypeptides and their relevance for biological function. In the lecture I will try demonstrate that the binary order-disorder conceptual framework can be overcome by the recently introduced meta-structure approach (Konrat, 2009) and by adapting concepts from theoretical physics a higher level of description is obtained in which intrinsically disordered proteins reveal many more of their intricate physico-chemical properties. The theoretical predictions are validated with a diverse set of experimental data obtained on several proteins implicated in cell cycle regulation, tumor growth and metastasis.<o:p></o:p></span></p><p class=MsoNormal style='text-align:justify;text-indent:35.4pt'><span lang=EN-GB style='font-size:9.5pt;font-family:"Verdana","sans-serif";mso-fareast-language:DE'>Methods development is another cornerstone of natural science. In the past major scientific breakthroughs were triggered or initiated through the availability of novel scientific techniques. Amongst others Fritz Pregl was an eminent figure in the long series of methodological advances in chemistry and a shining example for how technology drives science. As an illustration (also how proper concepts and methods development coincide) I will discuss some of our recent NMR developments in protein chemistry. Although NMR spectroscopy was introduced as an analytical technique to determine the structures of small molecules, recent past has witnessed considerable improvements of the methodology and it therefore continues to play an important role not only in chemistry but life science research in general.<o:p></o:p></span></p><p class=MsoNormal style='text-align:justify;text-indent:35.4pt'><span lang=EN-GB style='font-size:9.5pt;font-family:"Verdana","sans-serif";mso-fareast-language:DE'><o:p> </o:p></span></p><p class=MsoNormal align=center style='text-align:center'><span lang=FR style='font-size:12.0pt;font-family:"Verdana","sans-serif"'>Vljudno vabljeni! / Kindly invited!<o:p></o:p></span></p><p class=MsoNormal align=center style='text-align:center'><span lang=FR style='font-size:12.0pt;font-family:"Verdana","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal align=center style='text-align:center'><span lang=FR style='font-size:12.0pt;font-family:"Verdana","sans-serif";color:#1F497D'>Information:primoz.sket@ki.si <o:p></o:p></span></p><p class=MsoNormal><span lang=FR style='font-size:12.0pt;font-family:"Verdana","sans-serif"'> <o:p></o:p></span></p><p class=MsoNormal><span lang=FR><o:p> </o:p></span></p></div></body></html>