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</o:shapelayout></xml><![endif]--></head><body lang=SL link=blue vlink=purple><div class=WordSection1><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal>Vabimo vas na 8. predavanje iz sklopa "Kolokviji na IJS" v letu 2013/14, ki bo <strong><span style='color:red'>v četrtek, 23. januarja 2014, ob 13. uri </span></strong><span style='color:red'>v Veliki predavalnici Instituta »Jožef Stefan«</span> na Jamovi cesti 39 v Ljubljani. Napovednik predavanja najdete tudi na naslovu <a href="http://www.ijs.si/ijsw/Koledar_prireditev">http://www.ijs.si/ijsw/Koledar_prireditev</a>, posnetke preteklih predavanj<span style='color:blue'> </span>pa na <a href="http://videolectures.net/kolokviji_ijs">http://videolectures.net/kolokviji_ijs</a>. <o:p></o:p></p><p class=MsoNormal style='margin-bottom:12.0pt'>~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~<o:p></o:p></p><p class=MsoNormal><b>prof. dr. Ron M. A. Heeren<o:p></o:p></b></p><p class=MsoNormal><i>FOM-AMOLF, Science Park 104, 1098 XG Amsterdam, Nizozemska<o:p></o:p></i></p><p class=MsoNormal><b><span style='font-size:14.0pt'><o:p> </o:p></span></b></p><p class=MsoNormal style='text-align:justify'><b><span style='font-size:14.0pt'>Raziskave molekularnega profila bolezni s slikanjem molekul z masno spektrometrijo<o:p></o:p></span></b></p><p class=MsoNormal style='text-align:justify'><span style='font-size:11.0pt;font-family:"Calibri","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt;text-align:justify'>Študij procesov molekularne signalizacije v povezavi z boleznimi ne zahteva le detekcije in analize molekul, ki pri tem sodelujejo, temveč tudi ovrednotenje njihove prostorske porazdelitve. Različne ravni kompleksnosti rakavih obolenj na molekularnem nivoju lahko slikovno opazujemo z različnimi tehnikami, med njimi s slikovno masno spektrometrijo, ki se je začela na tem področju uveljavljati že pred tremi desetletji. Za vpogled v razvoj bolezni smo razvili multimodalni pristop, ki združuje tehnike slikovne masne spektrometrije z optično mikroskopijo, slikanjem z magnetno resonanco in tarčnim imunohistokemijskim slikanjem. Poleg tega smo v postopek slikanja vključili tudi najsodobnejše kvantitativne proteomske in metabolomske preiskave izbranih tkiv. Predstavili bomo uporabo novih kemijskih mikroskopov za analize bioloških tkiv, posebej tistih, ki so usmerjene v raziskave raka. Pokazali bomo, kako lahko multimodalno slikanje z masno spektrometrijo osvetli vpliv lokalnega okolja na signalizacijske poti bolezni. <o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt;text-align:justify'>Predavanje bo v angleščini.<o:p></o:p></p><p class=MsoNormal style='mso-margin-top-alt:auto;margin-bottom:12.0pt'><strong><span style='font-family:"Calibri","sans-serif";color:red'>Lepo vabljeni!</span></strong><strong><span style='font-weight:normal'><o:p></o:p></span></strong></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal align=center style='text-align:center'><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:black'>*****<o:p></o:p></span></p><p class=MsoNormal align=center style='text-align:center'><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal><span style='color:black'>We invite you </span>to the 8th Institute <span style='color:black'>colloquium in the academic year 2013/14. The colloquium will be held </span><b><span style='color:red'>on Thursday January 23, 2014 at 1 PM</span></b><span style='color:red'> in <b>the main Institute lecture hall</b></span><span style='color:black'>, Jamova 39, Ljubljana. To read the abstract click </span><span style='color:#1F497D'><a href="http://www.ijs.si/ijsw/Koledar_prireditev">http://www.ijs.si/ijsw/Koledar_prireditev</a>. </span><span style='color:black'>Past colloquia are posted on</span><span style='color:#1F497D'> <a href="http://videolectures.net/kolokviji_ijs">http://videolectures.net/kolokviji_ijs</a>.<o:p></o:p></span></p><p class=MsoNormal><span style='color:#1F497D'><o:p> </o:p></span></p><p class=MsoNormal style='margin-bottom:12.0pt'>********************************************<b><o:p></o:p></b></p><p class=MsoNormal><b>prof. dr. Ron M. A. Heeren<o:p></o:p></b></p><p class=MsoNormal><i>FOM-AMOLF, Science Park 104, 1098 XG Amsterdam, The Netherlands<o:p></o:p></i></p><p class=MsoNormal><i><o:p> </o:p></i></p><p class=MsoNormal><b><span style='font-size:16.0pt'><o:p> </o:p></span></b></p><p class=MsoNormal><b><span style='font-size:16.0pt'>The study of molecular disease profiles with mass spectrometry<o:p></o:p></span></b></p><p class=MsoNormal><b><span style='font-size:16.0pt'>based molecular imaging approaches<o:p></o:p></span></b></p><p class=MsoNormal><span style='font-size:11.0pt;font-family:"Calibri","sans-serif"'><o:p> </o:p></span></p><p class=MsoNormal>The study of molecular signaling processes related to disease requires not only the detection and analysis of the molecules involved but also the evaluation of their spatial organization. Many molecular imaging modalities have addressed the different levels of complexity of cancer, and mass spectrometry imaging was added to the multimodal toolbox three decades ago. We have developed a multimodal approach that combines a number of innovative mass spectrometric imaging approaches with optical imaging, magnetic resonance imaging and targeted immunohistochemistry images to refine our understanding of disease progression. In addition we have integrated state-of-the-art quantitative proteomics and metabolomic studies of selected tissues in our molecular imaging workflow. We will discuss applications of new chemical microscopes in biomedical tissue analysis targeting cancer research in particular, and showhow the multimodal mass spectrometry imaging can elucidate the way in which local environments can influence signaling pathways in diseases..<o:p></o:p></p></div></body></html>