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</o:shapelayout></xml><![endif]--></head><body lang=SL link=blue vlink=purple><div class=WordSection1><p class=MsoNormal>Vabimo vas na 12. predavanje iz sklopa "Kolokviji na IJS" v letu 2014/15, ki bo<span style='color:red'> <b>v ponedeljek, 23. marca 2015, ob 13. uri </b>v Veliki predavalnici Instituta »Jožef Stefan«<b> </b></span>na Jamovi cesti 39 v Ljubljani. Napovednik predavanja najdete tudi na naslovu <a href="http://www.ijs.si/ijsw/Koledar_prireditev">http://www.ijs.si/ijsw/Koledar_prireditev</a>, posnetke preteklih predavanj<span style='color:blue'> </span>pa na <a href="http://videolectures.net/kolokviji_ijs">http://videolectures.net/kolokviji_ijs</a>. <o:p></o:p></p><p class=MsoNormal style='margin-bottom:12.0pt'>~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~<span style='color:#1F497D'><o:p></o:p></span></p><p class=MsoNormal><b><span style='font-size:14.0pt'>akad. prof. dr. Vito Turk<o:p></o:p></span></b></p><p class=MsoNormal><i>Institut “Jožef Stefan” in Mednarodna podiplomska šola Jožefa Stefana<o:p></o:p></i></p><p class=MsoNormal align=center style='text-align:center'><b><span style='font-size:14.0pt'><o:p> </o:p></span></b></p><p class=MsoNormal align=center style='mso-margin-top-alt:auto;margin-bottom:12.0pt;text-align:center'><b><span style='font-size:14.0pt'>Lizosomalni katepsini in njihovi endogeni inhibitorji − 50 let raziskav<span style='color:#1F497D'><o:p></o:p></span></span></b></p><p class=MsoNormal align=center style='mso-margin-top-alt:auto;margin-bottom:12.0pt;text-align:center'><b><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></b></p><p class=MsoNormal style='text-align:justify'>Odkritje celične organele lizosoma leta 1955 kot glavne komponente endozomalno-lizosomalnega sistema predstavlja prelomnico v razumevanju procesov intracelularne razgradnje proteinov. V zelo kratkem času je bil lizosomalni koncept sprejet, kar je bilo ključnega pomena za razumevanje osnov procesov proteinske razgradnje v normalnih in patoloških procesih. Pri tem igrajo lizosomalni katepsini izjemno pomembno vlogo in so zato postali atraktivna tarča mnogih raziskovalcev v svetu. Naša raziskovalna skupina se je vključila v te raziskave že v zgodnjih šestdesetih letih, kar je vodilo do odkritja nekaterih katepsinov, njihove karakterizacije, določitev struktur in mehanizmov delovanja. Med prvimi smo tudi odkrili njihove endogene proteinske inhibitorje cistatine in stefine, določili njihove strukture ter mehanizme interakcije s katepsini. Nadaljnje raziskave so vodile v razumevanje vloge vseh teh preiskovanih proteinov v nekaterih obolenjih kot so rak in vnetni procesi. Nedavno je bilo ugotovljeno, da so tudi katepsini pomembne signalne molekule. Sedanji izziv pa predstavlja identifikacija substratov katepsinov, kar bi omogočilo boljši vpogled v mehanizme razgradnje in procesiranje substratov. S temi raziskavami se je skupina uvrstila med najuglednejše na tem področju na svetu, kar kažejo tako objave kot tudi njihova citiranost.<o:p></o:p></p><p class=MsoNormal style='text-align:justify'><o:p> </o:p></p><p class=MsoNormal>Predavanje bo v slovenščini.<o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt'><b><span style='font-family:"Calibri","sans-serif";color:red'>Lepo vabljeni!</span></b><o:p></o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p></div></body></html>