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</o:shapelayout></xml><![endif]--></head><body lang=SL link=blue vlink=purple><div class=WordSection1><p class=MsoNormal><a name="OLE_LINK2"></a><a name="OLE_LINK1"><span style='font-size:10.0pt'><o:p> </o:p></span></a></p><p class=MsoTitle align=left style='margin:0cm;margin-bottom:.0001pt;text-align:left'><span style='font-size:9.0pt;font-family:"Verdana","sans-serif";color:black;font-weight:normal'><o:p> </o:p></span></p><p class=MsoTitle style='margin:0cm;margin-bottom:.0001pt'><span style='font-size:18.0pt;font-family:"Verdana","sans-serif";color:black;font-weight:normal'>***<o:p></o:p></span></p><p class=MsoTitle style='margin:0cm;margin-bottom:.0001pt'><span style='font-size:18.0pt;font-family:"Verdana","sans-serif";color:black;font-weight:normal'>VABILO NA PREGLOV KOLOKVIJ / INVITATION TO THE PREGL COLLOQUIUM<o:p></o:p></span></p><p class=MsoNormal><b><span style='font-size:12.0pt;font-family:"Verdana","sans-serif"'><o:p> </o:p></span></b></p><p class=MsoNormal><b><span style='font-size:12.0pt;font-family:"Verdana","sans-serif"'><o:p> </o:p></span></b></p><pre style='text-align:center'><b><span style='font-size:18.0pt;font-family:"Verdana","sans-serif";mso-fareast-language:SL'>Prof. dr. Henrike Heise<o:p></o:p></span></b></pre><p class=Default><o:p> </o:p></p><p class=MsoNormal align=center style='text-align:center;line-height:150%'><span style='font-family:"Verdana","sans-serif"'>Heinrich-Heine-Universität Düsseldorf, Universitätsstraße 1, <o:p></o:p></span></p><p class=MsoNormal align=center style='text-align:center;line-height:150%'><span style='font-family:"Verdana","sans-serif"'>40225 Düsseldorf ICS-6, Forschungszentrum Jülich, 52425 Jülich<o:p></o:p></span></p><p class=MsoNormal align=center style='text-align:center'><b><span style='font-family:"Verdana","sans-serif"'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='text-align:center'><span lang=IT style='font-size:8.0pt;font-family:"Arial","sans-serif";mso-fareast-language:SL'><o:p> </o:p></span></p><p class=MsoNormal align=center style='text-align:center'><span lang=IT style='font-size:8.0pt;font-family:"Verdana","sans-serif";mso-fareast-language:SL'><o:p> </o:p></span></p><p class=MsoNormal align=center style='text-align:center;line-height:150%'><b><span style='font-size:16.0pt;line-height:150%;font-family:"Verdana","sans-serif"'>Četrtek / Thursday, 12. 05. 2011, ob / at 13:00</span></b><b><span style='font-size:16.0pt;line-height:150%;font-family:"Verdana","sans-serif";mso-fareast-language:FR'><o:p></o:p></span></b></p><h6 style='mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:6.0pt;margin-left:0cm'><b><span lang=FR style='font-size:12.0pt;font-family:"Verdana","sans-serif"'>Velika predavalnica Kemijskega inštituta / Lecture Hall at the <o:p></o:p></span></b></h6><h6 style='mso-margin-top-alt:0cm;margin-right:0cm;margin-bottom:6.0pt;margin-left:0cm'><b><span lang=FR style='font-size:12.0pt;font-family:"Verdana","sans-serif"'>National Institute of Chemistry; Hajdrihova 19, Ljubljana <o:p></o:p></span></b></h6><p class=MsoNormal style='mso-margin-top-alt:6.0pt;margin-right:0cm;margin-bottom:6.0pt;margin-left:0cm;text-align:justify'><b><span lang=EN-GB style='font-size:9.0pt;font-family:"Verdana","sans-serif";color:#993366'><o:p> </o:p></span></b></p><h2 align=center style='text-align:center'><span lang=EN-GB style='font-size:16.0pt;font-family:"Verdana","sans-serif";color:#993366;font-style:normal'>Protein misfolding and membrane interactions studied by solid state NMR spectroscopy<o:p></o:p></span></h2><p class=MsoNormal align=center style='text-align:center;line-height:150%'><span lang=FR style='font-size:12.0pt;line-height:150%;font-family:"Times New Roman","serif"'><o:p> </o:p></span></p><p class=MsoNormal align=center style='text-align:center;line-height:150%'><i><span style='font-size:9.0pt;line-height:150%;font-family:"Verdana","sans-serif"'>Santhosh Ayalur-Karunakaran, Quynh Hoa Do, Henrik Müller, Sabu Varghese, Henrike Heise<o:p></o:p></span></i></p><p class=MsoNormal align=center style='text-align:center;line-height:150%'><span style='font-family:"Verdana","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal align=center style='text-align:center;line-height:150%'><span style='font-family:"Verdana","sans-serif"'>Amyloid fibrils or proteinaceous aggregates are not easily accessible to high-resolution structure determination, as they are neither crystalline nor soluble. In the recent decade, solid-state NMR spectroscopy has developed into a powerful tool to study even larger complex biological systems<sup>1</sup>. Here, we give an overview over the large field of applications of solid-state NMR-spectroscopy in Biology. We report studies on different amyloidogenic proteins as well as the interaction between two membrane proteins. Finally, we show results obtained on a paramagnetic model protein.<o:p></o:p></span></p><p class=MsoNormal align=center style='text-align:center;line-height:150%'><span style='font-family:"Verdana","sans-serif"'>_______<o:p></o:p></span></p><p class=MsoNormal align=center style='text-align:center;line-height:150%'><span lang=EN-GB><span lang=EN-GB style='font-size:11.0pt;font-family:"Calibri","sans-serif";mso-fareast-language:EN-US'>[1]</span> Heise, H. (2008). Solid-state NMR spectroscopy of amyloid proteins. ChemBioChem 9, 179-189.</span><span lang=EN-GB style='font-size:10.0pt;line-height:150%;font-family:"Times New Roman","serif"'><o:p></o:p></span></p><p class=MsoNormal style='text-align:justify;line-height:150%'><span lang=FR style='font-family:"Verdana","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal align=center style='text-align:center;line-height:150%'><span lang=EN-US style='font-size:12.0pt;line-height:150%;font-family:"Arial","sans-serif";mso-fareast-language:SL'>Vljudno vabljeni! / Kindly invited!</span><span style='font-family:"Verdana","sans-serif"'><o:p></o:p></span></p><p class=MsoTitle style='margin:0cm;margin-bottom:.0001pt'><span style='font-size:18.0pt;font-family:"Verdana","sans-serif";color:black;font-weight:normal'>***<o:p></o:p></span></p><p class=MsoNormal align=center style='text-align:center'><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-size:10.0pt;font-family:"Arial","sans-serif";mso-fareast-language:SL'>Lep pozdrav,</span><span style='font-size:12.0pt;font-family:"Times New Roman","serif";mso-fareast-language:SL'> </span><span style='mso-fareast-language:SL'><o:p></o:p></span></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><b><span style='font-size:10.0pt;font-family:"Arial","sans-serif";color:#990033;mso-fareast-language:SL'>Brigita Pirc</span></b><span style='mso-fareast-language:SL'><o:p></o:p></span></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='mso-fareast-language:SL'><img width=56 height=32 id="Picture_x0020_3" src="cid:image001.jpg@01CC0BF3.E9236070" alt="Description: Description: LOGO EPRUVETE ki"> </span><span style='font-size:12.0pt;font-family:"Times New Roman","serif";mso-fareast-language:SL'><img width=234 height=32 id="Picture_x0020_2" src="cid:image002.jpg@01CC0BF3.E9236070" alt="Description: Description: Description: H:\Documents and Settings\brigita\My Documents\Fotke\LOGO, stavba\leto-kemije-desno.jpg"></span><span style='mso-fareast-language:SL'><o:p></o:p></span></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-size:9.0pt;font-family:"Arial","sans-serif";mso-fareast-language:SL'>Kemijski inštitut</span><span style='font-size:9.0pt;font-family:"Times New Roman","serif";mso-fareast-language:SL'> <br></span><span style='font-size:9.0pt;font-family:"Arial","sans-serif";mso-fareast-language:SL'>Hajdrihova 19</span><span style='font-size:9.0pt;mso-fareast-language:SL'><br></span><span style='font-size:9.0pt;font-family:"Arial","sans-serif";mso-fareast-language:SL'>SI-1001 Ljubljana</span><span style='font-size:9.0pt;font-family:"Times New Roman","serif";mso-fareast-language:SL'> <br></span><span style='font-size:9.0pt;font-family:"Arial","sans-serif";mso-fareast-language:SL'>Tel.: + 386 /1/ 4760 - 225</span><span style='font-size:9.0pt;font-family:"Times New Roman","serif";mso-fareast-language:SL'><br></span><span style='font-size:9.0pt;font-family:"Arial","sans-serif";mso-fareast-language:SL'>Fax: + 386 /1/ <span style='color:black'>4760 - 300</span></span><span style='font-size:9.0pt;font-family:"Times New Roman","serif";mso-fareast-language:SL'><br></span><a href="http://www.ki.si/"><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:blue;mso-fareast-language:SL'>http://www.ki.si/</span></a><span style='font-size:9.0pt;font-family:"Arial","sans-serif";mso-fareast-language:SL'> </span><span style='font-size:9.0pt;font-family:"Times New Roman","serif";mso-fareast-language:SL'><o:p></o:p></span></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify'><span style='font-size:7.5pt;font-family:"Arial","sans-serif";mso-fareast-language:SL'>Kemijski inštitut je javni raziskovalni zavod, ki opravlja javno službo na področju znanstvene in raziskovalno-razvojne dejavnosti. Katalog informacij javnega značaja je dostopen na spletnem naslovu </span><a href="http://www.ki.si/o-institutu/katalog-ijz"><span style='font-size:7.5pt;font-family:"Arial","sans-serif";color:blue;mso-fareast-language:SL'>www.ki.si/o-institutu/katalog-ijz</span></a><span style='font-size:7.5pt;font-family:"Arial","sans-serif";mso-fareast-language:SL'>.<o:p></o:p></span></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;text-align:justify'><span style='font-size:7.5pt;font-family:"Arial","sans-serif";mso-fareast-language:SL'>To sporočilo in vsi pripeti dokumenti so zaupni in namenjeni izključno naslovniku. Če vam sporočilo ni bilo namenjeno, ni dovoljeno razkrivanje, nadaljnje pošiljanje ali drugačna uporaba oziroma predelava posredovanih informacij. V tem primeru vas prosimo, da obvestite pošiljatelja in sporočilo izbrišete. Kemijski inštitut ne prevzema odgovornosti za napake v prenosu.</span><span style='mso-fareast-language:SL'><o:p></o:p></span></p><p class=MsoNormal style='mso-margin-top-alt:auto;mso-margin-bottom-alt:auto'><span style='font-size:32.0pt;font-family:Webdings;color:green;mso-fareast-language:SL'>P</span><span style='font-size:10.0pt;font-family:"Verdana","sans-serif";color:green;mso-fareast-language:SL'> </span><span style='font-size:8.0pt;font-family:"Arial","sans-serif";color:green;mso-fareast-language:SL'>Morate res natisniti to sporočilo? Mislite zeleno.</span><span style='font-size:9.0pt;font-family:"Arial","sans-serif";color:green;mso-fareast-language:SL'><o:p></o:p></span></p><p class=MsoNormal><span style='font-size:10.0pt;font-family:"Courier New";mso-fareast-language:SL'><o:p> </o:p></span></p><p class=MsoNormal><o:p> </o:p></p></div></body></html>