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<div class=Section1>
<p class=MsoTitle><b style='mso-bidi-font-weight:normal'><font size=5
face=Arial><span lang=EN-GB style='font-size:18.0pt;line-height:150%;
mso-bidi-font-family:Arial'>Dobitnik Zoisovega priznanja<o:p></o:p></span></font></b></p>
<p class=MsoTitle><b style='mso-bidi-font-weight:normal'><font size=5
face=Arial><span lang=EN-GB style='font-size:18.0pt;line-height:150%;
mso-bidi-font-family:Arial'>za pomembne znanstvene dosežke<o:p></o:p></span></font></b></p>
<p class=MsoNormal style='line-height:150%'><b style='mso-bidi-font-weight:
normal'><font size=3 face=Arial><span lang=EN-GB style='font-size:12.0pt;
mso-bidi-font-size:10.0pt;line-height:150%;font-family:Arial;font-weight:bold;
mso-bidi-font-weight:normal'><o:p> </o:p></span></font></b></p>
<p class=MsoNormal align=center style='text-align:center;line-height:150%'><b
style='mso-bidi-font-weight:normal'><font size=6 face=Arial><span lang=EN-GB
style='font-size:24.0pt;line-height:150%;font-family:Arial;font-weight:bold;
mso-bidi-font-weight:normal'>prof. dr. Igor Križaj<o:p></o:p></span></font></b></p>
<p class=MsoNormal align=center style='text-align:center;line-height:150%'><b
style='mso-bidi-font-weight:normal'><font size=3 face=Arial><span lang=EN-GB
style='font-size:12.0pt;line-height:150%;font-family:Arial;font-weight:bold;
mso-bidi-font-weight:normal'>Odsek za biokemijo in molekularno biologijo<o:p></o:p></span></font></b></p>
<p class=MsoNormal align=center style='text-align:center;line-height:150%'><b
style='mso-bidi-font-weight:normal'><font size=4 face=Arial><span lang=EN-GB
style='font-size:14.0pt;line-height:150%;font-family:Arial;font-weight:bold;
mso-bidi-font-weight:normal'>Institut “Jožef Stefan”, </span></font></b><st1:City><st1:place><b
style='mso-bidi-font-weight:normal'><font size=4 face=Arial><span lang=EN-GB
style='font-size:14.0pt;line-height:150%;font-family:Arial;font-weight:bold;
mso-bidi-font-weight:normal'>Ljubljana</span></font></b></st1:place></st1:City><b
style='mso-bidi-font-weight:normal'><font size=5 face=Arial><span lang=EN-GB
style='font-size:16.0pt;line-height:150%;font-family:Arial;font-weight:bold;
mso-bidi-font-weight:normal'><o:p></o:p></span></font></b></p>
<p class=MsoTitle align=left style='text-align:left'><span lang=EN-GB
style='mso-bidi-font-family:Arial'><o:p> </o:p></span></p>
<p class=MsoTitle><b style='mso-bidi-font-weight:normal'><font size=5
face=Arial><span lang=EN-GB style='font-size:18.0pt;line-height:150%;
mso-bidi-font-family:Arial'>Naravni toksini, potencialna orodja v biomedicini<o:p></o:p></span></font></b></p>
<p class=MsoNormal align=center style='text-align:center;line-height:150%'><b
style='mso-bidi-font-weight:normal'><i style='mso-bidi-font-style:normal'><font
size=3 face=Arial><span style='font-size:12.0pt;mso-bidi-font-size:10.0pt;
line-height:150%;font-family:Arial;mso-ansi-language:SL;mso-fareast-language:
EN-US;layout-grid-mode:line;font-weight:bold;mso-bidi-font-weight:normal;
font-style:italic;mso-bidi-font-style:normal'>Kako delujejo presinaptično nevrotoksične
fosfolipaze A<sub>2</sub>?</span></font></i></b><b style='mso-bidi-font-weight:
normal'><font size=3 face=Arial><span lang=EN-GB style='font-size:12.0pt;
mso-bidi-font-size:10.0pt;line-height:150%;font-family:Arial;font-weight:bold;
mso-bidi-font-weight:normal'><o:p></o:p></span></font></b></p>
<p class=MsoNormal align=center style='text-align:center;line-height:150%'><font
size=3 face=Arial><span lang=EN-GB style='font-size:12.0pt;mso-bidi-font-size:
10.0pt;line-height:150%;font-family:Arial'><o:p> </o:p></span></font></p>
<p class=MsoNormal align=center style='text-align:center;line-height:150%'><font
size=3 face=Arial><span lang=EN-GB style='font-size:12.0pt;mso-bidi-font-size:
10.0pt;line-height:150%;font-family:Arial'><o:p> </o:p></span></font></p>
<p class=MsoNormal style='text-align:justify;line-height:150%;tab-stops:21.3pt'><font
size=1 face=Arial><span lang=EN-GB style='font-size:9.0pt;line-height:150%;
font-family:Arial'>Strupene živali, rastline in mikroorganizmi so bogat vir
najrazličnejših farmakološko aktivnih snovi. Na predavanju bo tekla beseda o
raziskavah molekularnega mehanizma delovanja presinaptično nevrotoksičnih
fosfolipaz A<sub>2</sub>, t.i. ß-nevrotoksinov, ki preprečijo komunikacijo
živca s sosednjimi celicami. Delovanje ß-nevrotoksinov je kompleksen proces, ki
ga sproži vezava toksina na receptor v aksolemi. S pomočjo modelnega
ß-nevrotoksina, amoditoksina iz strupa modrasa, je bilo odkritih in opisanih še
več specifičnih nevronskih vezavnih proteinov. Predstavljena bo hipoteza
delovanja amoditoksina na živčno celico. Natančno razumevanje mehanizma
delovanja je predpogoj za uporabo ß-nevrotoksinov kot orodij pri raziskavah
procesov na molekularni ravni, ki potekajo v živčnih končičih, kot tudi v
medicini, pri zdravljenju nekaterih živčnih obolenj.<o:p></o:p></span></font></p>
<p class=MsoNormal align=center style='text-align:center;line-height:150%;
tab-stops:21.3pt'><font size=3 face=Arial><span lang=EN-GB style='font-size:
12.0pt;mso-bidi-font-size:10.0pt;line-height:150%;font-family:Arial'><o:p> </o:p></span></font></p>
<p class=MsoNormal align=center style='text-align:center;line-height:150%;
tab-stops:21.3pt'><b style='mso-bidi-font-weight:normal'><font size=4
face=Arial><span lang=EN-GB style='font-size:14.0pt;line-height:150%;
font-family:Arial;font-weight:bold;mso-bidi-font-weight:normal'>Vabljeni!<o:p></o:p></span></font></b></p>
<p class=MsoNormal align=center style='text-align:center;line-height:150%;
tab-stops:21.3pt'><b style='mso-bidi-font-weight:normal'><font size=6
face=Arial><span lang=EN-GB style='font-size:22.0pt;line-height:150%;
font-family:Arial;font-weight:bold;mso-bidi-font-weight:normal'>v sredo, 16.
februarja 2005, ob 13.00 uri<o:p></o:p></span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><b style='mso-bidi-font-weight:
normal'><font size=3 face=Arial><span lang=EN-GB style='font-size:12.0pt;
font-family:Arial;font-weight:bold;mso-bidi-font-weight:normal'>V VELIKI
PREDAVALNICI INSTITUTA “JOŽEF STEFAN”<o:p></o:p></span></font></b></p>
<p class=MsoNormal align=center style='text-align:center'><b style='mso-bidi-font-weight:
normal'><font size=3 face=Arial><span lang=EN-GB style='font-size:12.0pt;
font-family:Arial;font-weight:bold;mso-bidi-font-weight:normal'>Institut
“Jožef Stefan”, Jamova 39, 1000 </span></font></b><st1:City><st1:place><b
style='mso-bidi-font-weight:normal'><font size=3 face=Arial><span lang=EN-GB
style='font-size:12.0pt;font-family:Arial;font-weight:bold;mso-bidi-font-weight:
normal'>Ljubljana</span></font></b></st1:place></st1:City><b
style='mso-bidi-font-weight:normal'><font size=3 face=Arial><span lang=EN-GB
style='font-size:12.0pt;font-family:Arial;font-weight:bold;mso-bidi-font-weight:
normal'>, <a href="http://www.ijs.si/">http://www.ijs.si</a><o:p></o:p></span></font></b></p>
<p class=MsoNormal><font size=2 face=Arial><span lang=EN-GB style='font-size:
10.0pt;font-family:Arial'><o:p> </o:p></span></font></p>
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